ZHANG Chao, WANG Jichao, CAI Jianming. Radiosensitive effects and relative mechanism of CpG oligodeoxynuleotide[J]. Journal of Radiation Research and Radiation Processing, 2011,29(5):257-260.
ZHANG Chao, WANG Jichao, CAI Jianming. Radiosensitive effects and relative mechanism of CpG oligodeoxynuleotide[J]. Journal of Radiation Research and Radiation Processing, 2011,29(5):257-260.DOI:
Synthetic oligodeoxynucleotides (ODN) containing unmethylated deoxycytosine deoxyguanosine (CpG) motifs bind to Toll-like receptor 9 (TLR9) and can stimulate both innate and adaptive immune reactions. Therefore, CpG-ODN shows high worth and broad application prospects in clinic of adjuvants, immunotherapy for tumor and allergic diseases. The effect and relative mechanism of radiosensitive effects with CpG-ODN is discussed in this paper.