Ionizing radiation induces cognitive dysfunction by activating prefrontal cortex NLRP3 inflammasome in mice

NAI Aitao; WANG Zhen; LUO Dan; WANG Yixuan; WAN Wei; CAO Wenyu; HE Jie; CHEN Xi; HE Shuya; WANG Wuzhou; XU Yang; AI Xiaohong

doi:10.11889/j.1000-3436.2019.rrj.37.040301

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Ionizing radiation induces cognitive dysfunction by activating prefrontal cortex NLRP3 inflammasome in mice

RADIOBIOLOGY AND RADIOMEDICINE | 更新时间：2025-03-03

- Ionizing radiation induces cognitive dysfunction by activating prefrontal cortex NLRP3 inflammasome in mice
- “The latest research has found that ionizing radiation may activate microglia and NLRP3 inflammasome, induce the release of inflammatory factors, and cause cognitive dysfunction.”
- Journal of Radiation Research and Radiation Processing Vol. 37, Issue 4, Pages: 7-14(2019)
- 作者机构：
  
  1.南华大学附属第一医院肿瘤放疗科衡阳 421001
  2.南华大学医学院应用解剖与生殖医学研究所衡阳 421001
  3.南华大学医学院病理教研室衡阳 421001
  4.南华大学公共卫生学院放射医学教研室衡阳 421001
  5.南华大学医学院生理教研室衡阳 421001
- 作者简介：
  
  NAI Aitao(male) was born in July 1992, and graduated from University of South China in 2015. Now he is a master candidate at the Department of Radiation Oncology, the First Affiliated Hospital of University of South China. E-mail: 499108712@qq.com
  XU Yang, lecturer, E-mail: xuyang2117@163.com
  AI Xiaohong, associate professor, master’s supervisor, E-mail: 116304926@qq.com; Ph.D
- 基金信息：
  
  the Natural Science Foundation of Hunan Province of China(2018JJ3460;2018JJ4034);the Education Department Foundation of Hunan Province of China(16A187;17B230);the Start-up Funds for Ph.D.s in University of South China(2015XQD27;2015XQD28);Applied Anatomy and Reproductive Medicine Key Laboratory Construction Project in Hengyang(2017KJ182);the Research-based Learning and Innovation Experimental Project for Undergraduate Student of the University of South China(2018XJXZ390);Hunan Provincial Innovation Foundation for Postgraduate(CX2018B638)
- DOI：10.11889/j.1000-3436.2019.rrj.37.040301
  CLC： R818.74
- Received：03 January 2019，
  
  Revised：11 April 2019，
  
  Accepted：2019-04-11，
  
  Published：20 August 2019
- 稿件说明：
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乃爱桃,王贞,罗丹等.电离辐射激活前额叶皮质NLRP3炎性小体诱导小鼠认知功能障碍[J].辐射研究与辐射工艺学报,2019,37(04):7-14.

NAI Aitao,WANG Zhen,LUO Dan,et al.Ionizing radiation induces cognitive dysfunction by activating prefrontal cortex NLRP3 inflammasome in mice[J].Journal of Radiation Research and Radiation Processing,2019,37(04):7-14.
乃爱桃,王贞,罗丹等.电离辐射激活前额叶皮质NLRP3炎性小体诱导小鼠认知功能障碍[J].辐射研究与辐射工艺学报,2019,37(04):7-14. DOI： 10.11889/j.1000-3436.2019.rrj.37.040301.

NAI Aitao,WANG Zhen,LUO Dan,et al.Ionizing radiation induces cognitive dysfunction by activating prefrontal cortex NLRP3 inflammasome in mice[J].Journal of Radiation Research and Radiation Processing,2019,37(04):7-14. DOI： 10.11889/j.1000-3436.2019.rrj.37.040301.

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Ionizing radiation induces cognitive dysfunction by activating prefrontal cortex NLRP3 inflammasome in mice

DOI：10.11889/j.1000-3436.2019.rrj.37.040301