Evaluating biocompatibility of goose head nail steel plat after sterilizing by irradiation was performed to explore and promote radiation sterilization in biomedical material. Initial bacteria contaminated in goose head nail, its recovery rate and corrected factor were determined according to the standard ISO111737 while the absorbed dose setting was completed based on the Method 2 in standard ISO11137. The blood compatibility and heat evaluation test was carried out after eligible radiation sterilization. The results indicate that neither genotoxicity nor heat source to induce the hemolysis was found in goose head nail steel plate after irradiation sterilization. It has been found that artificial joint has good blood compatibility after irradiation sterilization. It suggests that irradiation sterilization could be used as an effective sterilization method.