Research progress in autophagy in nasopharyngeal carcinoma radiotherapy

Xiyu YANG; Guoqi ZHAO

doi:10.11889/j.1000-3436.2017.rrj.35.050101

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Research progress in autophagy in nasopharyngeal carcinoma radiotherapy

REVIEW | 更新时间：2021-12-10

- Research progress in autophagy in nasopharyngeal carcinoma radiotherapy
- Journal of Radiation Research and Radiation Processing Vol. 35, Issue 5, (2017)
- 作者机构：
  
  1.重庆医科大学临床学院重庆 400016
  2.上海交通大学附属第一人民医院肿瘤中心上海 201620
- 作者简介：
- 基金信息：
- DOI：10.11889/j.1000-3436.2017.rrj.35.050101
  CLC：
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Xiyu YANG, Guoqi ZHAO. Research progress in autophagy in nasopharyngeal carcinoma radiotherapy. [J]. Journal of Radiation Research and Radiation Processing 35(5):050101-8(2017)
DOI：

Xiyu YANG, Guoqi ZHAO. Research progress in autophagy in nasopharyngeal carcinoma radiotherapy. [J]. Journal of Radiation Research and Radiation Processing 35(5):050101-8(2017) DOI： 10.11889/j.1000-3436.2017.rrj.35.050101.

摘要

自噬对鼻咽癌（Nasopharyngeal carcinoma，NPC）具有抑瘤和促瘤双重作用。自噬在NPC发生、发展及转归中起重要作用：低水平、基础自噬有利于细胞的自我保护与新陈代谢，是NPC放、化疗抵抗的重要因素之一；高水平、过度自噬则可导致自噬性细胞死亡，是基于自噬靶点的NPC治疗基础。自噬剂的研发与应用是实现自噬水平调控的关键环节，自噬抑制剂或自噬诱导剂可增敏NPC放、化疗甚至诱导其自噬性细胞死亡，但其作用机理颇为复杂且迄今尚未完全明了。本文着重综述自噬与NPC放疗研究进展，并探讨自噬作为新靶点的NPC治疗前景，尤其X射线作为自噬剂以诱导NPC发生治疗性的自噬性细胞死亡。

Abstract

Cell autophagy could not only inhibit but also promote tumor growth, which plays an important role in the occurrence, development, and clinical prognosis of nasopharyngeal carcinoma (NPC). The low-level and basic autophagy is conducive to its cell metabolism and self-protection, which is one of the major factors in NPC radio-or chemo-therapy resistance, while high-level and excessive autophagy could lead to the autophagic cell death, which is the foundation of NPC treatment based on autophagic target. The research and application of autophagy modulators is the key link to realize the regulation of autophagy level. Autophagy inhibitors or inducers can enhance sensitization to radio-or chemo-therapy and even induce autophagic death of NPC cells. The mechanism of action of autophagy in NPC is, however, very complex and not yet fully understood up to now. Here, we reviewed the research progress in autophagy and its potential value in NPC radiotherapy in order to explore the prospect of autophagy as a new target for NPC treatment, especially therapeutic autophagic cell death in NPC induced by X-ray as an autophagy modulator.

关键词

鼻咽癌自噬放射治疗自噬剂

Keywords

Nasopharyngeal carcinomaAutophagyRadiotherapyAutophagy modulators

references

F Petersson . Nasopharyngeal carcinoma:A review . Seminars in Diagnostic Pathology , 2015 . 32 (1 ):54 -73 . DOI:10.1053/j.semdp.2015.02.021http://doi.org/10.1053/j.semdp.2015.02.021 .

安乐乐 , 马琳艳 , 陈根德 , 等 . 自噬抑制剂3-甲基腺嘌呤增强鼻咽癌细胞对放射和化学治疗的敏感性 . 中南大学学报(医学版) , 2016 . 41 (1 ):9 -18 . DOI:10.11817/j.issn.1672-7347.2016.01.002http://doi.org/10.11817/j.issn.1672-7347.2016.01.002 .

Lele AN , Linyan MA , Gende CHEN , 等 . Autophagy inhibitor 3-methyladenine enhances the sensitivity of nasopharyngeal carcinoma cells to chemotherapy and radiotherapy . Journal of Central South University (Medical Sciences) , 2016 . 41 (1 ):9 -18 . DOI:10.11817/j.issn.1672-7347.2016.01.002http://doi.org/10.11817/j.issn.1672-7347.2016.01.002 .

