摘要:Kinetics and mechanisms of dechlorination of chlorinated organic pollutants induced by ionizing radiation were described in this article. The progress on the dechlorination of chlorophenols, polychlorinated biphenyl, trichloroethylene, and perchloroethylen involved in radiolysis was also reviewed. In oxidative condition, hydroxyl radical (·OH) would attack chlorophenol to form ·OH-adducts, which could be dechlorinated gradually. However, chlorophenol can be directly reduced by hydrated electron(e-aq) to release Cl﹣. It was found that radiolytical degradation of polychlorinated biphenyls in organic solvent would release chlorine atoms gradually by chain reactions and the final products were Cl﹣and biphenyl. Trichloroethylene and tetrachloroethylene mainly reacted with ·OH with the final products of CO2, HCOOH and HCl. As conclusion, the reductive dechlorination of chlorinated organic pollutants possesses advantages of high degradation efficiency, simple products and relatively low radiation dose compared with the oxidation methods.
摘要:As one of the 21-Century high and new technologies, nanotechnology (NT) has been widely applied in all aspects of biology. From now on, it has been used for detecting substance, carrying drug, antibacterial and tumour therapy by its photometric characteristics, mechanics characteristics, thermal property and other characteristics. Because of the unique advantages of nanoparticles, nanotechnology has great potential in radioprotection. In this article, we introduced the application of nanotechnology in modern biology and the primal problems. Meantime, we explain the prospect of its application in radioprotection.
关键词:Nanoparticles;Physical and chemical property;Application;Radiation protection
摘要:Methylacrylic acid (MAA), acrylonitrile (AN), acrylamide (AM) and methyl methacrylate (MMA) were polymerized by γ-rays, and AN/AM/MAA copolymer as well as polymethylmethacrylate (PMMA) were synthesized. Then microporous structure of polymethacrylimide (PMI) was obtained by the degradation of PMMA using heat-treatment. FIIR spectra showed that imide process and PMMA degradation were simultaneous at the selected temperature. TG-DSC analysis showed that the sample began to degrade at 345℃. And SEM photos indicated that microporous PMI with obturator foramen structure was obtained, whose aperture was about 100 µm.
TI Youzhou,LÜ Xiaohua,SONG Weiqiang,DENG Gang,GUO Zhengchao
Vol. 29, Issue 6, Pages: 336-340(2011)
摘要:The effect of the mass ratio of acrylamide (AM) to dimethyl dially ammonium chloride (DMDAAC) on the graft copolymerization of starch and mixtures of DMDAAC and AM was investigated at dose of 3 kGy in aqueous solution. The cationic degrees of grated products is 24.3%, 19.4% and 23.1% with 0.25, 1.5 and 1.86(WAM: WDM), respectively. And the graft efficiency of DMDAAC onto starch increases with the increment of the amount of AM in mixtures and the maximum value occurs at WAM: WDM=1.86. The total graft yield, the total graft efficiency, the monomer conversion rate and the production rate increase with the amount of AM in mixtures.
SONG Weidong,ZHU Jun,ZHAO Huidong,ZHANG Hongna,GUO Dongquan,LIU Kebo,ZHOU Jie,QUAN Yanjun,WANG Wanli
Vol. 29, Issue 6, Pages: 341-344(2011)
摘要:In order to improve the safety performance of a γ-irradiator to meet related standards, an interlock system based on programmable logic controller was designed. By the ladder diagram design, the system realized the sequential inspection, delay timer, exception alarm and son on. The results show that the programmable flexible design is advantageous in improving safety of the irradiator.
摘要:Polypropylene/montmorillonite composite was prepared via melt compounding process. The dispersion of montmorillonite in the composite was analized by XRD (X-ray deffraction) and TEM (Transmission electron microscope). Electronic radiation was applied to make the composite radiation closs-linked in air. The effect of cross-linking agent and montmorillnite on the properties of polypropylene cross-linking was studied. The results indicated that cross-linking did not take place in absence of cross-linking agent, while in presence of both cross-linking agent and montmorillonite polypropylene cross-linking occurred in certain absorbed dose range. The cross-linked polypropylene/momtmorillnite composite exhibited improved mechanical properties.
