LIU Qingjie, FENG Jiangbin, LU Xue. Advances in mitochondrial DNA and its applicative research in radiation biology[J]. Journal of Radiation Research and Radiation Processing, 2004,22(2):65-68.
LIU Qingjie, FENG Jiangbin, LU Xue. Advances in mitochondrial DNA and its applicative research in radiation biology[J]. Journal of Radiation Research and Radiation Processing, 2004,22(2):65-68.DOI:
Mitochondrial DNA (mtDNA) is the only genome outside cell nucleus. It is very sensitive to oxidative damages, such as radiation, because of absence of histone protection and lacking efficient DNA repair mechanism. The paper summarizes research progresses on mtDNA in the field of radiosensitivity, radiation dose-effect relationship, radiation-induced mutation and carcinogenesis in recent years. Prospective application of mtDNA in radiation biology is also outlined.