D C Lin , X Meng , M Hazawa , 等 . The genomic landscape of nasopharyngeal carcinoma . Nature Genetics , 2014 . 46 (8 ):866 -871 . DOI:10.1038/ng.3006http://doi.org/10.1038/ng.3006 .

曹新格 , 王雅棣 , 张勇乾 , 等 . 鼻咽癌螺旋断层治疗的剂量学研究 . 中华放射肿瘤学杂志 , 2016 . 25 (8 ):802 -806 . DOI:10.3760/cma.j.issn.1004-4221.2016.08.0035http://doi.org/10.3760/cma.j.issn.1004-4221.2016.08.0035 .

Xinge CAO , Yadi WANG , Yongqian ZHANG , 等 . A dosimetric study of helical tomotherapy for nasopharyn-geal carcinoma . Chinese Journal of Radiation Oncology , 2016 . 25 (8 ):802 -806 . DOI:10.3760/cma.j.issn.1004-4221.2016.08.0035http://doi.org/10.3760/cma.j.issn.1004-4221.2016.08.0035 .

W Gao , J W Lam , J Z Li , 等 . MicroRNA-138-5p controls sensitivity of nasopharyngeal carcinoma to radiation by targeting EIF4EBP1 . Oncology Reports , 2017 . 37 (2 ):913 -920 . DOI:10.3892/or.2017.5354http://doi.org/10.3892/or.2017.5354 .

牛超 , 金利泰 . 细胞自噬作用及其在相关疾病中的重要生理意义-2016年诺贝尔生理学或医学奖解读 . 中国医药生物技术 , 2017 . 12 (1 ):45 -48. .

Chao NIU , Litai JIN . Cell autophagy and its important physiological significance in related diseases-Notes of 2016 Nobel Prize in Physiology or Medicine . Chinese Medicinal Biotechnology , 2017 . 12 (1 ):45 -48 . DOI:10.3969/j.issn.1673-713X.2017.01.009http://doi.org/10.3969/j.issn.1673-713X.2017.01.009 .

郭晓明 , 陈琦 . 自噬在肿瘤细胞中的功能与应用前景 . 实用癌症杂志 , 2017 . 32 (10 ):171 -172 . DOI:10.3969/j.issn.1001-5930.2017.01.055http://doi.org/10.3969/j.issn.1001-5930.2017.01.055 .

Xiaoming GUO , Qi CHEN . The function and application prospect of autophagy in tumor cells . The Practical Journal of Cancer , 2017 . 32 (10 ):171 -172 . DOI:10.3969/j.issn.1001-5930.2017.01.055http://doi.org/10.3969/j.issn.1001-5930.2017.01.055 .

方彪彪 , 张淑君 , 成秉林 . 自噬与一些肿瘤影响因素之间的关系 . 现代肿瘤医学 , 2017 . 25 (1 ):158 -160 . DOI:10.3969/j.issn.1672-4992.2017.01.043http://doi.org/10.3969/j.issn.1672-4992.2017.01.043 .

Biaobiao FANG , Shujun ZHANG , Binglin CHENG . The interactions of autophagy and some tumor influencing factors . Modern Oncology , 2017 . 25 (1 ):158 -160 . DOI:10.3969/j.issn.1672-4992.2017.01.043http://doi.org/10.3969/j.issn.1672-4992.2017.01.043 .

L L Hu , K Jiang , C Ding , 等 . Targeting autophagy for oncolytic immunotherapy . Biomedicines , 2017 . 5 (1 ):DOI:10.3390/biomedicines5010005http://doi.org/10.3390/biomedicines5010005 .

王佳 , 周文胜 . 细胞自噬及其在鼻咽癌中的作用 . 临床与病理杂志 , 2015 . 35 (10 ):1837 -1841 . DOI:10.3978/j.issn.2095-6959.2015.10.026http://doi.org/10.3978/j.issn.2095-6959.2015.10.026 .

Jia WANG , Wensheng ZHOU . Autophagy and its role in nasopharyngeal carcinoma . International Journal of Pathology and Clinical Medicine , 2015 . 35 (10 ):1837 -1841 . DOI:10.3978/j.issn.2095-6959.2015.10.026http://doi.org/10.3978/j.issn.2095-6959.2015.10.026 .

A Thorburn , D H Thamm , D L Gustafson . Autophagy and Cancer Therapy . Molecular Pharmacology , 2014 . 85 830 -838 . DOI:10.1124/mol.114.091850http://doi.org/10.1124/mol.114.091850 .

