纳米金在肿瘤检测及放射治疗中的应用

韦贵生; 相法伟; 田甜; 林承列; 李茜; 李江; 王丽华

doi:10.11889/j.1000-3436.2016.rrj.34.040103

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纳米金在肿瘤检测及放射治疗中的应用

综述 | 更新时间：2021-12-10

- 纳米金在肿瘤检测及放射治疗中的应用
- Application of gold nanoparticles in tumor detection and radiation therapy
- 辐射研究与辐射工艺学报 2016年34卷第4期页码：17-22
- 作者机构：
  
  1.中国科学院上海应用物理研究所物理生物学研究室与上海同步辐射光源生物成像中心嘉定园区上海 201800
  2.山东省潍坊市人民医院放射科潍坊 261000
- 作者简介：
  
  [ "韦贵生,男,1990年2月出生,2016年于中国科学院上海应用物理研究所获得硕士学位,生物物理学专业,研究领域为生物检测与分析", "WEI Guisheng (male) was born in February 1990 and graduated from Shanghai Institute of Applied Physics, ChineseAcademy of Sciences with a master degree in biophysics in 2016, majoring in bio-detection and analysis" ]
  李江,博士,副研究员,E-mail:lijiang@sinap.ac.cn Ph.D. LI Jiang, associate professor, E-mail:lijiang@sinap.ac.cn
- 基金信息：
  
  国家自然科学基金(21505148、21422508、31470960);国家重点基础研究发展计划(2012CB932603、2013CB933802)
- DOI：10.11889/j.1000-3436.2016.rrj.34.040103
  中图分类号：
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韦贵生, 相法伟, 田甜, 等. 纳米金在肿瘤检测及放射治疗中的应用[J]. 辐射研究与辐射工艺学报, 2016,34(4):17-22.

Guisheng WEI, Fawei XIANG, Tian TIAN, et al. Application of gold nanoparticles in tumor detection and radiation therapy[J]. Journal of Radiation Research and Radiation Processing, 2016,34(4):17-22.
韦贵生, 相法伟, 田甜, 等. 纳米金在肿瘤检测及放射治疗中的应用[J]. 辐射研究与辐射工艺学报, 2016,34(4):17-22. DOI： 10.11889/j.1000-3436.2016.rrj.34.040103.

Guisheng WEI, Fawei XIANG, Tian TIAN, et al. Application of gold nanoparticles in tumor detection and radiation therapy[J]. Journal of Radiation Research and Radiation Processing, 2016,34(4):17-22. DOI： 10.11889/j.1000-3436.2016.rrj.34.040103.

摘要

简述纳米金探针的组装和检测原理，总结了纳米金探针在肿瘤细胞检测、医学成像和放射治疗中的应用进展，并对其在今后的应用发展前景进行了展望。

Abstract

Preparation and working principle of molecular probes based on gold nanoparticles were introduced, and recent application of these probes as tumor imaging agents and radiosensitizers in tumor detection and radiation therapy were summarized, and application prospects of gold nanoparticles were provided.

关键词

纳米金生物探针肿瘤检测放射治疗

Keywords

Gold nanoparticlesBioprobesTumor detectionRadiotherapy

references

D K Eric . Engines of creation:the coming era of nanotechnology, :New YorkDoubleday Press , 1986 .

G Frens . Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions . Nature , 1973 . 241 (105 ):20 -22 . DOI:10.1038/physci241020a0http://doi.org/10.1038/physci241020a0 .

F M Kuni , A K Shchekin , A I Rusanov . Thermodynamics of condensation on soluble nuclei of surface-inactive substances . Colloid Journal of the Russian Academy of Sciences , 1993 . 55 (2 ):174 -183 . https://www.researchgate.net/publication/228078574_Thermodynamics_of_condensation_on_soluble_nuclei_of_surface_-_inactive_substanceshttps://www.researchgate.net/publication/228078574_Thermodynamics_of_condensation_on_soluble_nuclei_of_surface_-_inactive_substances, .

