腹腔注射α核素<sup>211</sup>At对小鼠睾丸生殖细胞的辐射损伤及LD<sub>50</sub>测定

刘宁; 金建南; 夏庆杰; 张叔渊

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腹腔注射α核素²¹¹At对小鼠睾丸生殖细胞的辐射损伤及LD₅₀测定

更新时间：2023-04-18

- 腹腔注射α核素²¹¹At对小鼠睾丸生殖细胞的辐射损伤及LD₅₀测定
- RADIOTOXICITY OF α-EMITTER ²¹¹At FOR TESTES AND ITS LD₅₀ IN MICE
- 辐射研究与辐射工艺学报 1998年16卷第2期页码：102-105
- 作者机构：
  
  1.四川大学原子核科学技术研究所　辐射物理及技术国家教委开放实验室　成都　610064
- 作者简介：
- 基金信息：
  
  国家教委博士学科点基金资助课题
- DOI：
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刘宁, 金建南, 夏庆杰, 等. 腹腔注射α核素²¹¹At对小鼠睾丸生殖细胞的辐射损伤及LD₅₀测定[J]. 辐射研究与辐射工艺学报, 1998,16(2):102-105.

Liu Ning, Jin Jiannan, Xia Qingjie, et al. RADIOTOXICITY OF α-EMITTER ²¹¹At FOR TESTES AND ITS LD₅₀ IN MICE[J]. Journal of Radiation Research and Radiation Processing, 1998,16(2):102-105.
刘宁, 金建南, 夏庆杰, 等. 腹腔注射α核素²¹¹At对小鼠睾丸生殖细胞的辐射损伤及LD₅₀测定[J]. 辐射研究与辐射工艺学报, 1998,16(2):102-105. DOI：

Liu Ning, Jin Jiannan, Xia Qingjie, et al. RADIOTOXICITY OF α-EMITTER ²¹¹At FOR TESTES AND ITS LD₅₀ IN MICE[J]. Journal of Radiation Research and Radiation Processing, 1998,16(2):102-105. DOI：

摘要

研究了单次腹腔注射离子型Na ,211,At对NIH小白鼠睾丸生殖细胞辐射损伤的影响，并测定了Na ,211,At对NIH小鼠的LD,50,/7。结果表明：注射5.55×10,5,Bq的,211,At在30d内可使精子耗竭。,211,At电离辐射能够显著降低睾丸的质量，对生殖细胞和支持细胞有明显的辐射损伤作用。采用点斜法计算得,211,At对小鼠的半致死剂量LD,50,/7为8.14×10,4,Bq/g。

Abstract

The radiotoxicity of α-emitter ,211,At for testes in NIH strain mice was investigated by a singular i.p. injection with 5.55×10,5, Bq of Na ,211,At, and the histopathological change of testicular cells was observed. Testes mass decreased rapidly at 6~30 days post-injection. Histopathological observation revealed that some cells of interstitial tissue are irradiated to death at 6 days, the semininferous tubules become empty at 30 days post-injection, and there is no spermatogenesis any more at this time. Additionally, the lethal dose (LD,50,) of ,211,At in the mice was investigated also by i.p injection and a LD,50,/7 of 8.14×10,4,Bq/g was measured.

关键词

211At小鼠睾丸辐射损伤LD50

Keywords

211AtMiceTestisRadiotoxicityLD50

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腹腔注射α核素211At对小鼠睾丸生殖细胞的辐射损伤及LD50测定

RADIOTOXICITY OF α-EMITTER 211At FOR TESTES AND ITS LD50 IN MICE

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摘要

Abstract

关键词

Keywords

references

腹腔注射α核素²¹¹At对小鼠睾丸生殖细胞的辐射损伤及LD₅₀测定

RADIOTOXICITY OF α-EMITTER ²¹¹At FOR TESTES AND ITS LD₅₀ IN MICE