李乐兴 , 戴汉川 . 细胞自噬调控的分子机制研究进展 . 中国细胞生物学学报 , 2015 . 37 (2 ):263 -270 . DOI:10.11844/cjcb.2015.02.0271http://doi.org/10.11844/cjcb.2015.02.0271 .

Lexing LI , Hanchuan DAI . Research progress of the molecular mechanism of autophagy regulation . Chinese Journal of Cell Biology , 2015 . 37 (2 ):263 -270 . DOI:10.11844/cjcb.2015.02.0271http://doi.org/10.11844/cjcb.2015.02.0271 .

曾荣华 , 崔德威 . 自噬与肿瘤放射治疗的关系及研究进展 . 中国医学创新 , 2013 . 10 (33 ):157 -159 . DOI:10.3969/j.issn.1674-4985.2013.33.074http://doi.org/10.3969/j.issn.1674-4985.2013.33.074 .

Ronghua ZENG , Dewei CUI . Research progress on relationship of autophagy and tumor radiation therapy . Medical Innovation of China , 2013 . 10 (33 ):157 -159 . DOI:10.3969/j.issn.1674-4985.2013.33.074http://doi.org/10.3969/j.issn.1674-4985.2013.33.074 .

R K Amaravadi , C B Thompson . The roles of therapy-induced autophagy and necrosis in cancer treatment . Clinical Cancer Research , 2007 . 13 (24 ):7271 -7279 . DOI:10.1158/1078-0432.CCR-07-1595http://doi.org/10.1158/1078-0432.CCR-07-1595 .

曾谷清 , 黄丽芳 , 廖力 . 鼻咽癌放疗抵抗的分子机制研究进展 . 中国现代医学杂志 , 2016 . 26 (3 ):82 -86 . DOI:10.3969/j.issn.1005-8982.2016.03.017http://doi.org/10.3969/j.issn.1005-8982.2016.03.017 .

Guqing ZENG , Lifang HUANG , Li LIAO . Research progress on molecular mechanism of nasopharyngeal carcinoma radioresistance . China Journal of Modern Medicine , 2016 . 26 (3 ):82 -86 . DOI:10.3969/j.issn.1005-8982.2016.03.017http://doi.org/10.3969/j.issn.1005-8982.2016.03.017 .

R Kim , M Emi , K Tanabe , 等 . The role of apoptotic or nonapoptotic cell death in determining cellular response to anticancer treatment . European Journal of Surgical Oncology , 2006 . 32 (3 ):269 -277 . DOI:10.1016/j.ejso.2005.12.006http://doi.org/10.1016/j.ejso.2005.12.006 .

S Richard , R S Hotchkiss , A Strasser , 等 . Cell Death . the New England Journal of Medicine , 2009 . 361 (16 ):1570 -1583 . DOI:10.1056/NEJMra0901217http://doi.org/10.1056/NEJMra0901217 .

董语迪 , 李志杰 . 程序性坏死在神经母细胞瘤中的研究进展 . 中国小儿血液与肿瘤杂志 , 2017 . 22 (1 ):46 -50 . DOI:10.3969/j.issn.1673-5323.2017.01.010http://doi.org/10.3969/j.issn.1673-5323.2017.01.010 .

Yudi DONG , Zhijie LI . Research progress of programmed necrosis in neuroblastoma . Journal of China Pediatric Blood and Cancer , 2017 . 22 (1 ):46 -50 . DOI:10.3969/j.issn.1673-5323.2017.01.010http://doi.org/10.3969/j.issn.1673-5323.2017.01.010 .

王月霞 , 陈敏 . 自噬性细胞死亡及其与细胞凋亡、坏死关系研究进展 . 中国公共卫生 , 2016 . 32 (10 ):1433 -1436 . DOI:10.11847/zgggws2016-32-10-3620http://doi.org/10.11847/zgggws2016-32-10-3620 .

Yuexia WANG , Min CHEN . Progress in researches on autophagic cell death and its relationship with apoptosis and necrosis . Chinese Journal of Public Health , 2016 . 32 (10 ):1433 -1436 . DOI:10.11847/zgggws2016-32-10-3620http://doi.org/10.11847/zgggws2016-32-10-3620 .

傅青云 , 尹善德 , 王蔼明 . 细胞自噬在妇科恶性肿瘤中的研究进展 . 转化医学杂志 , 2017 . 6 (1 ):51 -54 . DOI:10.3969/j.issn.2095-3097.2017.01.014http://doi.org/10.3969/j.issn.2095-3097.2017.01.014 .

