基于剂量分布指数选择胸部肿瘤最优放疗计划的可行性分析

孟慧鹏; 冯远明; 董化江

doi:10.11889/j.1000-3436.2017.rrj.35.010204

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基于剂量分布指数选择胸部肿瘤最优放疗计划的可行性分析

辐射生物学与医学 | 更新时间：2021-12-10

- 基于剂量分布指数选择胸部肿瘤最优放疗计划的可行性分析
- Feasibility analysis of selecting optimal radiotherapy plan for chest tumor based on dose distribution index
- 辐射研究与辐射工艺学报 2017年35卷第1期页码：10204
- 作者机构：
  
  1.天津大学精密仪器与光电子工程学院天津 300072
  2.武警后勤学院附属医院放疗中心天津 300162
- 作者简介：
  
  [ "孟慧鹏, 男, 1981年10月出生, 2011年于南开大学获得硕士学位, 现为天津大学博士研究生, 主要从事肿瘤放射治疗物理学及网络相关的研究工作", "MENG Huipeng (male) was born in October 1981, and received his master’s degree from Nankai University in 2011.Now he is a doctor candidate in Tianjin University, engaging in radiotherapy physics for tumor and network-related research" ]
  冯远明, 博士, 教授, E-mail:ymfeng@tju.edu.cnPh.D. FENG Yuanming, professor, E-mail:ymfeng@tju.edu.cn
- 基金信息：
  
  武警后勤学院附属医院种子基金项目(FYM201620)
- DOI：10.11889/j.1000-3436.2017.rrj.35.010204
  中图分类号：
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孟慧鹏, 冯远明, 董化江. 基于剂量分布指数选择胸部肿瘤最优放疗计划的可行性分析[J]. 辐射研究与辐射工艺学报, 2017,35(1):10204.

Huipeng MENG, Yuanming FENG, Huajiang DONG. Feasibility analysis of selecting optimal radiotherapy plan for chest tumor based on dose distribution index[J]. Journal of Radiation Research and Radiation Processing, 2017,35(1):10204.
孟慧鹏, 冯远明, 董化江. 基于剂量分布指数选择胸部肿瘤最优放疗计划的可行性分析[J]. 辐射研究与辐射工艺学报, 2017,35(1):10204. DOI： 10.11889/j.1000-3436.2017.rrj.35.010204.

Huipeng MENG, Yuanming FENG, Huajiang DONG. Feasibility analysis of selecting optimal radiotherapy plan for chest tumor based on dose distribution index[J]. Journal of Radiation Research and Radiation Processing, 2017,35(1):10204. DOI： 10.11889/j.1000-3436.2017.rrj.35.010204.

摘要

用剂量分布指数（Dose distribution index，DDI）回顾分析50例胸部肿瘤患者的放疗计划，根据肿瘤的位置将病例分成3组：常规组、病灶靠近需保护敏感组织组、胸壁组。每位患者设计3份备选计划，每个备选计划均计算DDI得分，最终有一个备选计划用于实际治疗。靶区的覆盖与治疗区所有组织同等重要时，70.0%（35/50）DDI得分高的计划与实际治疗选择的计划一致，当给予靶区或者脊髓和肺更高的权值后，不一致的结果中又有86.7%（13/15）得分高的与实际治疗选择保持一致。DDI指数提供了一种基于剂量体积直方图（Dose volume histogram，DVH）的客观评价备选放疗计划优劣的工具，尤其在DVH显示非常接近的备选计划中，DDI指数仍可很好的区分其不同，对最终胸部放疗计划的选取提供可靠的依据。

Abstract

Dose distribution index (DDI) for fifty chest tumor patients were retrospectively evaluated. The patients were divided into three groups depending on tumor location, including the conventional group, the group with lesion close to the sensitive tissues to be protected, and the chest wall group. For each patient, three tentative plans were designed and recorded during planning, one of which was eventually selected for treatment. When planning target coverage and organs at risk sparing are considered as equally important, the tentative plan with the highest DDI score is shown to coincide with that actually delivered in 35 of the 50 patients considered (70.0%). In 13 of the remaining 15 cases (86.7%), the plan with highest DDI value still coincides with that actually selected, provided that some organs at risk sparing or target coverage is given higher priority than others. DDI provides a non-subjective tool for dosimetric comparison of tentative radiotherapy plans. In particular, DDI readily quantifies differences among competing plans with similar-looking dose-volume histograms and can be easily implemented. It provides a reliable basis to select the best among the tentative radiotherapy plans.

关键词

剂量分布指数胸部肿瘤可行性分析放疗计划

Keywords

Dose distribution index (DDI)Chest tumorFeasibility analysisRadiotherapy plan

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