最新刊期
卷 43 ， 期 4 ， 2025
- “在癌症治疗领域，小分子增敏剂的研究取得新进展，有望提高放疗疗效并减少副作用。”摘要：As a crucial and frequently utilized modality in cancer treatment, the efficacy of radiotherapy is often limited by both the intrinsic radioresistance of tumor cells and radiation-induced damage to healthy tissues. In recent years, small-molecule radiosensitizers for radiotherapy have become an increasingly popular research focus, owing to their distinct advantages, including low molecular weight, highly controllable synthesis, and precise targeting capabilities. This article aims to systematically review the classification and current research status of small-molecule radiosensitizers, with a focus on elucidating the mechanisms of action and latest research progress of different types of small-molecule radiosensitizers, including DNA damage repair inhibitors, hypoxia-targeting agents, reactive oxygen species modulators, and epigenetic regulators. These small-molecule radiosensitizers effectively enhance the radiosensitivity of tumor cells by precisely intervening in their biological processes, thereby significantly improving the efficacy of radiotherapy. With a deeper understanding of tumor resistance mechanisms and oxidative stress, small-molecule radiosensitizers show broad application prospects in reducing radiotherapy-related side effects and increasing selectivity for specific tumor cells and are expected to bring breakthroughs to the field of cancer radiotherapy.关键词：Radiotherapy;Small molecule sensitizers;DNA damage repair;Hypoxia targeting;Reactive oxygen species regulation77|62|0更新时间：2025-08-21
REVIEW
- “最新研究发现，将香豆素基前荧光氮氧自由基引入硅橡胶，可实现辐射老化防护与监测，提升硅橡胶在辐射环境中的可靠性。”摘要：Silicone rubber is widely used in radiation environments, such as the nuclear industry and aerospace, due to its excellent properties. However, irradiation can cause performance degradation. This study proposes the introduction of coumarin-based profluorescent nitroxide radicals (PC343) into silicone rubber to achieve both radiation aging protection and sensitive monitoring. PC343 was uniformly introduced into silicone rubber (SR-P) via a swelling method. Electron paramagnetic resonance spectroscopy confirmed that PC343 reacts with radiation-generated free radicals in silicone rubber, demonstrating free radical scavenging ability. Gas-phase infrared spectroscopy analysis showed that PC343 could reduce the production of alkane gases (the alkane yield of SR-P irradiated at a dose of 1 kGy was approximately 40% lower than that of pure silicone rubber), indicating its radiation protection effect. Fluorescence spectra revealed that PC343 regained strong fluorescence characteristics through radical capture. The fluorescence intensity of SR-P increased with the increasing dose after irradiation, and the aging behavior from 500 Gy to 5 kGy could be sensitively characterized. The experiments demonstrated that the introduction of PC343 simultaneously achieves dynamic protection against irradiation aging and real-time monitoring in silicone rubber. This strategy provides a novel approach for improving the service reliability of silicone rubber in radiation environments.关键词：Silicone rubber;Radiation-induced aging;Sensitive monitoring;Profluorescent nitroxide56|236|0更新时间：2025-08-21
- “磁性金属有机框架气凝胶高效吸附核医学废水中镥-177，为核废料处理提供新方案。”摘要：In this study, a magnetic metal-organic framework amyloid fibril (M-UiO-66-NH2/AF) aerogel was synthesized for the efficient adsorption of lutetium-177 from nuclear medicine wastewater. The morphology, structure, and composition of the aerogel were characterized comprehensively using atomic force microscopy, transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, vibrating sample magnetometry, and physical adsorption analysis. The results showed that the aerogel possesses a uniform and highly porous structure, is ultralight yet robust, and has a density of approximately 30 mg/cm3. It afforded a maximum absorption rate of 92% for Lu-DOTA-TATE and reached adsorption equilibrium within 60 min. Its adsorption kinetics was consistent with the pseudo-second-order model, wheras its adsorption isotherm data conformed to the Langmuir model, with a maximum adsorption capacity of 0.37 mg/g.关键词：Metal-organic framework;Amyloid fibril;Aerogel;Adsorption;Lu-DOTA-TATE57|192|0更新时间：2025-08-21