Qingyun FU , Shande YIN , Geming WANG . A review of autophagy and gynecologic cancers . Translational Medicine Journal , 2017 . 6 (1 ):51 -54 . DOI:10.3969/j.issn.2095-3097.2017.01.014http://doi.org/10.3969/j.issn.2095-3097.2017.01.014 .

王雪 , 张评浒 . Ras/Raf/MEK/ERK信号通路参与自噬调控作用的研究进展 . 中国药科大学学报 , 2017 . 48 (1 ):110 -116 . DOI:10.11665/j.issn.1000-5048.20170117http://doi.org/10.11665/j.issn.1000-5048.20170117 .

Xue WANG , Pingxu ZHANG . Advances in research on the modulation of autophagy by Ras/Raf/MEK/ERK signaling pathway . Journal of China Pharmaceutical University , 2017 . 48 (1 ):110 -116 . DOI:10.11665/j.issn.1000-5048.20170117http://doi.org/10.11665/j.issn.1000-5048.20170117 .

T Proikas-Cezanne , H Robenek . Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes . Journal of Cellular and Molecular Medicine , 2011 . 15 (9 ):2007 -2010 . DOI:10.1111/j.1582-4934.2011.01339.xhttp://doi.org/10.1111/j.1582-4934.2011.01339.x .

I G Ganley , du H Lam , J Wang , 等 . ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essentialfor autophagy . The Journal of Biological Chemistry , 2009 . 284 (18 ):12297 -12305 . DOI:10.1074/jbc.M900573200http://doi.org/10.1074/jbc.M900573200 .

J C Chen , M J Hsieh , C J Chen , 等 . Polyphyllin G induce apoptosis and autophagy in human nasopharyngeal cancer cells by modulation of AKT and mitogen-activated protein kinase pathways in vitro and in vivo . Oncotarget , 2016 . 7 (43 ):70276 -70289 . DOI:10.18632/oncotarget.11839http://doi.org/10.18632/oncotarget.11839 .

伏园园 , 吴一诺 , 喻秀 , 等 . 自噬相关蛋白ATG4B抑制剂的虚拟筛选及体外活性测定 . 中国药理学通报 , 2017 . 33 (3 ):321 -326 . DOI:10.3969/j.issn.1001-1978.2017.03.007http://doi.org/10.3969/j.issn.1001-1978.2017.03.007 .

Yuanyuan FU , Yinuo WU , Xiu YU , 等 . Virtual screening and in vitro activity studies of novel ATG4B inhibitors . Chinese Pharmacological Bulletin , 2017 . 33 (3 ):321 -326 . DOI:10.3969/j.issn.1001-1978.2017.03.007http://doi.org/10.3969/j.issn.1001-1978.2017.03.007 .

邹燕梅 , 熊华 , 于世英 , 等 . 乏氧诱导的自噬与肺腺癌放射抵抗的相关性研究 . 华中科技大学学报(医学版) , 2011 . 40 (4 ):413 -416 . DOI:10.3870/j.issn.1672-0741.2011.04.00http://doi.org/10.3870/j.issn.1672-0741.2011.04.00 .

Yanmei ZOU , Hua XIONG , Shiying YU , 等 . Correlation between hypoxia-induced autophagy and radioresistance of lung adenocarcinoma cell line A549 . Acta Medicinae Universitatis Scientiae et Technologiae Huazhong , 2011 . 40 (4 ):413 -416 . DOI:10.3870/j.issn.1672-0741.2011.04.00http://doi.org/10.3870/j.issn.1672-0741.2011.04.00 .

E N Wilson , M L Bristol , X Di , 等 . A switch between cytoproteetive and cytotoxie autophagy in the radiosensitization of breast tumor cells by ehloroquine and vitamin D . Horm Cancer , 2011 . 2 (5 ):272 -285 . DOI:10.1007/s12672-011-0081-7http://doi.org/10.1007/s12672-011-0081-7 .

杨轩 , 袁栋栋 , 姜学军 , 等 . 顺铂通过诱导膀胱癌细胞自噬促进细胞凋亡 . 北京大学学报-医学版 , 2013 . 45 (2 ):221 -226 . DOI:10.3969/j.issn.1671-167X.2013.02.012http://doi.org/10.3969/j.issn.1671-167X.2013.02.012 .

