Application value of liquid fiducial marker in image-guided radiotherapy

HUANG Yulin; YANG Haifang; JIANG Bin; ZHANG Wang; ZHANG Chao; LIU Jianping; TIAN Long

doi:10.11889/j.1000-3436.2023-0031

您当前的位置：

首页 >

文章列表页 >

Application value of liquid fiducial marker in image-guided radiotherapy

RADIOBIOLOGY AND RADIOMEDICINE | 更新时间：2023-10-27

- Application value of liquid fiducial marker in image-guided radiotherapy
- Journal of Radiation Research and Radiation Processing Vol. 41, Issue 5, Pages: 50302(2023)
- 作者机构：
  
  1.唐山市人民医院唐山 063000
  2.河北北方学院附属第一医院张家口 075000
- 作者简介：
  
  HUANG Yulin (male) was born in August 1991. Now he is working at the Tangshan People’s Hospital focusing on radiotherapy
  TIAN Long, master's degree, chief researcher, E-mail: 1277473912@qq.com
- 基金信息：
  
  Tangshan Key R & D Program(20211398)
- DOI：10.11889/j.1000-3436.2023-0031
  CLC：
扫描看全文
HUANG Yulin, YANG Haifang, JIANG Bin, et al. Application value of liquid fiducial marker in image-guided radiotherapy. [J]. Journal of Radiation Research and Radiation Processing 41(5):050302(2023)
DOI：

HUANG Yulin, YANG Haifang, JIANG Bin, et al. Application value of liquid fiducial marker in image-guided radiotherapy. [J]. Journal of Radiation Research and Radiation Processing 41(5):050302(2023) DOI： 10.11889/j.1000-3436.2023-0031.

摘要

评价一种可降解的液态基准标志物（Liquid fiducial marker，LFM）在图像引导放疗中的应用价值。体外实验：以固态基准标志物（Solid fiducial marker，SFM）为参考，评价不同锥形束CT管电压条件下LFM的可视性、伪影和最优注量。体内实验：以SFM为参考，评价LFM在裸鼠体内的稳定性和降解状况。将种植了肿瘤细胞的裸鼠随机分为未注入LFM的单次放疗组（16 Gy/次），注入了LFM的单次（16 Gy/次）、二分次（8 Gy/次）和四分次放疗组（4 Gy/次）。根据照射结果评价LFM对肿瘤生长的影响。相比SFM，LFM的伪影显著较小（均,p,<,0.05），可视性满足临床鉴别要求，当注量为10 μL时成像质量最佳。裸鼠体内LFM质心相对脊髓位移显著大于黄金基准标志物（（0.22±0.03） mm ,vs., （0.17±0.02） mm，,p,<,0.05），但始终小于一个像素尺寸，故稳定性良好。LFM的实际降解率同理论降解率高度相符。LFM对单次放疗组肿瘤生长影响较小，对分次放疗组影响较大。LFM具有一定临床应用和推广价值，未来有望取代SFM。

Abstract

This study was conducted to evaluate the application value of a degradable liquid fiducial marker (LFM) in image-guided radiotherapy. ,In vitro, experiment: using a solid fiducial marker (SFM) as a reference, the visibility, artifact, and optimal injection volume of an LFM under different cone beam CT tube voltage conditions were evaluated. ,In vivo, experiment: using the SFM as a reference, the stability and degradation status of the LFM in nude mice were evaluated. Nude mice implanted with tumor cells were randomly divided into four groups: single fraction radiotherapy group (16 Gy/fraction) without LFM injection, single fraction radiotherapy group (16 Gy/fraction) with LFM injection, 2 fractions radiotherapy group (8 Gy/fraction) with LFM injection, and 4 fractions radiotherapy group (4 Gy/fraction) with LFM injection. The impact of LFM on tumor growth was evaluated based on the irradiation results. Compared with SFM, the LFM artifacts were significantly smaller (all ,p,<,0.05), and the visibility met the clinical differentiation requirements. The best imaging quality was achieved when the injection volume was 10 μL. The displacement of the LFM centroid relative to the spinal cord in the nude mice was significantly greater than that of the gold fiducial marker ((0.22 ± 0.03) mm ,vs., (0.17 ± 0.02) mm,p,<,0.05); however, it was always smaller than a pixel size. The results indicated good stability. The actual degradation rate of the LFM was highly consistent with the theoretical degradation rate. The LFM had a relatively smaller impact on tumor growth in the single fraction radiotherapy group but a greater impact in the fractional radiotherapy groups. LFMs have certain clinical applications and promotional value, and they are expected to replace SFMs in the future.