摘要:In order to explore the radio-protective mechanism of treatment with nitroxides R-1 on the human liver cell L-02 was used as a model of target, and L-02 cells were divided into the control, drug, irradiation and combination groups. The samples of drug and irradiation groups were given 0.25 μmol / L of R-1 and exposed to 4 Gy of 60Co γ-rays irradiation respectively; the combination group received both treatments; whereas there was no any treatment with the control group. The cell cycle was measured by flow cytometry; the enzyme activity of SOD and GSH was detected by chemiluminescence and spectrophotometric method, respectively meanwhile the concentration of MDA and ROS was measured by TBA and DCFH-DA, respectively. The expression of p53, Bcl-2, Bax and caspase-3 protein was observed by western blot. The results show that compared with irradiation group, the G2 cell cycle arrest was relieved (determined at 48 h, G2 phase proportion of the cell was (29.4±3.40):(44.01±2.71); t=6.46, p<0.05, the enzyme activity of SOD was (97.03±5.99): (50.94±5.47); t=9.84, p<0.05 and GSH was (16.56±0.91): (7.49±0.54); t=14.81, p<0.05 meanwhile the concentration of MDA was (2.87±0.33): (4.93±0.17); t=9.56, p<0.05 and ROS was (45.33±3.79): (75.67±4.7); t=8.67, p<0.05. It was found that the expression of p53, Bax and caspase-3 decreased significantly, while the expression of Bcl-2 increased in the combination group. This experiment indicates that nitroxides R-1 can protect the L-02 cell from radiation damage effectively by removing the free radical in cells.
关键词:Nitroxides;Human liver cells;γ-rays;P53 protein
摘要:To detect the metabolic profile of rats urinary by use of 1H-NMR, the rats were irradiated by 60Co γ-rays with a dose of 7 Gy (0.7 Gy/min). And the data was processed by principal components analysis (PCA) and partial least square discriminate analysis (PLS-DA). The results demonstrated that there were obvious differences in urine metabolites before and after irradiation, and the main metabolites included lactate, acetate, succinate, citrate, creatinine, trimethylamine-N-oxide and taurine. The relative content of lactate, acetate, creatinine and trimethylamine-N-oxide increased significantly on the first day following quickly decreasing on the second and third days, but increasing on the fourth day after irradiation. On the first three days after irradiation, the relative content of succinate and citrate had trending down, but had an ascending tendency on the fourth day. The relative content of taurine was basically stable but higher than pre-radiation. In conclusion, 1H-NMR combined with PCA and PLS-DA provides a good research method to detect the urinary metabolic profile in rats before and after irradiation.
关键词:Acute total body homogeneous irradiation;Urinary metabolites;Nuclear resonance spectroscopy;Principal component analysis
摘要:The effect of percentage depth dose (PDD) and total scatter factor should be inspected in clinical prescription dose calculation. In this study, the simulation of SIEMENS Primus Plus accelerator and calculation of the total scatter calibrate factor (Sc, p) and percentage depth dose (PDD) of 6MV electron beam energy was made by use of Monte-Carlo method (BEAMnrc and DOSXYZnrc). And the results were compared with the measured one by use of thimble chamber. What’s more, the effect of radiation field and depth on total scatter calibrate factor (Sc, p) of linear accelerator was also calculated in Monte-Carlo method. The results show that the total scatter calibrate factor (Sc, p) increases with increment of field size and the scatter calibrate factor (Sc, p) increases with the increment of depth when field size is larger than 10 cm×10 cm. However, the total scatter calibrate factor (Sc, p) decreases with the increment of depth when field size was smaller than 10 cm×10 cm. It has been confirmed that Monte-Carlo method can establish a comprehensive and accurate information on the scatter calibrate factor for clinical radiotherapy, which may provide more realizable quality assurance and control.
摘要:To investigate the pathological damage of lung and peripheral blood damage in rats exposed to radon and its progeny, Sprague-Dawley rats were exposed to radon in multifunction ecological radon chamber with the cumulative dose up to 60, 90 and 120 WLM, respectively. The numbers and proportions of white cells in peripheral blood were measured meanwhile the degree of lung and its bronchus injury was observed. It was found that proportions of white blood cells increased in the proportion of granulocytes and decreased in the proportion of lymphocytes (p<0.05). A series of pathological alterations were observed including hyperaemia and edema in the alveolus, emphysema, infiltration of inflammatory cells. The occurrence of different pathology, its scope and the serious degree, alveolar capillaries and incidence of thrombosis increased with the accumulation exposure dosage. As a result, radon and its progeny can increase the proportion of granulocytes and decrease the proportion of lymphocytes in peripheral blood cells. At the same time the serious degree of lung and its bronchus injury will increase with the increment of the accumulation exposure dosage.
摘要:The blood compatibility of the radiation sterilized disposable burette tansfusion apparatus was investigated to provide evidence for the safety of radiation sterilized medical devices. The initial bacteria burden of the disposable burette transfusion apparatus was examined according to the ISO11737 standard, and the whole blood clotting time, prothrombin time, partial thromboplastin time and hemolysis rate of the samples were determined. There was no significant difference between the radiation sterilized samples and negative controls on WBCT, PT and PTT (p>0.05). Haemolysis test showed that the haemolysis rate of the sample sterilized by irradiation was 1.38%, which was coincidence with the criteria of the medical devices. After sterilization by irradiation, disposable burette transfusion apparatus show good blood compatibility, which could be considered that radiation sterilization is a biologically safe method for the medical apparatus.