Xuan YANG , Dongdong YUAN , Xuejun Jiang , 等 . Cisplatin enhances apoptosis in bladder cancer cells via autophagy . Journal of Peking University (Health Sciences) , 2013 . 45 (2 ):221 -226 . DOI:10.3969/j.issn.1671-167X.2013.02.012http://doi.org/10.3969/j.issn.1671-167X.2013.02.012 .

宋扬 , 刘佩娟 , 辛智倩 , 等 . GANT61通过自噬性细胞死亡抑制人乳腺癌MCF-7细胞增殖 . 肿瘤防治研究 , 2017 . 44 (1 ):1 -4 . DOI:10.3971/j.issn.1000-8578.2017.01.001http://doi.org/10.3971/j.issn.1000-8578.2017.01.001 .

Yang SONG , Peijuan LIU , Zhiqian XIN , 等 . Autophagic cell death induced by GANT61 inhibits proliferation of human breast cancer cell line MCF-7 . Cancer Research on Prevention and Treatment , 2017 . 44 (1 ):1 -4 . DOI:10.3971/j.issn.1000-8578.2017.01.001http://doi.org/10.3971/j.issn.1000-8578.2017.01.001 .

李峰 , 崔德威 , 许卫华 , 等 . X射线对人鼻咽癌CNE2及CNE2/DDP细胞自噬相关基因的影响 . 临床耳鼻咽喉头颈外科杂志 , 2015 . 29 (6 ):547 -551 . DOI:10.13201/j.issn.1001-1781.2015.06.018http://doi.org/10.13201/j.issn.1001-1781.2015.06.018 .

Feng LI , Dewei CUI , Weihua XU , 等 . The influence of autophagy-related genes about X-Ray on nasopharyngeal carcinoma CNE2 and CNE2/DDP cells . Journal of Clinical Otorhinolarynglolgy Head and Neck Surgery , 2015 . 29 (6 ):547 -551 . DOI:10.13201/j.issn.1001-1781.2015.06.018http://doi.org/10.13201/j.issn.1001-1781.2015.06.018 .

Z T Chen , W Zhao , S Qu , 等 . PARP-1 promotes autophagy via the AMPK/mTOR pathway in CNE-2 human nasopharyngeal carcinoma cells following, ionizing radiation, while inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells . Molecular Medicine Reports , 2015 . 12 (2 ):1868 -1876 . DOI:10.3892/mmr.2015.3604http://doi.org/10.3892/mmr.2015.3604 .

李宝秀 , 方喜生 , 张敏 , 等 . 自噬对鼻咽癌细胞CNE2放疗敏感性的调节作用 . 广州医药 , 2016 . 47 (3 ):4 -7 . DOI:10.3969/j.issn.1000-8535.2016.03.002http://doi.org/10.3969/j.issn.1000-8535.2016.03.002 .

Baoxiu LI , Xisheng FANG , Min ZHANG , 等 . The regulatory effects of autophagy to the CNE2 cells radio-sensitization . Guangzhou Medical Journal , 2016 . 47 (3 ):4 -7 . DOI:10.3969/j.issn.1000-8535.2016.03.002http://doi.org/10.3969/j.issn.1000-8535.2016.03.002 .

周支瑞 , 朱小东 , 赵伟 , 等 . 自噬抑制剂磷酸氯喹增加鼻咽癌CNE-2细胞株的放射敏感性 . 中华放射医学与防护杂志 , 2012 . 32 (5 ):449 -454 . DOI:10.3760/cma.j.issn.0254-5098.2012.05.001http://doi.org/10.3760/cma.j.issn.0254-5098.2012.05.001 .

Zhirui ZHOU , Xiaodong ZHU , Wei ZHAO , 等 . Contribution' of autophagy inhibitor to radiation sensitization in nasopharyngeal carcinoma cells . Chinese Journal of Radiological Medicine and Protection , 2012 . 32 (5 ):449 -454 . DOI:10.3760/cma.j.issn.0254-5098.2012.05.001http://doi.org/10.3760/cma.j.issn.0254-5098.2012.05.001 .

陈冬莲 , 候新华 , 郑华 , 等 . 大黄素对鼻咽癌CNE-1细胞放射增敏作用与细胞自噬关系的研究 . 中国药理学通报 , 2012 . 28 (11 ):1535 -1538 . DOI:10.3969/j.issn.1001-1978.2012.11.013http://doi.org/10.3969/j.issn.1001-1978.2012.11.013 .

