碱性条件亚硝基自由基氧化鸟嘌呤和鸟苷

张周恩; 姚思德; 金一尊; 王文锋; 林维真; 钱素平; 林念芸

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碱性条件亚硝基自由基氧化鸟嘌呤和鸟苷

研究简报 | 更新时间：2023-04-26

- 碱性条件亚硝基自由基氧化鸟嘌呤和鸟苷
- OXIDATION OF GUANINE AND GUANOSINE BY RADICAL AT BASIC pH
- Journal of Radiation Research and Radiation Processing 2001年19卷第2期页码：148-152
- 作者机构：
  
  1.复旦大学放射医学研究所上海 200032
  2.中国科学院上海原子核研究所辐射化学开放实验室上海 201800
- 作者简介：
- 基金信息：
  
  国家自然科学基金(99QA14034)
- DOI：
  中图分类号：
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张周恩, 姚思德, 金一尊, 等. 碱性条件亚硝基自由基氧化鸟嘌呤和鸟苷[J]. Journal of Radiation Research and Radiation Processing, 2001,19(2):148-152.

ZHANG Zhouen, YAO Side, JIN Yizun, et al. OXIDATION OF GUANINE AND GUANOSINE BY RADICAL AT BASIC pH[J]. 辐射研究与辐射工艺学报, 2001,19(2):148-152.
张周恩, 姚思德, 金一尊, 等. 碱性条件亚硝基自由基氧化鸟嘌呤和鸟苷[J]. Journal of Radiation Research and Radiation Processing, 2001,19(2):148-152. DOI：

ZHANG Zhouen, YAO Side, JIN Yizun, et al. OXIDATION OF GUANINE AND GUANOSINE BY RADICAL AT BASIC pH[J]. 辐射研究与辐射工艺学报, 2001,19(2):148-152. DOI：

摘要

亚硝酸和,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767972&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767974&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767973&type=,自由基被证明为致DNA突变因子, 作为公认的氮原子中心的强氧化性亚硝基自由基,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767975&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767977&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767976&type=,对DNA的作用引起为数众多的科学家的关注, 但未观察到其直接作用的结果. 利用脉冲辐解技术在碱性条件下观察到,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767978&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767980&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767979&type=,直接氧化鸟嘌呤阴离子和鸟苷阴离子, 并测定pH12条件下,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767981&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767983&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767982&type=,氧化鸟嘌呤阴离子反应的速率常数k=1.3×10,8,dm,3,mol,-1,s,-1,. 但未观测到,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767984&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767952&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767985&type=,与脱氧鸟苷—5—磷酸及DNA的基他碱基的反应, 说明,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767986&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767988&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767987&type=,选择性氧化鸟嘌呤, 糖基和磷酸根及其组成的链具有保护DNA不被,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767989&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767991&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767990&type=,. 氧化的作用.

Abstract

Nitrogen doxide radical （,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767922&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767939&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767938&type=,） is known as a nitrogen centered free radical with powerful oxidizing properties. While ntric oxide and nitrous acid were prved to the able to cause mutation of DNA, the affect of ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767940&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767956&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767955&type=, radical to DNA has being concerned by many scientists, but its direct result has not been observed. In this work, the reaction of ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767957&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767960&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767959&type=, radical oxidizing guanine and guanosine in basic aqueous solution was observed directly by appoication of pulse radiolysis technique. Moreover,the rate constant of the reaction of ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767961&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767965&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767963&type=, radical oxidizing guanine at pH 12, has been measured bo be ,k,=1.3×10,8,. But to reaction about ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767967&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767946&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767969&type=, radical with deoxyguanosine 5'—phosphate of other DNA bases was detected. It means that ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767970&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767950&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42767948&type=, radical is a selective radical to oxidize guaine, and that the glucoside, phosphate and their link of DNA take the protective action against oxidation by nitrogen dioxide radical

关键词

亚硝基自由基鸟嘌呤鸟苷脉冲辐解

Keywords

Nitrogen dioxide radicalGuanineGuanosinePulse radiolysis

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