高能电子线辐射损伤对TGF-β<sub>1</sub>表达及Ⅰ、Ⅲ型胶原含量的影响

周迎会; 徐岚; 吴士良; 史宁; 涂友斌; 彭淼

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高能电子线辐射损伤对TGF-β₁表达及Ⅰ、Ⅲ型胶原含量的影响

综述 | 更新时间：2023-04-07

- 高能电子线辐射损伤对TGF-β₁表达及Ⅰ、Ⅲ型胶原含量的影响
- THE INFLUENCE ON THE EXPRESSION OF TGF-β₁ AND THE CONTENTS OF COLLAGEN TYPE I AND TYPE III BY HIGH ENERGY ELECTRONS RADIATION INJURY
- 辐射研究与辐射工艺学报 2002年20卷第1期页码：67-71
- 作者机构：
  
  1.苏州大学生物化学及分子生物学教研室　苏州　215007
- 作者简介：
  
  周迎会，女，1965年出生，1985年毕业于南京师范大学，免疫学专业，副教授，硕士
  吴士良
- 基金信息：
  
  国家科工委国防预研基金课题(Y6920026—04)
- DOI：
  中图分类号：
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周迎会, 徐岚, 吴士良, 等. 高能电子线辐射损伤对TGF-β₁表达及Ⅰ、Ⅲ型胶原含量的影响[J]. 辐射研究与辐射工艺学报, 2002,20(1):67-71.

ZHOU Yinghui, XU Lan, WU Shiliang, et al. THE INFLUENCE ON THE EXPRESSION OF TGF-β₁ AND THE CONTENTS OF COLLAGEN TYPE I AND TYPE III BY HIGH ENERGY ELECTRONS RADIATION INJURY[J]. Journal of Radiation Research and Radiation Processing, 2002,20(1):67-71.
周迎会, 徐岚, 吴士良, 等. 高能电子线辐射损伤对TGF-β₁表达及Ⅰ、Ⅲ型胶原含量的影响[J]. 辐射研究与辐射工艺学报, 2002,20(1):67-71. DOI：

ZHOU Yinghui, XU Lan, WU Shiliang, et al. THE INFLUENCE ON THE EXPRESSION OF TGF-β₁ AND THE CONTENTS OF COLLAGEN TYPE I AND TYPE III BY HIGH ENERGY ELECTRONS RADIATION INJURY[J]. Journal of Radiation Research and Radiation Processing, 2002,20(1):67-71. DOI：

摘要

探讨了高能电子线辐射损伤后Ⅰ、Ⅲ型胶原含量的改变情况及TGF—β,1,对其的调控作用。采用电子直线加速器照射制作动物的辐射损伤模型，对NIH 3T3细胞进行照射，观察胶原总量及Ⅰ、Ⅲ型胶原含量的改变；测定损伤后细胞因子TGF—β,1,表达的变化情况。结果显示，损伤后胶原总量变化不大，而Ⅰ型胶原含量下降，Ⅲ型胶原含量上升；损伤后TGF—β,1,表达量增加。结果提示，放射性皮肤损伤引起了胶原代谢的变化，损伤后胶原代谢的调控机制中，TGF—β,1,可能起重要作用。

Abstract

To investigate the change of collagen type I and type III and the action of TGF-β,1, after high energy electrons radiation. The animal model of radiation injury was established by high energy electrons radiation produced by the linear accelerator; and irradiated NIH 3T3 cells were studied. In the experiment the contents of total collagen,collagen type Ⅰ and type III were measured. The contents of TGF—β,1, were also detected. The results showed after radiation,little change was found in the content of total collagen,but the content of collagen I decreased and the content of collagen III increased; the expression of TGF-β,1, increased. Changes in the collagen metabolism were caused by the irradiated injury of the skin; TGF—β,1, may be essential in the regulation of the collagen metabolism.

关键词

电子辐射损伤胶原TGF—β1

Keywords

ElectronRadiation injuryCollagenTGF-β1

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高能电子线辐射损伤对TGF-β1表达及Ⅰ、Ⅲ型胶原含量的影响

THE INFLUENCE ON THE EXPRESSION OF TGF-β1 AND THE CONTENTS OF COLLAGEN TYPE I AND TYPE III BY HIGH ENERGY ELECTRONS RADIATION INJURY

DOI：

摘要

Abstract

关键词

Keywords

references

高能电子线辐射损伤对TGF-β₁表达及Ⅰ、Ⅲ型胶原含量的影响

THE INFLUENCE ON THE EXPRESSION OF TGF-β₁ AND THE CONTENTS OF COLLAGEN TYPE I AND TYPE III BY HIGH ENERGY ELECTRONS RADIATION INJURY