Al<sup>18</sup>F labeling process for NOTA-octreotide based on digital microfluidic chips

WANG Feihong; CHEN Junwei; YAO Qiong; MAO Dilong; JIN Chentao; GONG Yide; PAN Jianzhang; ZHANG Hong; WANG Jing; HE Qinggang

doi:10.11889/j.1000-3436.2025-0021

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Al¹⁸F labeling process for NOTA-octreotide based on digital microfluidic chips

RADIOBIOLOGY AND RADIOMEDICINE | 更新时间：2025-10-21

- Al¹⁸F labeling process for NOTA-octreotide based on digital microfluidic chips
- “This study proposes a new synthesis process for 18F-AlF NOTA octreotide based on digital microfluidic chips, which effectively solves the problems of technical complexity, high cost, and low production efficiency in traditional synthesis methods. It provides an efficient, low-cost, and environmentally friendly new strategy for the synthesis of clinical PET tracers.”
- Journal of Radiation Research and Radiation Processing Vol. 43, Issue 5, Pages: 50301(2025)
- 作者机构：
  
  1.杭州吉蕊科技有限公司杭州 310015
  2.浙江大学化学工程与生物工程学院杭州 310058
  3.浙江大学医学院附属第二医院核医学科及PET-CT中心杭州 310009
  4.浙江大学化学系杭州 310058
- 作者简介：
  
  WANG Feihong (male) was born in 1998, obtained a bachelor of engineering degree from Wenzhou University in 2020, research field: mechanical engineering
  ZHANG Hong, E-mail: hzhang21@zju.edu.cn
  HE Qinggang, E-mail: qghe@zju.edu.cn
- 基金信息：
  
  National Natural Science Foundation of China(32027802;22178307);the National Key R&D Program of China(2021YFA1101700);the Science Technology Department of Zhejiang Province(2024C03100;2022C03071)
- DOI：10.11889/j.1000-3436.2025-0021
  CLC： TL92⁺3
- Received：04 March 2025，
  
  Revised：2025-06-30，
  
  Accepted：30 June 2025，
  
  Published：20 October 2025
- 稿件说明：
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王飞鸿, 陈俊威, 姚琼, 等. 基于数字微流控芯片的NOTA-奥曲肽的Al¹⁸F标记工艺[J]. 辐射研究与辐射工艺学报, 2025, 43(5): 050301.

WANG Feihong, CHEN Junwei, YAO Qiong, et al. Al¹⁸F labeling process for NOTA-octreotide based on digital microfluidic chips[J]. Journal of Radiation Research and Radiation Processing, 2025, 43(5): 050301.
王飞鸿, 陈俊威, 姚琼, 等. 基于数字微流控芯片的NOTA-奥曲肽的Al¹⁸F标记工艺[J]. 辐射研究与辐射工艺学报, 2025, 43(5): 050301. DOI： 10.11889/j.1000-3436.2025-0021. CSTR： 32195.14.j.JRRRP.1000-3436.2025-0021.

WANG Feihong, CHEN Junwei, YAO Qiong, et al. Al¹⁸F labeling process for NOTA-octreotide based on digital microfluidic chips[J]. Journal of Radiation Research and Radiation Processing, 2025, 43(5): 050301. DOI： 10.11889/j.1000-3436.2025-0021. CSTR： 32195.14.j.JRRRP.1000-3436.2025-0021.

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Al18F labeling process for NOTA-octreotide based on digital microfluidic chips

DOI：10.11889/j.1000-3436.2025-0021

Al¹⁸F labeling process for NOTA-octreotide based on digital microfluidic chips