最新刊期
      期 5 ， 2015
      • WANG Lu,XU Chang,WANG Yan,DU Liqing,WANG Qin,LI Qing,LIU Qiang
        Vol. 33, Issue 5, Pages: 50201-050201(2015) DOI: 10.11889/j.1000-3436.2015.rrj.33.050201
        摘要：We aim to investigate the effect of resveratrol on inflammatory factor IL-6 produced in irradiated mesenchymal stem cells（MSCs） and explore the radioprotective effect of resveratrol. MSCs were treated with different concentrations of resveratrol before irradiation, and the expression of IL-6 was detected by ELISA, Western-blot, and RT-PCR. The results showed that ionizing radiation can lead to the increasing of IL-6 expression in MSCs, and resveratrol can inhibit the expression of ionizing radiation-induced IL-6. Resveratrol can inhibit the ionizing radiation-induced expression of inflammatory cytokines IL-6, which suggests that Sirt1 may play a key role in the process of inflammation induced by irradiation.  
        关键词：Resveratrol;Mesenchymal stem cells（MSCs）;Inflammatory factor IL-6;Ionizing radiation;Radiation protection   
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        发布时间：2022-09-27
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