<sup>60</sup>Co-γ线照射后小鼠T、B淋巴细胞DNA合成、单链断裂、修复能力的比较研究

殷建林; 苏燎原; 刘克良

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⁶⁰Co-γ线照射后小鼠T、B淋巴细胞DNA合成、单链断裂、修复能力的比较研究

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- ⁶⁰Co-γ线照射后小鼠T、B淋巴细胞DNA合成、单链断裂、修复能力的比较研究
- COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER ⁶⁰Co GAMMA-RAYS IRRADIATION
- 辐射研究与辐射工艺学报 1988年6卷第1期页码：33-37
- 作者机构：
  
  1.苏州医学院，苏州
- 作者简介：
- 基金信息：
  
  国家自然科学基金会资助的课题
- DOI：
  中图分类号：
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殷建林, 苏燎原, 刘克良. ⁶⁰Co-γ线照射后小鼠T、B淋巴细胞DNA合成、单链断裂、修复能力的比较研究[J]. 辐射研究与辐射工艺学报, 1988,6(1):33-37.

Yin Jianlin, Su Liaoyuan, Liu Keliand. COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER ⁶⁰Co GAMMA-RAYS IRRADIATION[J]. Journal of Radiation Research and Radiation Processing, 1988,6(1):33-37.
殷建林, 苏燎原, 刘克良. ⁶⁰Co-γ线照射后小鼠T、B淋巴细胞DNA合成、单链断裂、修复能力的比较研究[J]. 辐射研究与辐射工艺学报, 1988,6(1):33-37. DOI：

Yin Jianlin, Su Liaoyuan, Liu Keliand. COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER ⁶⁰Co GAMMA-RAYS IRRADIATION[J]. Journal of Radiation Research and Radiation Processing, 1988,6(1):33-37. DOI：

摘要

本文采用滤膜法和碱洗脱法比较研究了γ线照射后T、B淋巴细胞DNA合成、ssb（单链断裂）及修复能力。B淋巴细胞DNA合成明显低于T淋巴细胞；虽两种细胞产生DNA ssb没有差别，但其修复能力，T淋巴细胞高于B淋巴细胞。说明在分子水平上，B淋巴细胞辐射敏感性高于T淋巴细胞；DNA ssb的修复能力与DNA合成可能存在一定的联系。

Abstract

The synthesis of DNA in T, B lymphocytes was investigated by the determination of ,3,H-TdR incorporation after Gamma-irradiation. The DNA ssb (single strand breaks) and repair in lymphocytes were measured by alkaline elution. The DNA synthesis in B lymphocytes was much lower than that in T lymphocytes. No significant difference in DNA ssb was found between T and B lymphocytes, but a less efficient process of repair was observed in B lymphocytes, So it was conceived that B lymphocytes were more sensitive to Gamma-irradiation than T lymphocytes and DNA synthesis might be related with the repair of DNA ssb.

关键词

DNA合成DNA ssbDNA修复T、B淋巴细胞辐射敏感性碱洗脱法

Keywords

DNA synthesisDNA ssbDNA repairT lymphocytesB lymphocytesRadiosensitivityAlkaline elution

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60Co-γ线照射后小鼠T、B淋巴细胞DNA合成、单链断裂、修复能力的比较研究

COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER 60Co GAMMA-RAYS IRRADIATION

DOI：

摘要

Abstract

关键词

Keywords

references

⁶⁰Co-γ线照射后小鼠T、B淋巴细胞DNA合成、单链断裂、修复能力的比较研究

COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER ⁶⁰Co GAMMA-RAYS IRRADIATION