- “在辐射防护领域，研究了三种自由基捕捉剂对EVA材料性能的影响，发现DIP能有效延缓EVA的辐射老化，为辐射防护材料研究提供新思路。”摘要：The effects of three types of free radical scavengers such as N, N'-di-sec-butyl-p-phenylenediamine (44PD), tert-butylhydroquinone (TBHQ) and diisopropyl xanthate disulfide (DIP) on the structural evolution and properties changes of ethylene vinyl acetate copolymers (EVA) under γ-ray irradiation were investigated. Thermogravimetric analysis (TGA) results showed that the free radical scavengers could inhibit the cleavage of polyethylene chain segments in EVA at higher absorbed doses. The results of gel content and stress relaxation tests showed that the three antioxidants or stabilizers could inhibit the construction of the internal cross-linking structure of EVA, in which the inhibitory effect of the amine antioxidant 44PD was relatively insignificant. However, when the absorbed dose was higher, the EVA containing the free radical scavenger had a more complete cross-linking structure and a lower rate of stress relaxation. The mechanical properties test results indicate that all three free radical scavenger can inhibit the irradiation-induced aging of EVA, among which DIP is more effective. The retention rate of the elongation at break of EVA at an absorbed dose of 500 kGy is 68%, while a retention rate of 96% of the elongation at break is reached at the same absorbed dose with the addition of 1% DIP.关键词：Gamma rays;Irradiation-induced aging;Ethylene-vinyl acetate copolymer;Free radical scavenger;Mechanical properties95|54|0更新时间：2025-08-21
RADIATION CHEMISTRY
- “最新研究发现，X射线刺激心肌成纤维细胞中lncR-TUG1表达，驱动初级纤毛形成，促进心肌纤维化。”摘要：The aim is to evaluate the effect of lncR-TUG1 in myocardial fibroblasts and primary cilia on X-ray induced myocardial damage. Wistar rats were subjected to a single dose of 8 Gy whole-body irradiation, and were euthanized by cervical dislocation. HE and Masson staining were performed. Myocardial fibroblasts were isolated by double enzyme digestion and differential adhesion methods. shRNA targeted lncR-TUG1 and IFT88 were transfected into myocardial fibroblasts in the X-ray group. Immunofluorescence was used to detect primary cilia in myocardial tissue and myocardial fibroblasts. qPCR and western blot were used to detect the relative gene and protein levels of lncR-TUG1, IFT88, TGFβ1, and Col1α, respectively. The results showed that compared with the control group, X-ray radiation stimulated the expression of lncR-TUG1, primary ciliary assembly, inflammatory infiltration, and collagen deposition in rat myocardial tissue. X-ray radiation increased the expression of lncR-TUG1 and primary ciliary assembly in myocardial fibroblasts. After silencing lncR-TUG1, the assembly of primary cilia in cardiac fibroblasts decreased (p<0.01). After silencing IFT88, the secretion of TGFβ1 and Col1α in cardiac fibroblasts decreased (p<0.05). X-ray radiation induced the expression of lncR-TUG1 in myocardial fibroblasts, lncR-TUG1 drove the assembly of primary cilia, and promoted X-ray induced myocardial fibrosis.关键词：lncR-TUG1;Primary cilia;X-ray;Myocardial fibroblast;Myocardial fibrosis34|30|0更新时间：2025-08-21
- “在胰腺癌治疗领域，河北医科大学第一医院专家对比了M6型射波刀多叶准直器和固定准直器的剂量学特性，为临床决策提供个体化选择方案。”摘要：To investigate the dosimetric characteristics of the M6 CyberKnife multileaf collimator (MLC) and fixed collimator (FC) in pancreatic cancer treatment plans, a retrospective analysis was conducted on 44 patients treated with the CyberKnife at the First Hospital of Hebei Medical University from May 2021 to April 2023, with both MLC and FC plans being created for comparison.The evaluation focused on several parameters, including target coverage, conformity index (CI), new conformity index (nCI), treatment time, and monitor units (MU). In the small volume group (≤60 cm³), the MLC plan demonstrated significant advantages over the FC plan in treatment time and MU. Within the large volume group (>60 cm³), the FC