J Gardea-Torresdey , K Tiemann , G Gamez , 等 . Gold nanoparticles obtained by bio-precipitation from gold (Ⅲ) solutions . Journal of Nanoparticle Research , 1999 . 1 (3 ):397 -404 . DOI:10.1023/A:1010008915465http://doi.org/10.1023/A:1010008915465 .

X Dai , Y Tan , J Xu . Formation of gold nanoparticles in the presence of o-anisidine and the dependence of the structure of poly (o-anisidine) on synthetic conditions . Langmuir , 2002 . 18 (23 ):9010 -9016 . DOI:10.1021/la025926uhttp://doi.org/10.1021/la025926u .

Ruibo ZHONG , Yushuang LIU , Ping ZHANG , 等 . A facile method to build a proton nanosensor with neutral to basic pH sensitive range . Nuclear Science and Techniques (in China) , 2014 . 25 (4 ):040503 DOI:10.13538/j.1001-8042/nst.25.040503http://doi.org/10.13538/j.1001-8042/nst.25.040503 .

Dan ZHU , Min LI , Lihua WANG , 等 . A micro e-DNA sensor for selective detection of dopamine in presence of ascorbic acid . Nuclear Science and Techniques (in China) , 2005 . 26 (6 ):060504 DOI:10.13538/j.1001-8042/nst.26.060504http://doi.org/10.13538/j.1001-8042/nst.26.060504 .

E Hutter , D Maysinger . Gold nanoparticles and quantum dots for bioimaging . Microscopy Research and Technique , 2011 . 74 (7 ):592 -604 . DOI:10.1002/jemt.20928http://doi.org/10.1002/jemt.20928 .

C Burda , X Chen , R Narayanan , 等 . Chemistry and properties of nanocrystals of different shapes . Chemical Reviews , 2005 . 105 (4 ):1025 -1102 . DOI:10.1021/cr030063ahttp://doi.org/10.1021/cr030063a .

M Q Zhu , L Q Wang , G J Exarhos , 等 . Thermosensitive gold nanoparticles . Journal of the American Chemical Society , 2004 . 126 (9 ):2656 -2657 . DOI:10.1021/ja038544zhttp://doi.org/10.1021/ja038544z .

J F Hainfeld , D N Slatkin , H M Smilowitz . The use of gold nanoparticles to enhance radiotherapy in mice . Physics in Medicine and Biology , 2004 . 49 (18 ):N309 DOI:10.1088/0031-9155/49/18/N03http://doi.org/10.1088/0031-9155/49/18/N03 .

F Xiao , Y Zheng , P Cloutier , 等 . On the role of low-energy electrons in the radiosensitization of DNA by gold nanoparti-cles . Nanotechnology , 2011 . 22 (46 ):465101 DOI:10.1088/0957-4484/22/46/465101http://doi.org/10.1088/0957-4484/22/46/465101 .

J I Cutler , E Auyeung , C A Mirkin . Spherical nucleic acids . Journal of the American Chemical Society , 2012 . 134 (3 ):1376 -1391 . DOI:10.1021/ja209351uhttp://doi.org/10.1021/ja209351u .

D S Seferos , D A Giljohann , H D Hill , 等 . Nano-flares:probes for transfection and mRNA detection in living cells . Journal of the American Chemical Society , 2007 . 129 (50 ):15477 -15479 . DOI:10.1021/ja0776529http://doi.org/10.1021/ja0776529 .

N Li , C Chang , W Pan , 等 . A multicolor nanoprobe for detection and imaging of tumor-related mRNAs in living cells . Angewandte Chemie International Edition , 2012 . 51 (30 ):7426 -7430 . DOI:10.1002/anie.201203767http://doi.org/10.1002/anie.201203767 .

W E Briley , M H Bondy , P S Randeria , 等 . Quantification and real-time tracking of RNA in live cells using Sticky-flares . Proceedings of the National Academy of Sciences , 2015 . 112 (31 ):9591 -9595 . DOI:10.1073/pnas.1510581112http://doi.org/10.1073/pnas.1510581112 .