关键词

液态基准标志物图像引导放疗应用价值

Keywords

Liquid fiducial markerImage guided radiotherapyApplication value

references

赵鑫, 田龙, 席强. 利用kV级CBCT识别标记物研究[J]. 中国医疗设备, 2019, 34(3): 41-44. DOI: 10.3969/j.issn.1674-1633.2019.03.012http://dx.doi.org/10.3969/j.issn.1674-1633.2019.03.012.

ZHAO Xin, TIAN Long, Ⅺ Qiang. Study on marker recognition using kV CBCT[J]. China Medical Devices, 2019, 34(3): 41-44. DOI: 10.3969/j.issn.1674-1633. 2019.03.012http://dx.doi.org/10.3969/j.issn.1674-1633.2019.03.012.

闫洁诚, 田龙, 胡逸民. 膀胱癌放疗中两种图像引导方法校准精度比较[J]. 北京生物医学工程, 2021, 40(3): 303-308. DOI: 10.3969/j.issn.1002-3208.2021.03.013http://dx.doi.org/10.3969/j.issn.1002-3208.2021.03.013.

YAN Jiecheng, TIAN Long, HU Yimin. Comparing the calibration accuracy of two image guided methods in bladder cancer radiotherapy[J]. Beijing Biomedical Engineering, 2021, 40(3): 303-308. DOI: 10.3969/j.issn. 1002-3208.2021.03.013http://dx.doi.org/10.3969/j.issn.1002-3208.2021.03.013.

Lei Y, Tian S, Tian Z, et al. Accurate CBCT prostate segmentation aided by CBCT-based synthetic MRI[J]. Medical Physics, 2019, 46(6): E132-E132.

Fontana F, Piacentino F, Ierardi A M, et al. Comparison between CBCT and fusion PET/CT-CBCT guidance for lung biopsies[J]. CardioVascular and Interventional Radiology, 2021, 44(1): 73-79. DOI: 10.1007/s00270-020-02613-3http://dx.doi.org/10.1007/s00270-020-02613-3.

田龙, 范学武, 许蕊, 等. 对比T2WI与T2*WI用于前列腺癌放射治疗计划的效果[J]. 中国介入影像与治疗学, 2022, 19(4): 239-244. DOI: 10.13929/j.issn.1672-8475. 2022.04.011http://dx.doi.org/10.13929/j.issn.1672-8475.2022.04.011.

TIAN Long, FAN Xuewu, XU Rui, et al. Comparison on T2WI and T2*WI for radiotherapy planning of prostate cancer[J]. Chinese Journal of Interventional Imaging and Therapy, 2022, 19(4): 239-244. DOI: 10.13929/j.issn. 1672-8475.2022.04.011http://dx.doi.org/10.13929/j.issn.1672-8475.2022.04.011.

Yang X, Fu Y, Lei Y, et al. Unsupervised learning-based CBCT-CT deformable image registration for CBCT-guided abdominal radiotherapy[J]. International Journal of Radiation Oncology*Biology*Physics, 2021, 111(3): e535-e536. DOI: 10.1016/j.ijrobp.2021.07.1459http://dx.doi.org/10.1016/j.ijrobp.2021.07.1459.

田龙, 席强, 赵鑫, 等. 膀胱癌图像引导放疗中基于软组织灰度值与基于内植标记物的锥形束CT校准比较[J]. 中国医学物理学杂志, 2018, 35(1): 31-35. DOI: 10.3969/j.issn.1005-202X.2018.01.007http://dx.doi.org/10.3969/j.issn.1005-202X.2018.01.007.

TIAN Long, XI Qiang, ZHAO Xin, et al. Comparison of cone beam computed tomography calibrations based on soft tissue grey value and implanted markers in image-guided radiotherapy for bladder cancer[J]. Chinese Journal of Medical Physics, 2018, 35(1): 31-35. DOI: 10. 3969/j.issn.1005-202X.2018.01.007http://dx.doi.org/10.3969/j.issn.1005-202X.2018.01.007.