plan showed remarkable superiority in target coverage ((90.43±5.07)% vs. (87.59±6.14)%, p<0.001). Its CI (1.09±0.03 vs. 1.23±0.13) and nCI (1.21±0.07 vs. 1.41±0.16, p<0.05) were also better than the MLC plan. Nevertheless, the MLC plan still outperformed the FC plan in treatment time and MU. After activating the Timereduce function, the MLC plan’s coverage increased significantly. However, in the large volume group, the FC plan continued to maintain better CI (1.10±0.07) and nCI (1.29±0.12, p>0.05). In clinical practice, the choice of collimator type should be based on target volume, patient tolerance, and treatment requirements. For small pancreatic cancer targets, the MLC plan is more efficient in terms of treatment time and MU. For larger targets, while the FC plan offers better coverage and conformity, it requires longer treatment times.关键词：Pancreatic cancer;CyberKnife;Fixed collimator;Multileaf collimator;Dosimetry31|43|0更新时间：2025-08-21
RADIOBIOLOGY AND RADIOMEDICINE
- “国内辐照加工行业面临质量控制难题，本研究提出基于边缘云协同技术的质量提升方法，为辐照行业高质量发展提供技术支撑。”摘要：The domestic irradiation processing industry faces the challenge that traditional quality control methods cannot meet the actual demands of irradiation processing. This study proposes a quality improvement method based on edge cloud collaborative technology. Specifically, it analyzes the characteristics of multi-dimensional real-time data such as source intensity, conveyor belt speed, temperature, and humidity during the irradiation processing, and constructs an edge cloud collaborative processing architecture. This system enables real-time monitoring of irradiation products at the edge and deep analysis and feedback at the cloud end for collaborative optimization. The key components include: 1) Designing a terminal data collection scheme using the OPC UA protocol to unify data transmission across heterogeneous devices; 2) Designing a convolutional autoencoder network model to perform dimensionality reduction at the edge and reconstruction at the cloud for multi-dimensional data, reducing transmission load while preserving key features; 3) Establishing a dose-process parameter mapping model at the cloud end to perform deep analysis of cloud data and provide dynamic feedback for optimizing the processing strategy. The results show that this method can control dose accuracy fluctuations within 6%, improving the product qualification rate to 95%. The constructed lightweight management platform enables process monitoring and quality control, providing technical support for the high-quality development of the irradiation industry.关键词：Irradiation processing;Edge cloud;Collaborative technology;Quality improvement54|126|0更新时间：2025-08-21
- “在食品科学领域，研究人员采用60Co γ辐照和丁酸梭菌发酵技术处理克氏原鳌虾副产物，显著提高了其营养价值。”摘要：The by-products of Procambarus clarkii were treated using methods such as 60Co γ-ray irradiation and Clostridium butyricum fermentation. The effects of different absorbed doses on the sterilization and degradation of macromolecules, such as crude protein and crude fat, in the by-products were studied. Additionally, the impact of different amounts of Procambarus clarkii by-products on strain growth, and the production of butyric acid and acetic acid, as well as the synergistic effects of irradiation and fermentation on the by-products, were also investigated. The results showed that a dose of 8.23 kGy effectively killed spoilage and pathogenic microorganisms in the by-products. The content of amino acids, total nutrients, oligopeptides, and other substances in the irradiated samples was significantly higher than that in the control group (p < 0.05). When the glucose concentration was 25 g/L and the concentration of Procambarus clarkii by-products was 30 g/L, the growth performance of Clostridium butyricum was optimal, producing 3.25 g/L butyric acid and 1.64 g/L acetic acid. The irradiation-assisted fermentation of Procambarus clarkii by-products by Clostridium butyricum resulted in significantly better outcomes compared to non-irradiated fermentation treatments. Compared to the control, the amino acid content increased by 41.28%, the total nutrient content increased by 106.08%, and the oligopeptide content increased by 194.16%. Therefore, the synergistic treatment of irradiation and fermentation enhances the nutritional value of Procambarus clarkii by-products.关键词：Procambarus clarkii;Byproducts;Irradiation;Clostridium butyricum38|33|0更新时间：2025-08-21
