A total of 170 lung cancer patients, who diagnosed with inoperable lung cancer and received radiotherapy, were included in the present study. DNA were extracted by phenol-chlorofrom method from blood samples. Genetic single-nucleotide polymorphisms were divided by Taqman real-time PCR. All statistical analyses were performed with statistical product and service solutions v13.0. p<0.05 was confirmed statistically significant. We used χ2 analysis to compare the differences in demographic characteristics, exposure to risk factors and SNPs genotypes between the two cases. Crude odds ratios(ORs) with 95% confidence intervals (95%CI) were calculated by Logistic regression analysis. Among the 170 patients, 112 suffered from non small cell lung cancer, 58 small cell lung cancer, 33 radiation-induced lung injury (≥2 grade). 2 grade were 21 cases, 3 grade were 9 cases, 4 grade were 1 case, 5 grade were 2 cases. Male were 26 cases (78.8%), female were 7 cases(21.2%). There were no significant association among general characteristic, treatment and the radiation-induced lung injury. There were no obvious relationship between genetic single-nucleotide polymorphisms of LIG4 and HSPB1 and the radiation-induced lung injury in lung cancer patients.Cited