The aim is to find out the key proteins related with low dose radiation (LDR) by proteomic technology, which provided the theory foundation for LDR protection. Two-dimensional electrophoresis (2-DE) was performed on serum protein. Differential expression proteins were identified by matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) and database analysis. Compared with the control group, 7 altered proteins was definite in terms of apolipoprotein C-III, beta-globin, parotid secretory protein, alpha-2-macroglobulin precursor, mouse transthyretin, C1qc protein and clusterin. Some proteins related with LDR are found. It may provide some new explanations for the mechanism of LDR.Cited