Wei Daoyan, Jin Aoxing, Huang Guo, et al. MECHANISM OF LOW DOSE X-RADIATION INFLUENCING B16 MELANOMA BLOOD-BORNE PULMONARY METASTASES[J]. Journal of Radiation Research and Radiation Processing, 1996,14(2):101-103.
Wei Daoyan, Jin Aoxing, Huang Guo, et al. MECHANISM OF LOW DOSE X-RADIATION INFLUENCING B16 MELANOMA BLOOD-BORNE PULMONARY METASTASES[J]. Journal of Radiation Research and Radiation Processing, 1996,14(2):101-103.DOI:
C 57 BL/6小鼠经7.5 cGy X线全身照射后24 h静脉注射,125,IUdR标记的B 16黑色素瘤细胞,24 h后测定肺活瘤细胞存留率时发现,照射组小鼠的肺活瘤细胞存留率明显降低。与此同时,于照射后24 h检测小鼠的免疫功能发现,照射组小鼠脾脏有核细胞数明显增多,脾细胞NK细胞毒活性及体内巨噬细胞功能均显著增强。结果提示,小剂量辐射可能通过提高NK细胞、巨噬细胞功能而加速肺内瘤细胞的清除速率。
Abstract
After whole body exposed to 7.5 cGy X-ray, the C57 BL/6 mice were I. V. injected with ,125,IUdR labelled B16 melanoma cells, the proportion of surviving labelled cells retained in lungs was detected at 24 hours after injection,and found that the surviving cells in the lungs of irradiated mice were significantly decreased. Meanwhile, the immunofunctions were tested at 24 hours after irradiation, the results showed that the number of nucleate cells and NK cytotoxity in spleens, and the phagocytotic function of macrophages in vivo were increased obviously for the irradiated mice. The results suggested that the enhancement of NK cytotoxity and macrophage phagocytotic function might be one of the important reasons for low dose radiation accelerating the clearance of tumor cells from the lungs.