最新刊期
      期 5 ， 2009
      • YU Dahai,TIAN Ye
        Vol. 27, Issue 5, Pages: 257-260(2009)
        摘要：Radiotherapy is a important treatment method for primary and metastatic cancers in the brain. However, a high dose of radiation always leads to the brain injury. A representative pathological manifest of the radiation-induced brain impairment is demyelination. Therefore oligodendrocytes, the myelin-forming cells in the central nervous system, have been focused more attention recently. Oligodendrocytes originate from the migratory, mitotic progenitors and mature progressively into postmitotic myelinating cells. Recent years, a series of studies have been initiated to address the role of oligodendrocyte lineage cells in radiation-induced neurotoxic processes. This article pays attention to these studies, aiming to explore mechanisms of the radiation-induced brain impairment.  
        关键词：Oligodendroglial lineage cells;Demyelination;Radiation;Radiation-induced brain impairment   
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        发布时间：2023-03-30
      • WANG Feng,TONG Bin
        Vol. 27, Issue 5, Pages: 261-264(2009)
        摘要：γ-rays irradiation was used to graft monomers vinyltrjmethoxysilane onto polypropylene powders and then the obtained PP-g-Si was hydrolyzed to get cross-linking. In this paper, the effects of the absorbed dose on the grafting degree of the monomer vinyltrjmethoxysilan and gel content of the cross-linked samples were investigated. Adding the styrene as the second monomer can make grafting ratio up to 4.2%. The grafting ratio increases with the increment of absorbed dose, while gel content of the cross-linked samples induced by hydrolysis does not increase simultaneously. Because the irradiation can cause the molecular main-chain broken, melting flow rates (MFR) of PP-grafting-vinyltrjmethoxysilane decreases. The melting temperature of PP-g-Si has been investigated by DSC and crystal structure of PP-g-Si has also been studied by use of XRD.  
        关键词：γ-ray irradiation;Grafting;Polypropylene;Vinyltrimethoxysilane   
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        发布时间：2023-03-30
      • DU Fuqiang,LIU Yuxia,TU Tiecheng,LIN Weizhen
        Vol. 27, Issue 5, Pages: 265-268(2009)
        摘要：In order to study the reaction of triplet state of VK3 with nucleic acid derivatives, the ESR (Electron spin resonance) spin elimination has been used with 4-oxo-TEMPO as spin trap. The reactivities of 3VK3* with nucleosides, nucleotides, and models of telomeric DNA, template of telomerase RNA and its L6-P6 region have been confirmed respectively. The results show that the tendency of reaction of 3VK3* with nucleosides is Gua>Ade>Cyt>Thy, meanwhile dGMP>dAMP>dCMP> TMP for reaction of 3VK3* with deoxy-nucleotides, and the one for reaction of 3VK3* with telomeric DNA is the highest in polynucleotides. This is highly accordant with both of their corresponding rate constants determined by laser flash photolysis and their oxidation-reduction potentials. It also shows that the reactivity of 3VK3* with polynucleotides is directly proportional to their G amount.  
        关键词：2-methyl-1;4-naphthoquinone;Excited triplet state;ESR spin elimination   
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        发布时间：2023-03-30
      • FENG Guangwen,HU Youhua,LIU Qian
        Vol. 27, Issue 5, Pages: 269-274(2009)
        摘要：In this paper, the application of the entropy weight TOPSIS method to optimal layout points in monitoring the Xinjiang radiation environment has been indroduced. With the help of SAS software, It has been found that the method is more ideal and feasible. The method can provide a reference for us to monitor radiation environment in the same regions further. As the method could bring great convenience and greatly reduce the inspecting work, it is very simple, flexible and effective for a comprehensive evaluation.  
        关键词：Entropy weight;Technique for order preference by similarity to ideal solution (TOPSIS);Radiological environment;Optimal layout points   
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        发布时间：2023-03-30
      • HA Yiming,JU Hua,WANG Feng,FAN Bei,LIU Shuliang
        Vol. 27, Issue 5, Pages: 275-279(2009)
        摘要：The growth of pathogenic bacteria during storage time and their D10 values by irradiation in cooled chicken were evaluated. The total numbers of colony, E. coli 10003, Campylobacter jejuni33560 and CY04 of the D10 values were 1.434 kGy, 0.408 kGy, 0.175 kGy, 0.2 kGy respectively in cooled chicken. The results show that total bacteria count in vacuum packaged cooled chicken sample is 5.66lg (CFU/g) and 4.90lg (CFU/g) after 3 kGy and 5kGy irradiation. And in storage at 0~4℃ the storage shelf-life of irradiated vacuum packaged cooled chicken could extend to 21 d and 28 d. It can be deduced that pathogenic bacteria can be controlled effectively by irradiation.  
