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Carbon ions inhibit non-small cell lung cancer cell proliferation by inducing mitochondrial damage
RADIOBIOLOGY AND RADIOMEDICINE | 更新时间:2024-08-26
    • Carbon ions inhibit non-small cell lung cancer cell proliferation by inducing mitochondrial damage

    • 在非小细胞肺癌治疗领域,研究团队通过A549细胞实验,发现碳离子照射能有效抑制肺癌细胞增殖。4 Gy剂量下,细胞增殖受到显著抑制,线粒体形态、膜电位发生改变,促凋亡蛋白释放,细胞凋亡率和线粒体自噬水平升高。清除线粒体后,碳离子失去促细胞凋亡作用。研究为肺癌治疗提供新思路。
    • Journal of Radiation Research and Radiation Processing   Vol. 42, Issue 4, Pages: 64-74(2024)
    • DOI:10.11889/j.1000-3436.2024-0013    

      CLC: Q279
    • Published:20 August 2024

      Received:07 March 2024

      Revised:07 April 2024

      Accepted:07 April 2024

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  • ZHANG Tianyi, YANG Pengfei, WANG Jufang, et al. Carbon ions inhibit non-small cell lung cancer cell proliferation by inducing mitochondrial damage[J]. Journal of Radiation Research and Radiation Processing, 2024, 42(4): 040301. DOI: 10.11889/j.1000-3436.2024-0013.

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