P44/42MAPK在辐射诱发会厌癌中的表达

傅志超; 程惠华; 蔡建明; 王凤玫; 韩玲; 陈建英

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P44/42MAPK在辐射诱发会厌癌中的表达

研究论文 | 更新时间：2023-03-30

- P44/42MAPK在辐射诱发会厌癌中的表达
- Function of P44/42 mitogen-activated protein kinases in epiglottis carcinoma induced by radiation
- 辐射研究与辐射工艺学报 2006年24卷第1期页码：31-33
- 作者机构：
  
  1.南京军区福州总医院放疗科　福州　350025
  2.第二军医大学放射医学教研室　上海　200433
- 作者简介：
  
  傅志超，男，1977年9月出生，2003年在第二军医大学获放射医学专业硕士学位，住院医师，主要从事肿瘤临床放射生物学研究
- 基金信息：
- DOI：
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傅志超, 程惠华, 蔡建明, 等. P44/42MAPK在辐射诱发会厌癌中的表达[J]. 辐射研究与辐射工艺学报, 2006,24(1):31-33.

FU Zhichao, CHEN Huihua, CAI Jianming, et al. Function of P44/42 mitogen-activated protein kinases in epiglottis carcinoma induced by radiation[J]. Journal of Radiation Research and Radiation Processing, 2006,24(1):31-33.
傅志超, 程惠华, 蔡建明, 等. P44/42MAPK在辐射诱发会厌癌中的表达[J]. 辐射研究与辐射工艺学报, 2006,24(1):31-33. DOI：

FU Zhichao, CHEN Huihua, CAI Jianming, et al. Function of P44/42 mitogen-activated protein kinases in epiglottis carcinoma induced by radiation[J]. Journal of Radiation Research and Radiation Processing, 2006,24(1):31-33. DOI：

摘要

探讨P44/42MAPK在X射线诱发会厌癌的表达及其作用。从X射线诱发的会厌癌中得到肿瘤组织及相应的癌旁正常组织，分离总蛋白及mRNA，应用蛋白印迹法分析两组P44/42MAPK的表达及磷酸化水平，应用逆转录-聚合酶链反应（Reverse transcription-polymerase chain reaction，RT−PCR）半定量方法得到两组P42MAPK的mRNA 变化。结果表明，会厌癌P44/42MAPK的蛋白表达及磷酸化水平均显著高于癌旁正常组织，P42MAPK的mRNA在会厌癌中的表达也明显升高。结果显示，P44/42MAPK在X射线诱发会厌癌有异常表达且磷酸化水平显著增高，此信号转导途径可能在X射线诱发会厌癌发挥一定的作用。

Abstract

The work is to investigate the role of the P44/42 mitogen-activated protein kinases in proliferation disorder of epiglottis carcinoma induced by X-ray irradiation. After obtaining the tissues from the radiation−induced epiglottis carcinoma, we observed the P44/42MAPK protein expression level and the phosphoryation level in epiglottis carcinoma by western blotting, and the mRNA level by semi-quantitative RT−PCR. The results showed that The P44/42MAPK expression of protein and mRNA was significantly higher in lepiglottis carcinoma than in normal tissue nearby the tumor. And the level of P44/42MAPK phosphoryation in epiglottis carcinoma was higher than in that of the normal tissue. The results suggest that P44/42MAPK may play a role in proliferation disorder of epiglottis carcinoma l induced by the radiation.

关键词

辐射致癌信号转导丝裂活化蛋白激酶会厌癌

Keywords

Signal transductionMitogenactivated Protein KinasesEpiglottis carcinomaRadiation carcinogenesis

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