RADIATION TECHNOLOGY APPLICATION
- “在5G技术领域，专家基于电磁剂量学原理建立标准人体模型，计算5G基站天线对人体电磁暴露水平，结果低于国际限值，不会对公众健康构成威胁。”摘要：As 5G technology advances, the large-scale deployment of 5G base stations has led to an increase in electromagnetic radiation intensity in the environment, which may pose a potential threat to public health. This study, based on the principles of electromagnetic dosimetry, establishes a standard human body model and calculates the dielectric parameters of human tissues using the four-order-Cole-Cole model. Using the HFSS module in Ansys Electronics Desktop software, a 5G base station antenna array was designed, and the electromagnetic exposure levels to the human body at different positions were calculated. The results show that, in the main radiation direction, the maximum local SAR for the human torso is 1.53×10⁻³ W/kg, the maximum local SAR for the head is 0.020 9 W/kg, and the maximum incident power density is 0.007 13 W/m². In the edge radiation direction, the maximum local SAR for the human torso is 2.24×10⁻⁵ W/kg, the maximum local SAR for the head is 9.49×10⁻⁴ W/kg, and the maximum incident power density is 9.49×10⁻⁴ W/m². All results are below the public exposure limits set by the International Commission on Non-Ionizing Radiation Protection (ICNIRP), indicating that the electromagnetic exposure levels produced by the base station antenna do not pose a threat to public health.关键词：5G;Base station antenna;Electromagnetic radiation;Specific absorption rate65|176|0更新时间：2025-08-21
- “在核电技术领域，专家设计了适用于海洋岛屿的自动放射性监测系统，为海上核电设施辐射环境监测提供解决方案。”摘要：With the continuous advancement of third-generation nuclear power technology, the application scenarios of small nuclear reactor platforms are expanding beyond coastal nuclear power plants. This paper designs an automatic radiological monitoring system for marine island scenarios to meet the radiation monitoring needs of nuclear power facilities in specialized application environments. The system aims to expand the scope of environmental radiation monitoring and enhance relevant standards. A typical island in the northern South China Sea was selected as the application scenario, and its meteorological and climatic conditions, as well as pollutant dispersion simulation results, were analyzed. Based on this analysis and drawing from the experience of terrestrial nuclear power environmental radiation monitoring systems, the design of the system includes components such as anti-rolling automatic weather stations, gamma monitoring station networks, unmanned mobile data acquisition systems, data communication networks, and environmental monitoring central stations. The system also utilizes domestic environmental dose detectors and microcontroller unit data acquisition systems, and the entire set of application software was developed independently. Continuous operation tests were conducted in a coastal area in South China. After 198 days of continuous operation, the system demonstrated stable performance with a data acquisition rate exceeding 99%. The monthly average of the 60-second average dose rate was around 100 nGy/h, consistent with normal background radiation levels. The meteorological data showed consistent trends when compared with the local meteorological bureau's standard weather station, proving to be reliable and stable. The test results demonstrate that the system can meet the radiation monitoring needs of nuclear power facilities in island environments and is stable, reliable, and suitable for specialized maritime environments.关键词：Island scenario;Nuclear power plant;Environmental radiation monitoring;Automatic radioactive monitoring system;Meteorological data61|77|0更新时间：2025-08-21
RADIATION PROTECTION
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