Attempts were afforded to search for new antiaplastic anemia drays from tetrapyrroles. Observation of the effects of copper purpurin 18, a representative one of the metal tetrapyrroles was synthesized by ours, on erythropoiesis in Kungming mice lethally irradiated. It was shown that copper purpurin18 preferably increased stem cells (CFU-S) into erythroidpregenitor cells (CFU-E) ,and increase WBC and nucleated cells of bone marrow significantly in the phase of recover. It suggested that there may be good prospect in developing new drugs for treatment of aplastic anemia with copper purpurin 18,and it was worth to further investigations.