Radiobiology and treatment plan progress of FLASH radiotherapy

WU Xun; LIU Ruifeng; ZHANG Qiuning; WANG Xiaohu

doi:10.11889/j.1000-3436.2022-0074

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Radiobiology and treatment plan progress of FLASH radiotherapy

REVIEW | 更新时间：2023-04-20

- Radiobiology and treatment plan progress of FLASH radiotherapy
- Journal of Radiation Research and Radiation Processing Vol. 41, Issue 2, Pages: 20101(2023)
- 作者机构：
  
  1.中国科学院近代物理研究所兰州 730000
  2.兰州大学第一临床医学院兰州 730000
  3.兰州重离子医院兰州 730000
  4.中国科学院大学北京 100049
- 作者简介：
  
  WU Xun (male) was born in August 1991, and obtained his master's degree from North Sichuan Medical College in 2019. Now he is a graduate student at Lanzhou University
  WANG Xiaohu, professor, doctoral supurvisor, chief physician, E-mail: xhwang@impcas.ac.cn
- 基金信息：
  
  Key R&D Program of Science and Technology Department of Gansu Province(20YF8FA116);Talent Innovation and Venture Project of Lanzhou city(2020-RC-113);Program of Lanzhou Ion Therapy Co., Ltd(1100090020)
- DOI：10.11889/j.1000-3436.2022-0074
  CLC：
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WU Xun, LIU Ruifeng, ZHANG Qiuning, et al. Radiobiology and treatment plan progress of FLASH radiotherapy. [J]. Journal of Radiation Research and Radiation Processing 41(2):020101(2023)
DOI：

WU Xun, LIU Ruifeng, ZHANG Qiuning, et al. Radiobiology and treatment plan progress of FLASH radiotherapy. [J]. Journal of Radiation Research and Radiation Processing 41(2):020101(2023) DOI： 10.11889/j.1000-3436.2022-0074.

摘要

近年来，一项被称为FLASH放疗的新技术具有将辐射的治疗增益比推向一个新高度的潜力。FLASH放疗是一种以超高剂量率照射为主要特征的放疗技术，能显著减轻辐射对正常组织的损伤，同时保留辐射对肿瘤的杀伤能力。一方面，作为一种新兴的放疗技术，FLASH放疗的生物学机制尚未被阐明，这阻碍了其临床转化；另一方面，超高剂量率照射技术的临床应用也存在许多技术困难。本综述通过归纳FLASH放射生物学机制的研究进展，总结FLASH放疗治疗计划所面临的困难及可能的解决方案，旨在为后续FLASH放疗的临床转化提供参考。

Abstract

FLASH radiotherapy is a novel method that has the potential to improve the therapeutic gain ratio to a new level. FLASH radiotherapy technology is mainly characterized by irradiation at ultra-high dose rate, which can reduce radiation-induced injury to normal tissues during radiotherapy, while maintaining the ability of radiation damage to tumors. On the one hand, as a new radiotherapy technology, the radiobiological mechanisms of FLASH are unclear, which hinders its clinical transformation. On the other hand, there are many technical difficulties in the clinical application of ultra-high dose rate irradiation technology. This paper summarizes the research progress of radiobiological mechanisms underlying FLASH radiotherapy, as well as the challenges and possible solutions associated with FLASH radiotherapy treatment plans, to provide a reference for clinical translation of subsequent FLASH radiotherapy.

关键词

FLASH超高剂量率放疗放射生物学治疗计划

Keywords

FLASHUltra-high dose rateRadiotherapyRadiobiologyTreatment planning

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