        关键词：Cooled chicken;Pathogenic bacteria;D10 values;Storage time   
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        发布时间：2023-03-30
      • SONG Shengnan,ZHANG Wei,ZHANG Zhicheng
        Vol. 27, Issue 5, Pages: 280-288(2009)
        摘要：Monodisperse carboxyl-functionalized polystyrene particles size with range of 0.6~2.1μm were synthesized by two-stage radiation-induced dispersion polymerization of styrene in ethanol/water media using poly (vinylpyrrolidone) (PVP) as the stabilizer and itaconic acid (IA) as a functional comonomer. The resulting carboxylated polystyrene (PS) particles have a narrower size distribution compared with those obtained by one-stage dispersion polymerization. In the two-stage method, the presence of additional IA in the second reaction stage may help to prevent secondary nucleation and to promote the formation of monodisperse particles. The effects of concentration of IA, PVP and solvent polarity on the particle size and size distribution have been discussed in detail. The carboxyl group density on the surface of the copolymer particles has been determined directly by conductometric titration. In order to examine the functionality of the particles, P(St-co-IA)/Co composite microspheres are prepared by repetitious interface reduction reactions.  
        关键词：Radiation polymerization;Dispersion polymerization;Carboxylation;Polystyrene   
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        发布时间：2023-03-30
      • Xu Qian,Jin Zongda,Dong Liang,Tong Jian,Cao Yi
        Vol. 27, Issue 5, Pages: 289-296(2009)
        摘要：In order to explore the effects of low dose microwave on mice hematopoietic injuries induced by γ-rays irradiation, male Kunming mice were treated randomly with control, the microwave, the γ-rays irradiation and microwave combined with γ-rays irradiation respectively. The microwave group and combined group were pre-exposed to 120 μW/cm2 microwave with 1h/d and sustained 14 days. And the γ-rays irradiation and combined group were further exposed to 5.0 Gy of 60Co γ-ray radiation at the 15th day. Animals were sacrificed at the 3, 6, 9 and 12 day after irradiation. The sternum and spleen paraffin section were produced and the pathological changes were quantitatively obtained. The results show that bone marrow is obviously injured either by γ-rays or combined radiation, which is characterized by undergoing four-phase lesions, namely apoptosis-necrosis, void, regeneration and recovery phase. Compared to γ-rays group, the pathological changes in combined group are slighter and the recovery is quicker. The spleen coefficient of combined group is significantly higher than that of the γ-rays group at the 9th and 12th day after irradiation (p<0.05). The pathological changes of spleen are similar to that of bone marrow. All these injuries in the combined group are lighter than that in the γ-rays group. It has been demonstrated that pre-exposure with low dose microwave could reduce the γ-rays hematopoietic damage in this experimental conditions.  
        关键词：Microwave;γ-rays;Mice;Hematopoietic system   
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        发布时间：2023-03-30
      • PAN Jianru,ZHOU Jinghong,PENG Shumei,HE Huocong,LIU Shutao,RAO Pingfan
        Vol. 27, Issue 5, Pages: 297-302(2009)
        摘要：The oxidized damage models of the skins of guinea pigs caused by single dose and repeating UVB radiation were established. The preventive effects of recombinant protein PTD-SOD1 and PTD-SOD2 compared with wide-type SOD on the oxidized damage of ultraviolet B radiation were then studied. The color change of the skins of the back of guinea pigs were recorded with a digital camera and analyzed with Photoshop software. The degree of erythema was evaluated by measuring the a* value which indicated the amount of redness in the skin. An increment of a* values indicates the development of erythema. It has been proved that compared with wide-type SOD, both PTD-SOD1 and PTD-SOD2 can well prevent the damage of the skin of guinea pigs by single dose UVB radiation and PTD-SOD2 is the better one. The bell-shaped dose–response curves can be seen when the oxidized damage of guinea pigs is caused by single dose ultraviolet B radiation and protected by exogenous PTD-SOD. The two PTD-SOD proteins are effective in prevention of cutaneous damage caused by UVB irradiation when the guinea pigs are administered 2000 U proteins 0.5 h before irradiation, beyond which protection is lost and injury is even exacerbated. The PTD-SOD proteins have been proved to have a far better protective effect than that of wild-type SOD on repeating ultraviolet B radiation too. The results are confirmed by the histomophological analysis of the guinea pigs skin.  
