Breeding of tacrolimus high-producing strains by gamma-ray radiation and nitrosoguanidine mutagent

YAN Lingbin; ZHANG Wenzhou; ZHANG Zhulan; ZHANG Yin; QIU Guanrong; WANG Desen; LIAN Yunyang

doi:10.11889/j.1000-3436.2019.rrj.37.050401

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Breeding of tacrolimus high-producing strains by gamma-ray radiation and nitrosoguanidine mutagent

RADIATION TECHNOLOGY APPLICATION | 更新时间：2025-02-28

- Breeding of tacrolimus high-producing strains by gamma-ray radiation and nitrosoguanidine mutagent
- “In the field of biological fermentation, researchers have successfully bred a high-yield tacrolimus strain FIM-17-17 using 60Co gamma ray radiation and NTG composite mutagenesis technology, with significantly improved fermentation levels.”
- Journal of Radiation Research and Radiation Processing Vol. 37, Issue 5, Pages: 49-56(2019)
- 作者机构：
  
  1.福建省微生物研究所福建省新药(微生物)筛选重点实验室福州 350007
  2.泉州医学高等专科学校泉州 362100
- 作者简介：
  
  YAN Lingbin (female) was born in January 1987, and graduated from Fuzhou University in 2012. Now she is a probationer professor in Fujian Institute of Microbiology, majoring in microbiology breeding. E-mail: lingbinyan@126.com
  ZHANG Zhulan, professor, E-mail: jessylan9963@sina.com
  Ph.D. LIAN Yunyang, professor, E-mail: ylianfim@139.com
- 基金信息：
  
  Special Project of Public Welfare Research Institute of Fujian Province of China(2019R1005-8;2017R1009-1);Science and Technology Planning Project of Fuzhou City of China(2018-G-48);Science and Technology Planning Project of Fuqing City of China (2018(6) Fuqing City )
- DOI：10.11889/j.1000-3436.2019.rrj.37.050401
  CLC： TL99;TQ465.92
- Received：17 May 2019，
  
  Revised：02 July 2019，
  
  Accepted：2019-07-02，
  
  Published：20 October 2019
- 稿件说明：
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严凌斌,张文州,张祝兰等.伽马射线辐射结合亚硝基胍诱变选育他克莫司高产菌株[J].辐射研究与辐射工艺学报,2019,37(05):49-56.

YAN Lingbin,ZHANG Wenzhou,ZHANG Zhulan,et al.Breeding of tacrolimus high-producing strains by gamma-ray radiation and nitrosoguanidine mutagent[J].Journal of Radiation Research and Radiation Processing,2019,37(05):49-56.
严凌斌,张文州,张祝兰等.伽马射线辐射结合亚硝基胍诱变选育他克莫司高产菌株[J].辐射研究与辐射工艺学报,2019,37(05):49-56. DOI： 10.11889/j.1000-3436.2019.rrj.37.050401.

YAN Lingbin,ZHANG Wenzhou,ZHANG Zhulan,et al.Breeding of tacrolimus high-producing strains by gamma-ray radiation and nitrosoguanidine mutagent[J].Journal of Radiation Research and Radiation Processing,2019,37(05):49-56. DOI： 10.11889/j.1000-3436.2019.rrj.37.050401.

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Breeding of tacrolimus high-producing strains by gamma-ray radiation and nitrosoguanidine mutagent

DOI：10.11889/j.1000-3436.2019.rrj.37.050401