Brown K H, Ghita M, Schettino G, et al. Evaluation of a novel liquid fiducial marker, BioXmark®, for small animal image-guided radiotherapy applications[J]. Cancers, 2020, 12(5): 1276. DOI: 10.3390/cancers12051276http://dx.doi.org/10.3390/cancers12051276.

托马斯 $\cdot$ https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=49145088&type=https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=49145100&type=0.423333352.28600001拉斯 $\cdot$ https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=49145088&type=https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=49145100&type=0.423333352.28600001安德列森, 拉斯马斯 $\cdot$ https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=49145088&type=https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=49145100&type=0.423333352.28600001艾尔明 $\cdot$ https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=49145088&type=https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=49145100&type=0.423333352.28600001约尔克, 莫腾 $\cdot$ https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=49145088&type=https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=49145100&type=0.423333352.28600001阿尔布雷克特森. 用于引导放射治疗的凝胶配方: CN105407927B[P/OL]. (2020-03-20) [2022-07-25]. https://doc.taixueshu.com/patent/CN105407927B.htmlhttps://doc.taixueshu.com/patent/CN105407927B.html.

Thomas R A, Rasmas E Y, Morten A. Formula of gel for guided radiotherapy: CN105407927B[P/OL]. (2020-03-20) [2022-07-25]. https://doc.taixueshu.com/patent/CN105407927B.htmlhttps://doc.taixueshu.com/patent/CN105407927B.html.

de Ridder M, Gerbrandy L C, de Reijke T Met al. BioXmark® liquid fiducial markers for image-guided radiotherapy in muscle invasive bladder cancer: a safety and performance trial[J].British Journal of Radiology, 2020, 93(1111): 20200241. DOI: 10.1259/bjr.20200241http://dx.doi.org/10.1259/bjr.20200241.

Machiels M, Voncken F E M, Jin P, et al. A novel liquid fiducial marker in esophageal cancer image guided radiation therapy: technical feasibility and visibility on imaging[J]. Practical Radiation Oncology, 2019, 9(6): e506-e515. DOI: 10.1016/j.prro.2019.06.018http://dx.doi.org/10.1016/j.prro.2019.06.018.

Rydhög J S, Mortensen S R, Larsen K R, et al. Liquid fiducial marker performance during radiotherapy of locally advanced non small cell lung cancer[J]. Radiotherapy and Oncology, 2016, 121(1): 64-69. DOI: 10.1016/j.radonc.2016.06.012http://dx.doi.org/10.1016/j.radonc.2016.06.012.

De Roover R, Crijns W, Poels K, et al. Characterization of a novel liquid fiducial marker for multimodal image guidance in stereotactic body radiotherapy of prostate cancer[J]. Medical Physics, 2018, 45(5): 2205-2217. DOI: 10.1002/mp.12860http://dx.doi.org/10.1002/mp.12860.

Kim H Y, Choi Y H, Lee S J. Effect of sedation anesthesia with intravenous propofol on transrectal ultrasound-guided prostate biopsy outcomes[J]. Journal of Korean Medical Science, 2022, 37(15): e115. DOI: 10. 3346/jkms.2022.37.e115http://dx.doi.org/10.3346/jkms.2022.37.e115.

Helrich S, Pate W, Garg N, et al. Comparison of magnetic resonance imaging to ultrasound for prostate sizing[J]. The Canadian Journal of Urology, 2021, 28(6): 10889-10899.

Takeda S, Fujimoto T, Onda K. Traumatic cervical vertebral artery dissection: a case with cerebral infarct due to newly formed thrombus in the cerebral arteries[J]. Neuropathology, 2020, 40(5): 501-506. DOI: 10.1111/neup.12664http://dx.doi.org/10.1111/neup.12664.

Xu C Y, Sun W G, Fang L Y, et al. The value of multimodal imaging in the diagnosis of primary cardiac angiosarcoma[J]. Echocardiography, 2021, 38(8): 1474-1477. DOI: 10.1111/echo.15156http://dx.doi.org/10.1111/echo.15156.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