Radioprotective effects of a nitric oxide scavenger, Fe (DETC)<sub>2</sub>, on mice

Yuanyuan LI; Yurui ZHANG; Wenqing XU

doi:10.11889/j.1000-3436.2017.rrj.35.040203

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Radioprotective effects of a nitric oxide scavenger, Fe (DETC)₂, on mice

RADIBIOLOGY AND RADIOMEDICINE | 更新时间：2021-12-10

- Radioprotective effects of a nitric oxide scavenger, Fe (DETC)₂, on mice
- Journal of Radiation Research and Radiation Processing Vol. 35, Issue 4, (2017)
- 作者机构：
  
  1.中国医学科学院北京协和医学院放射医学研究所天津 300192
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China(81273005);Tianjin Municipal Science and Technology Commission(14JCZDJC36400)
- DOI：10.11889/j.1000-3436.2017.rrj.35.040203
  CLC：
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Yuanyuan LI, Yurui ZHANG, Wenqing XU. Radioprotective effects of a nitric oxide scavenger, Fe (DETC)₂, on mice. [J]. Journal of Radiation Research and Radiation Processing 35(4):040203-5(2017)
DOI：

Yuanyuan LI, Yurui ZHANG, Wenqing XU. Radioprotective effects of a nitric oxide scavenger, Fe (DETC)₂, on mice. [J]. Journal of Radiation Research and Radiation Processing 35(4):040203-5(2017) DOI： 10.11889/j.1000-3436.2017.rrj.35.040203.

摘要

采用小鼠30 d存活率实验和外周血白细胞、骨髓DNA含量、脾克隆形成单位及各脏器指数指标考察NO特异性清除剂二乙基二硫代氨基甲酸亚铁（Fe（DETC）,2,）对辐射损伤小鼠的保护作用。结果显示，与单纯照射组相比，给予不同剂量Fe（DETC）,2,后，照射给药组小鼠30 d存活率、外周血白细胞数、骨髓DNA含量、脾克隆形成单位及各脏器指数均有不同程度的提高，特别是二乙基二硫代氨基甲酸钠（DETC）以300 mg/kg的剂量腹腔注射，可使存活率提高约43%，白细胞数、骨髓DNA含量和脾克隆形成单位与单纯照射组相比具有统计学意义（,p,<, 0.01）。结果提示，一氧化氮清除剂Fe（DETC）,2,对辐射损伤小鼠具有一定的保护作用。

Abstract

A 30-day survival rate experiment was carried out, and the assays of peripheral blood leukocytes, bone marrow DNA content, colony forming units of the spleen (CFU-S), and organ index parameters were analyzed to evaluate the protective effect of a nitric oxide-specific scavenger, Fe,2+,-diethyldithiocarbamate complex (Fe(DETC),2,), on radiation-injured mice. The results showed that compared with the irradiation group, the 30 d survival rate, peripheral blood leukocytes, bone marrow DNA content, CFU-S, and organ index were significantly different from those in the mice treated with different doses. In particular, DETC was administered intraperitoneally at a dose of 300 mg/kg, which increased the survival rate by about 43%, and changes in the number of white blood cells, bone marrow DNA content, and CFU-S were statistically significant (,p,<, 0.01). It is suggested that Fe(DETC),2, a nitric oxide scavenger, has a protective effect on radiation-injured mice.

关键词

NO清除剂Fe（DETC）2辐射防护

Keywords

Nitric oxide scavengerFe(DETC)2Radiation protection

references

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Radioprotective effects of a nitric oxide scavenger, Fe (DETC)2, on mice

DOI：10.11889/j.1000-3436.2017.rrj.35.040203

摘要

Abstract

关键词

Keywords

references

Radioprotective effects of a nitric oxide scavenger, Fe (DETC)₂, on mice