小剂量照射的淋巴细胞外液诱导其亚群细胞DNA合成的适应性反应

孔向蓉; 苏燎原; 刘永彪; 赵雨杰

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小剂量照射的淋巴细胞外液诱导其亚群细胞DNA合成的适应性反应

研究论文 | 更新时间：2023-04-23

- 小剂量照射的淋巴细胞外液诱导其亚群细胞DNA合成的适应性反应
- ADAPTIVE RESPONSE OF LYMPHOCYTE SUBSETS TO LOW DOSE γ-RADIATION ON DNA SYNTHESIS
- 辐射研究与辐射工艺学报 1997年15卷第2期页码：114-118
- 作者机构：
  
  1.苏州医学院放射医学系　苏州　215007
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孔向蓉, 苏燎原, 刘永彪, 等. 小剂量照射的淋巴细胞外液诱导其亚群细胞DNA合成的适应性反应[J]. 辐射研究与辐射工艺学报, 1997,15(2):114-118.

Kong Xiangrong, Su Liaoyuan, Liu Yongbiao, et al. ADAPTIVE RESPONSE OF LYMPHOCYTE SUBSETS TO LOW DOSE γ-RADIATION ON DNA SYNTHESIS[J]. Journal of Radiation Research and Radiation Processing, 1997,15(2):114-118.
孔向蓉, 苏燎原, 刘永彪, 等. 小剂量照射的淋巴细胞外液诱导其亚群细胞DNA合成的适应性反应[J]. 辐射研究与辐射工艺学报, 1997,15(2):114-118. DOI：

Kong Xiangrong, Su Liaoyuan, Liu Yongbiao, et al. ADAPTIVE RESPONSE OF LYMPHOCYTE SUBSETS TO LOW DOSE γ-RADIATION ON DNA SYNTHESIS[J]. Journal of Radiation Research and Radiation Processing, 1997,15(2):114-118. DOI：

摘要

预先给予4.0cGy γ射线照射的人外周血淋巴细胞，经PHA刺激24h后提取细胞外液，观察其对大剂量照射后受损伤的亚群细胞的影响。结果表明，CD,8,+,、CD,4,+,细胞损伤明显减轻，且损伤剂量分别为1.5、3.0Gy时，适应性反应最强。结果还显示，CD,8,+,细胞较CD,4,+,细胞对辐射更为敏感，且在1.5Gy剂量点附近，适应性反应亦更强。

Abstract

The extracellular fluid was extracted from human peripheral blood lymphocytes cultured with PHA for 24 hours after 4cGy irradiation. The effects of subsequent higher radiation doses on lymphocyte subsets were studied by intermixing the extracellular fluid. The resultshowed that the radiation damage of CD,8,+, and CD,4,+, were decreasedsignificantly,and the strongest adaptive response occourred at the dose of 1.5Gy and 3.0Gy separately. It also found that CD,8,+, cells was more radiosensitive thanCD,4,+, cells and the adaptive response of CD,8,+, was more obvious than that of CD,4,+, at the dose of 1.5Gy.

关键词

小剂量辐射细胞外液淋巴细胞亚群适应性反应

Keywords

Low dose irradiationExtracellular fluidLymphocyte subsetsAdaptive response

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