As polyester polyethylene composite membrane/ polyethylene is a new type of biological material suitable for clinical uses, the products were conducted dosage setting for radiation sterilization in accordance with ISO111737 in order to certificate if they are safe after radiation sterilization by use of platelet adhesion performance test, Ames test and the micronucleus test referred to ISO10993. It has been confirmed that after radiation sterilization the material have no genetic toxicity (not cause chromosomal aberrations) and can not increase the incidence of the micronucleus of the bone marrow polychromatocytes cells though there is no carcinogenic effects. Radiation sterilization does not affect the stability of the polyester polyethylene composite membrane/polyethylene (coronary artery stents). It means that as a good method radiation sterilization is worth to promote.