低剂量辐射诱导细胞激活过程中基因和蛋白分子的变化

刘树铮; 白欧; 陈东; 叶飞

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低剂量辐射诱导细胞激活过程中基因和蛋白分子的变化

研究论文 | 更新时间：2023-04-07

- 低剂量辐射诱导细胞激活过程中基因和蛋白分子的变化
- GENES AND PROTEIN MOLECULES INVOLVED IN THE CELLULAR ACTIVATION INDUCED BY LOW DOSE RADIATION^*
- Journal of Radiation Research and Radiation Processing 2000年18卷第3期页码：175-186
- 作者机构：
  
  1.白求恩医科大学放射生物教研室长春 130021
- 作者简介：
- 基金信息：
  
  the National Natural Science Foundation of China(39270202;39570188)
- DOI：
  中图分类号：
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刘树铮, 白欧, 陈东, 等. 低剂量辐射诱导细胞激活过程中基因和蛋白分子的变化[J]. Journal of Radiation Research and Radiation Processing, 2000,18(3):175-186.

LIU Shuzheng, BAI Ou, CHEN Dong, et al. GENES AND PROTEIN MOLECULES INVOLVED IN THE CELLULAR ACTIVATION INDUCED BY LOW DOSE RADIATION^*[J]. 辐射研究与辐射工艺学报, 2000,18(3):175-186.
刘树铮, 白欧, 陈东, 等. 低剂量辐射诱导细胞激活过程中基因和蛋白分子的变化[J]. Journal of Radiation Research and Radiation Processing, 2000,18(3):175-186. DOI：

LIU Shuzheng, BAI Ou, CHEN Dong, et al. GENES AND PROTEIN MOLECULES INVOLVED IN THE CELLULAR ACTIVATION INDUCED BY LOW DOSE RADIATION^*[J]. 辐射研究与辐射工艺学报, 2000,18(3):175-186. DOI：

摘要

本文报道全身X射线照射后小鼠胸腺和/或脾脏中与细胞存活及细胞周期调控相关基因转录和表达水平, 与免疫反应相关基因的转录水平以及信号分子表达的变化. 结果显示, 高、低剂量照射引起所检测的大多数参数的相反效应. 分析了这些变化在不同剂量电离辐射所致细胞反应发生中的意义.

Abstract

ABSTRACT The effect of whole-body X-irradiation on the transcription and expression level of genes related to cell survival and cell cycle control, the transcription level of genes related to immune responses as well as the signal molecules of mouse thymocytes and/or splenocytes was reviewed. Opposite effects from low versus high doses of irradiation were demonstrated in most of the parameters examined. The implications of these changes in connection with the cellular responses after different doses of ionizing radiation were analyzed.

关键词

辐射基因细胞存活细胞因子细胞周期调控信号传递

Keywords

KEYWORDS RadiationGenesCell survivalCytokinesCell cycle controlSignal transduction

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