放射性肺纤维化的分子机制及其防治药物综述
Review on molecular mechanisms and protective drugs research on radiation-induced lung fibrosis
- 辐射研究与辐射工艺学报 2016年34卷第1期 页码：10101
- 作者机构：
1.北京协和医学院 & 中国医学科学院放射医学研究所 天津市放射医学与分子核医学重点实验室 天津 300192
2.Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Science, Tianjin 300192, China
- 作者简介：
郑啓盛，男，1989年3 月出生，2013 年毕业于井冈山大学，目前为在读硕士研究生
刘培勋，研究员，E-mail: liupeixun@irm-cams.ac.cn
- 基金信息：北京协和医学院协和青年创新基金(1568)和中国医学科学院放射医学研究所探索基金(1560)资助ZHENG Qisheng, male, was born in March 1989 and graduated from Jinggangshan University in 2013. Now he is a master candidate of Peking Union Medical College
DOI：10.11889/j.1000-3436.2016.rrj.34.010101
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郑啓盛, 刘培勋. 放射性肺纤维化的分子机制及其防治药物综述[J]. 辐射研究与辐射工艺学报, 2016,34(1):10101.
Qisheng ZHENG, Peixun LIU. Review on molecular mechanisms and protective drugs research on radiation-induced lung fibrosis[J]. Journal of Radiation Research and Radiation Processing, 2016,34(1):10101.
郑啓盛, 刘培勋. 放射性肺纤维化的分子机制及其防治药物综述[J]. 辐射研究与辐射工艺学报, 2016,34(1):10101. DOI： 10.11889/j.1000-3436.2016.rrj.34.010101.
Qisheng ZHENG, Peixun LIU. Review on molecular mechanisms and protective drugs research on radiation-induced lung fibrosis[J]. Journal of Radiation Research and Radiation Processing, 2016,34(1):10101. DOI： 10.11889/j.1000-3436.2016.rrj.34.010101.
摘要
对放射性肺纤维化(Radiation-induced lung fibrosis,RILF)的发生、发展和最终形成过程中涉及到的细胞、细胞因子、信号通路以及关键因子进行归纳、总结和讨论，并给出具有潜在治疗作用的靶点以及作用在该靶点的相关药物，为今后研发预防与治疗RILF的药物提供思路。
Abstract
The current understanding of the cells, cytokines, and the key factors linked to the signaling networks implicated in RILF were summarized. Targets with potential therapeutic effects for the treatment of RILF were also be discussed and listed. From all above, we hope to provide researchers with ideas in studying the drugs with prevention and (or) the treatment of RILF.
关键词
放射性肺纤维化分子机制细胞因子防护药物综述
Keywords
Radiation-induced lung fibrosis(RILF)Molecular mechanismsCytokinesProtective drugsReview
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