马蔺子甲素对<italic style="font-style: italic">γ</italic>线照射的S-180 V肿瘤细胞DNA单链断裂重接的抑制作用

章扬培; 范国才; 夏寿萱

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马蔺子甲素对γ线照射的S-180 V肿瘤细胞DNA单链断裂重接的抑制作用

研究论文及科研成果报告 | 更新时间：2023-04-23

- 马蔺子甲素对γ线照射的S-180 V肿瘤细胞DNA单链断裂重接的抑制作用
- THE INHIBITION OF γ-RAY INDUCED DNA SINGLE STRAND BREAK REJOINING IN S-180V TUMOR CELLS BY RADIOSENSITIZER IRISQUINONE
- 辐射研究与辐射工艺学报 1985年3卷第4期页码：39-42
- 作者机构：
  
  1.军事医学科学院放射医学研究所
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章扬培, 范国才, 夏寿萱. 马蔺子甲素对γ线照射的S-180 V肿瘤细胞DNA单链断裂重接的抑制作用[J]. 辐射研究与辐射工艺学报, 1985,3(4):39-42.

Zhang Yangpei, Fan Guocai, Xia Shouxuan. THE INHIBITION OF γ-RAY INDUCED DNA SINGLE STRAND BREAK REJOINING IN S-180V TUMOR CELLS BY RADIOSENSITIZER IRISQUINONE[J]. Journal of Radiation Research and Radiation Processing, 1985,3(4):39-42.
章扬培, 范国才, 夏寿萱. 马蔺子甲素对γ线照射的S-180 V肿瘤细胞DNA单链断裂重接的抑制作用[J]. 辐射研究与辐射工艺学报, 1985,3(4):39-42. DOI：

Zhang Yangpei, Fan Guocai, Xia Shouxuan. THE INHIBITION OF γ-RAY INDUCED DNA SINGLE STRAND BREAK REJOINING IN S-180V TUMOR CELLS BY RADIOSENSITIZER IRISQUINONE[J]. Journal of Radiation Research and Radiation Processing, 1985,3(4):39-42. DOI：

摘要

本文应用碱洗脱法观察了中草药马蔺子甲素对S-180V细胞DNA损伤与修复的影响，观察到马蔺子甲素能作用于辐射敏感的靶分子DNA，抑制DNA的正常合成和链断裂后的重接修复，从而表现出放射增敏作用。在本实验条件下，马蔺子甲素在有氧和乏氧时的作用无差别。

Abstract

It is reported that Irisquinone, an active component from Chinese herb Iris pallasii Fischer, could modify the radiosensitivity of the tumor cells in cancer radiotherapy. By means of alkaline elution method modified in our laboratory, the effect of Irisquinone on γ-ray induced DNA single strand breaks and their rejoining in S-180V cells was studied. The results showed that this compound could inhibit both the processes of normal DNA synthesis and the rejoining of DNA single strand breaks. There was no significant difference between the effects under aerobic and hypoxic conditions.

关键词

DNA损伤与修复DNA链断裂辐射增敏剂肿瘤细胞

Keywords

DNA damageDNA repairDNA strand breakradiosensitizertumor cells

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马蔺子甲素对γ线照射的S-180 V肿瘤细胞DNA单链断裂重接的抑制作用

THE INHIBITION OF γ-RAY INDUCED DNA SINGLE STRAND BREAK REJOINING IN S-180V TUMOR CELLS BY RADIOSENSITIZER IRISQUINONE

DOI：

摘要

Abstract

关键词

Keywords

references