生长因子TGF β 3对小鼠小肠隐窝细胞增殖的抑制

张宇光; C. S. Potten; C. Chadwick; D. Hewitt

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生长因子TGF β 3对小鼠小肠隐窝细胞增殖的抑制

研究论文 | 更新时间：2023-04-26

- 生长因子TGF β 3对小鼠小肠隐窝细胞增殖的抑制
- TH E EFFECTIVE OF PROLIFERATION IN THE SMALL INTESTINAL CRYPTS OF THE MOUSE FOLLOWING IN VIVO ADMINISTRATION OF GROWTH FACTOR TGFβ 3
- 辐射研究与辐射工艺学报 1996年14卷第2期页码：116-120
- 作者机构：
  
  1.中国医学科学院中国协和医科大学放射医学研究所，天津 300192
  2.Paterson Institute for Cancer Research, England
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张宇光, C. S. Potten, C. Chadwick, 等. 生长因子TGF β 3对小鼠小肠隐窝细胞增殖的抑制[J]. 辐射研究与辐射工艺学报, 1996,14(2):116-120.

Zhang Yuguang, C. S. Potten, C. Chadwick, et al. TH E EFFECTIVE OF PROLIFERATION IN THE SMALL INTESTINAL CRYPTS OF THE MOUSE FOLLOWING IN VIVO ADMINISTRATION OF GROWTH FACTOR TGFβ 3[J]. Journal of Radiation Research and Radiation Processing, 1996,14(2):116-120.
张宇光, C. S. Potten, C. Chadwick, 等. 生长因子TGF β 3对小鼠小肠隐窝细胞增殖的抑制[J]. 辐射研究与辐射工艺学报, 1996,14(2):116-120. DOI：

Zhang Yuguang, C. S. Potten, C. Chadwick, et al. TH E EFFECTIVE OF PROLIFERATION IN THE SMALL INTESTINAL CRYPTS OF THE MOUSE FOLLOWING IN VIVO ADMINISTRATION OF GROWTH FACTOR TGFβ 3[J]. Journal of Radiation Research and Radiation Processing, 1996,14(2):116-120. DOI：

摘要

转移生长因子TGF β 3是一种多功能调节剂，不同的给药剂量、给药次数及其间隔时间以及给药后的测定时间等均影响它对细胞增殖调控的能力。当重复给予TGF β 3,它对正常小鼠及8 Gy γ射线全身照射小鼠小肠隐窝底部的上皮细胞的增殖均起抑制作用，且随着给药次数的增多，TGF β 3对肠隐窝干细胞的抑制作用逐渐增强，提示它是干细胞生长的负调节因子。

Abstract

Transforming growth factor β 3 (TGF β 3) is a multifunctional regulator of cell growth. In epithelial tissue TGF β 3 was found to be a negative regulator of growth, it inhibits the proliferation in the small intestinal crypts of the mouse following in vivo administration. Various doses and dosing regimens were tested, TGF β 3 was an effective inhibitor of proliferation in unirradiated and after irradiated 18 hours recipients in all multiple doses cases, TGF β 3 tended to have its strongest inhibitory effects in the lower regions of the crypt.

关键词

小肠隐窝细胞增殖TGF β 3

Keywords

Intestinal cryptCell proliferationTGF β 3

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