        关键词：PTD;SOD;UVB radiation damage;Preventing effect;Guinea pigs   
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        发布时间：2023-03-30
      • HUANG Juan,BAO Xiaodan,LAI Qiang,MA Jianhua
        Vol. 27, Issue 5, Pages: 303-308(2009)
        摘要：The effects of photosensitizer quinones -2 - sodium anthraquinone (AQS) and 2-methyl-1, 4-naphthoquinone (MQ) on blocking synthesis of nitrosamine were studied by ultraviolet photolysis and compared with the same conditions of ascorbic acid (Vc). The effects of determination conditions such as concentrations, reaction time and ultraviolet radiation wavelengths on blocking nitrosamines by AQS、MQ were investigated. The results show that when reaction time is 1h, quinone concentration is 0.96 mmol/L, ultraviolet radiation wavelengths is 365 nm, their blocking rate could reach the highest value. The blocking capability followed by MQ> AQS> Vc. In the meantime, their cleaning action of nitrite has been determined by spectrophotometer, it has been found that under the same condition, their cleaning ability of nitrite followed by Vc > MQ > AQS.  
        关键词：Anthraquinone (AQS);Naphthoquinone (MQ);Blocking systhesis of nitrosamines;Ultraviolet photolysis   
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        发布时间：2023-03-30
      • NI Liqin,ZHANG Jianwei
        Vol. 27, Issue 5, Pages: 309-311(2009)
        摘要：In order to improve detection of hot water extraction from paper raw material, microwave heating is used in paper raw material test instead of the water-bath heating. Two main factors for efficiency of hot water exaction: irradiation power and time are carefully studied. Experiment results show that when hot water exaction from 2 g straw powder is tested, microwave heating with 400~600 W irradiation power and 4~6-minute irradiation time can achieve the same efficiency as water-bath heating with 180-minute time. Many experiments confirm that microwave heating improves the efficiency of detecting tests greatly and the method is also reproducible.  
        关键词：Microwave;Paper raw material;Detection of extraction   
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        发布时间：2023-03-30
      • YUE Ling,YANG Zhanshan,YANG Shuqin,LI Qinghua
        Vol. 27, Issue 5, Pages: 312-316(2009)
        摘要：A hydrogel film of drug sustained-release was prepared to accelerate wound healing. The hydrogel films containing drug or not were prepared by the freezing and thawing process. Their properties such as the physicochemical property and the drug release behavior in vitro were studied. Effect of the freezing and thawing process on antimicrobial efficacy of the gentamicin was evaluated by diffusion method. The results indicate that swelling ratio of the hydrogel films freezed for 4h is 841.21% and their gel fraction, tensile strength and elongation at break is 96.10%, 0.222 MPa and 673.50% respectively. The antimicrobial efficacy of the gentamicin has no change. The hydrogel film contained gentamicin releases the antibiotic to peak during 6 h with the cumulative drug release rate of 59.57%. The drug releases continually up to the 5th day. The drug delivery conforms to Higuchi kinetic equation, and mechanism of the drug release is matrix diffusion. The results show that the hydrogel film prepared by the freezing and thawing process display satisfactory physicochemical properties and can be used as a drug delivery system.  
        关键词：Hydrogel films;Freezing-thawing process;Sustained release property;Drug delivery   
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        发布时间：2023-03-30
      • CUI Fengmei,HU Mingjiang,BAO Guangliang,SUN Liang,WANG Daojin,TONG Jian
        Vol. 27, Issue 5, Pages: 317-320(2009)
        摘要：To study the internal radiation effects of tritiated water on the amount of cells of peripheral white blood cell (WBC) and micronucleus rate of polychromatic erythrocytes (MNPCE) in mice, C57BL/6J mice were randomly divided into several groups: one control group, two groups with injection of different initial concentration of T2O, and five groups with injection of same initial concentration of T2O, but different time for sacrifice (i.e. the 2nd, 4th, 6th, 10th and 28th day after injection). The amount of peripheral WBC and MNPCE were measured. In different initial concentration groups, the MNPCE in bone marrow increases (p<0.05) with increment of cumulative doses. The amount of peripheral WBC of the group with initial concentration of 16.65×105Bq/g is higher than that of the other groups. In the same initial concentration groups, the total number of peripheral WBC decreases (p<0.05) before the 6th day and recovers at the 10th day after injection. The MNPCE increases continuously to the 28th day after injection. The amount of peripheral WBC and the MNPCE in bone marrow can be used as early sensitive indicators for internal exposure to tritium irradiation.  
        关键词：Tritium oxide;Mouse;Peripheral white blood cell;Polychromatic erythrocytes;Micronuclei   
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        发布时间：2023-03-30
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