In this paper, the preparation influencing factors of PVA-PAAS-AM hydrogel wound dressings were investigated under electron accelerator irradiation. Physical and chemical properties were tested at the same time. This approach was designed to improve hydrogel wound dressings pipette ability in the body exudates environment. Poly acrylate sodium (PAAS) and polyvinyl alcohol (PVA) and AM (Acrylamide) were selected for this study by an orthogonal experimental design method, dissolved into a homogeneous aqueous solution at high temperature, and the new polymer hydrogel was synthesized by the electron accelerator radiation. Performance testing of the infrared spectra, the swelling degree and the tensile strength of hydrogel membrane were carried out. If we considered the hydrogel dressing by liquid absorbing capacity as criteria, the best ratio of PAAS, PVA and AM was 26: 2: 9, the degree of swelling in saline was (4,582.5±316.3)%. The triple-distilled water swelling degree in the series of the hydrogel membrane was up to (46850.8 ± 4256.7)%, the tensile strength was up to (2.677 ± 0.752) MPa. A salt tolerant hydrogel dressing was prepared by using a terpolymer. The capacity of the new type of PVA/PAAS/AM hydrogel dressing was superior to current products and this work laid a foundation for further clinical applications.Cited