T L Halo , K M McMahon , N L Angeloni , 等 . NanoFlares for the detection, isolation, and culture of live tumor cells from human blood . Proceedings of the National Academy of Sciences , 2014 . 111 (48 ):17104 -17109 . DOI:10.1073/pnas.1418637111http://doi.org/10.1073/pnas.1418637111 .

R Q Liang , W Li , Y Li , 等 . An oligonucleotide microarray for microRNA expression analysis based on labeling RNA with quantum dot and nanogold probe . Nucleic Acids Research , 2005 . 33 (2 ):e17 DOI:10.1093/nar/gni019http://doi.org/10.1093/nar/gni019 .

C Wang , H Zhang , D Zeng , 等 . Elaborately designed diblock nanoprobes for simultaneous multicolor detection of microRNAs . Nanoscale , 2015 . 7 (38 ):15822 -15829 . DOI:10.1039/C5NR04618Ahttp://doi.org/10.1039/C5NR04618A .

X Zhao , L Xu , M Sun , 等 . Gold-quantum dot core-satellite assemblies for lighting up microRNA in vitro and in vivo . Small , 2016 . DOI:10.1002/small.201503629http://doi.org/10.1002/small.201503629 .

J H Hubbell , S M Seltzer . Tables of X-ray mass attenuation coefficients and mass energy-absorption coefficients (version 1.4) . National Institute of Standards and Technology, Gaithersburg, MD , 2004 .

J Hainfeld , D Slatkin , T Focella , 等 . Gold nanoparticles:a new X-ray contrast agent . The British Journal of Radiology , 2006 . 79 (939 ):248 -253 . DOI:10.1259/bjr/13169882http://doi.org/10.1259/bjr/13169882 .

D Kim , S Park , J H Lee , 等 . Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging . Journal of the American Chemical Society , 2007 . 129 (24 ):7661 -7665 . DOI:10.1021/ja071471phttp://doi.org/10.1021/ja071471p .

F Spiers . The influence of energy absorption and electron range on dosage in irradiated bone . The British Journal of Radiology , 1949 . 22 (261 ):521 -533 . DOI:10.1259/0007-1285-22-261-521http://doi.org/10.1259/0007-1285-22-261-521 .

M H Castillo , T M Button , R Doerr , 等 . Effects of radiotherapy on mandibular reconstruction plates . The American Journal of Surgery , 1988 . 156 (4 ):261 -263 . DOI:10.1016/S0002-9610(88)80287-3http://doi.org/10.1016/S0002-9610(88)80287-3 .

M Y Chang , A L Shiau , Y H Chen , 等 . Increased apoptotic potential and dose-enhancing effect of gold nanoparticles in combination with single-dose clinical electron beams on tumor-bearing mice . Cancer Science , 2008 . 99 (7 ):1479 -1484 . DOI:10.1111/j.1349-7006.2008.00827.xhttp://doi.org/10.1111/j.1349-7006.2008.00827.x .

B A Rupnow , A D Murtha , R M Alarcon , 等 . Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy . Cancer Research , 1998 . 58 (9 ):1779 -1784 . http://cn.bing.com/academic/profile?id=1753384618&encoded=0&v=paper_preview&mkt=zh-cnhttp://cn.bing.com/academic/profile?id=1753384618&encoded=0&v=paper_preview&mkt=zh-cn, .

B Rupnow , S Knox . The role of radiation-induced apoptosis as a determinant of tumor responses to radiation therapy . Apoptosis , 1999 . 4 (2 ):115 -143 . DOI:10.1023/A:1009675028784http://doi.org/10.1023/A:1009675028784 .

M Verheij , H Bartelink . Radiation-induced apoptosis . Cell and Tissue Research , 2000 . 301 (1 ):133 -142 . DOI:10.1007/s004410000188http://doi.org/10.1007/s004410000188 10.1007/s00441000018810.1007/s004410000188, .

J F Hainfeld , H M Smilowitz , M J O'Connor , 等 . Gold nanoparticle imaging and radiotherapy of brain tumors in mice . Nanomedicine , 2013 . 8 (10 ):1601 -1609 . DOI:10.2217/nnm.12.165http://doi.org/10.2217/nnm.12.165 .

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