Donglian CHEN , Xinhua HOU , Hua ZHENG , 等 . Study of the relationship between the radiotherapy sensitization function of emodin and autophagy in the nasopharyngeal carcinoma CNE-1 cells . Chinese Pharmacological Bulletin , 2012 . 28 (11 ):1535 -1538 . DOI:10.3969/j.issn.1001-1978.2012.11.013http://doi.org/10.3969/j.issn.1001-1978.2012.11.013 .

刘洋 , 刘硕 , 孙建军 . ApoG2联合放疗对鼻咽癌CNE-2细胞自噬与凋亡的影响研究 . 疑难病杂志 , 2015 . 14 (4 ):384 -386 . DOI:10.3969/j.issn.1671-6450.2015.04.016http://doi.org/10.3969/j.issn.1671-6450.2015.04.016 .

Yang LIU , Shuo LIU , Jianjun SUN . The study of the effect of ApoG2 combined with radiotherapy onautophagy and apoptosis of CNE 2 cells of nasopha-ryngeal carcinoma . Chinese Journal of Difficult and Complicated Cases , 2015 . 14 (4 ):384 -386 . DOI:10.3969/j.issn.1671-6450.2015.04.016http://doi.org/10.3969/j.issn.1671-6450.2015.04.016 .

陈向军 , 刘国磊 , 郜元坤 , 等 . 顺铂诱导鼻咽癌CNE-2细胞自噬和凋亡的体外研究 . 现代肿瘤医学 , 2015 . 23 (2 ):180 -185 . DOI:10.3969/j.issn.1672-4992.2015.02.10http://doi.org/10.3969/j.issn.1672-4992.2015.02.10 .

Xiangjun CHEN , Guolei LIU , Yuankun GAO , 等 . In vitro study on the relationship between autophagy and apoptosis induced by cisplatin in human pharyngeal carcinoma cell line CNE-2 . Journal of Modern Oncology , 2015 . 23 (2 ):180 -185 . DOI:10.3969/j.issn.1672-4992.2015.02.10http://doi.org/10.3969/j.issn.1672-4992.2015.02.10 .

周文君 , 邓蓉 , 冯公侃 , 等 . 靶向G-四链体配体SYUIQ-5抑制Akt-FOXO3a通路诱导鼻咽癌细胞自噬性死亡 . 癌症 , 2009 . 28 (10 ):1049 -1053 . http://www.cnki.com.cn/Article/CJFDTOTAL-AIZH200910011.htmhttp://www.cnki.com.cn/Article/CJFDTOTAL-AIZH200910011.htm, .

Wenjun ZHOU , Rong DENG , Gongkan FENG , 等 . A G-quadruplex ligand SYUIQ-5 induces autophagy by inhibiting the Akt-FOXO3a pathway in nasopharyngeal cancer cells . Chinese Journal of Cancer , 2009 . 28 (10 ):1049 -1053 . http://www.cnki.com.cn/Article/CJFDTOTAL-AIZH200910011.htmhttp://www.cnki.com.cn/Article/CJFDTOTAL-AIZH200910011.htm, .

卢小迪 , 朱小东 , 赵伟 , 等 . 自噬活性的降低增加人鼻咽癌CNE-2细胞的放射敏感性 . 中华放射医学与防护杂志 , 2015 . 35 (6 ):423 -427 . DOI:10.3760/cma.j.issn.0254-5098.2015.06.005http://doi.org/10.3760/cma.j.issn.0254-5098.2015.06.005 .

Xiaodi LU , Xiaodong ZHU , Wei ZHAO , 等 . Suppression of autophagy activity enhances the radiosensitivity of human nasopharyngeal carcinoma CNE-2 cells . Chinese Journal of Radiological Medicine and Protection , 2015 . 35 (6 ):423 -427 . DOI:10.3760/cma.j.issn.0254-5098.2015.06.005http://doi.org/10.3760/cma.j.issn.0254-5098.2015.06.005 .

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Effect of air gap under bolus on superficial dose and depth of dose maximum during radiotherapy

Effect of shoulder position shift on radiotherapy for head and neck cancer

Related Author

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Related Institution

Jiangsu Shengze Hospital of Nanjing Medical University

Department of Head and Neck Surgery, Gansu Province Cancer Hospital

Department of radiotherapy, Gansu Province Cancer Hospital

Department of Function, Gansu Province Cancer Hospital

Department of Radiation Physics and Technology, Hunan Cancer Hospital

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