小鼠小肠RNA对受<sup>60</sup>Co γ射线照射同系小鼠小肠损伤的恢复

曾桂英; 田芙蓉; 陈永斌; 任东青; 崔大祥

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小鼠小肠RNA对受⁶⁰Co γ射线照射同系小鼠小肠损伤的恢复

研究论文 | 更新时间：2023-04-07

- 小鼠小肠RNA对受⁶⁰Co γ射线照射同系小鼠小肠损伤的恢复
- THE RESTORATIVE EFFECT OF MOUSE INTESTINAL RNA ON THE SMALL INTESTINE OF MICE OF THE SAME STRAIN AFTER γ RAY IRRADIATION
- 辐射研究与辐射工艺学报 2001年19卷第1期页码：59-61
- 作者机构：
  
  1.第四军医大学放射医学教研室　西安　710032
  2.第四军医大学全军基因诊断技术研究所　西安　710032
- 作者简介：
  
  曾桂英，女，1945年12月出生，1970年毕业于华西医科大学，教授，放射生物学专业
- 基金信息：
- DOI：
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曾桂英, 田芙蓉, 陈永斌, 等. 小鼠小肠RNA对受⁶⁰Co γ射线照射同系小鼠小肠损伤的恢复[J]. 辐射研究与辐射工艺学报, 2001,19(1):59-61.

ZENG Guiying, TIAN Furong, CHEN Yongbin, et al. THE RESTORATIVE EFFECT OF MOUSE INTESTINAL RNA ON THE SMALL INTESTINE OF MICE OF THE SAME STRAIN AFTER γ RAY IRRADIATION[J]. Journal of Radiation Research and Radiation Processing, 2001,19(1):59-61.
曾桂英, 田芙蓉, 陈永斌, 等. 小鼠小肠RNA对受⁶⁰Co γ射线照射同系小鼠小肠损伤的恢复[J]. 辐射研究与辐射工艺学报, 2001,19(1):59-61. DOI：

ZENG Guiying, TIAN Furong, CHEN Yongbin, et al. THE RESTORATIVE EFFECT OF MOUSE INTESTINAL RNA ON THE SMALL INTESTINE OF MICE OF THE SAME STRAIN AFTER γ RAY IRRADIATION[J]. Journal of Radiation Research and Radiation Processing, 2001,19(1):59-61. DOI：

摘要

用不同剂量的,60,Co γ射线照射BALB/c小鼠的全身或腹部，于照射后1—3h内注入同系正常小鼠小肠RNA，通过肠腺存活率的测定，观察小肠RNA显效时间和照射方式对其修复作用的影响。结果表明，（1）小鼠受照射后6h空肠肠腺存活率即开始降低，4d时降至最低值；（2）受腹部照射小鼠在小肠RNA注入后6h肠腺存活率比照射对照组提高21.40%;（3）正常小鼠小肠RNA在促进受全身照射小鼠十二指肠、空肠和回肠恢复时的DMF（Dose Modifying Factor）分别为1.17、1.12、1.10。结果说明，小肠RNA不仅可提高受腹部照射同系小鼠空肠肠腺存活率，而且也可提高受全身照射同系小鼠十二指肠、空肠和回肠的肠腺存活率，并在注入后6h即可表现出来。

Abstract

Mouse intestinal RNA was injected into the mice of the same strain within 1—3h after different doses of abdominal or whole body ,60,Co ,γ, irradiation,so as to explore the initial effective time of mouse intestinal RNA and the affection of radiation condition on its restorative effect, by measuring the survival of mouse intestinal crypt. The results showed (1) A decrease in the survival of mouse intestinal crypt began 6h after the irradiation,and the lowest survival rate appeared on the fourth day.(2) The survival of mouse intestinal crypt of the abdominal irradiated mice increased 21.4% at 6h after intestinal RNA injection as compared with that of the irradiated control group.(3) The dose modifying factor (DMF) of normal mouse intestinal RNA in the promotion of the recovery of the duodenum, jejunum and ileum of mice after whde body irradiation 1.17, 1.12 and 1.10 respectively. The above results suggest that mouse intestinal RNA can raise not only the survival of jejunum crypt of the mice of the same strain after abdominal irradiation but also the survival of crypt of the duodenum, jejunum and ileum of the mouse after whole body irradiation, which may be observed 6h after the irradiation.

关键词

小肠RNAγ射线小鼠肠腺存活率

Keywords

Intestinal RNAγ rayMouseSurvuval of mouse crypt

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小鼠小肠RNA对受60Co γ射线照射同系小鼠小肠损伤的恢复

THE RESTORATIVE EFFECT OF MOUSE INTESTINAL RNA ON THE SMALL INTESTINE OF MICE OF THE SAME STRAIN AFTER γ RAY IRRADIATION

DOI：

摘要

Abstract

关键词

Keywords

references

小鼠小肠RNA对受⁶⁰Co γ射线照射同系小鼠小肠损伤的恢复