外泌体检测在肿瘤放化疗中的应用

李俊俊; 涂文志; 刘勇

doi:10.11889/j.1000-3436.2017.rrj.35.030102

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外泌体检测在肿瘤放化疗中的应用

综述 | 更新时间：2021-12-10

- 外泌体检测在肿瘤放化疗中的应用
- Advances of exosome research in cancer radiotherapy and chemotherapy
- 辐射研究与辐射工艺学报 2017年35卷第3期
- 作者机构：
  
  1.上海交通大学附属第一人民医院肿瘤中心上海 201620
- 作者简介：
  
  [ "李俊俊, 女, 1992年2月出生, 2016年毕业于安徽理工大学, 上海交通大学2016级硕士研究生, 研究方向为肿瘤放疗, E-mail:694219862@qq.com", "LI Junjun (female) was born in February 1992, and graduated from Anhui University of Science and Technology in 2016. Now she is a master candidate in Shanghai Jiao Tong University, majoring in Oncology, E-mail: 694219862@qq.com" ]
  刘勇, 博士, 副教授, E-mail:drliuyrt@163.com Ph.D. LIU Yong, associate professor, E-mail: drliuyrt@163.com
- 基金信息：
  
  国家自然科学基金资助项目(31370838);国家自然科学基金资助项目(81602663);教育部归国留学启动基金(N130204);上海市卫生和计划生育委员会科研课题(20164Y0037)
- DOI：10.11889/j.1000-3436.2017.rrj.35.030102
  中图分类号：
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李俊俊, 涂文志, 刘勇. 外泌体检测在肿瘤放化疗中的应用[J]. 辐射研究与辐射工艺学报, 2017,35(3):030102-8.

Junjun LI, Wenzhi TU, Yong LIU. Advances of exosome research in cancer radiotherapy and chemotherapy[J]. Journal of Radiation Research and Radiation Processing, 2017,35(3):030102-8.
李俊俊, 涂文志, 刘勇. 外泌体检测在肿瘤放化疗中的应用[J]. 辐射研究与辐射工艺学报, 2017,35(3):030102-8. DOI： 10.11889/j.1000-3436.2017.rrj.35.030102.

Junjun LI, Wenzhi TU, Yong LIU. Advances of exosome research in cancer radiotherapy and chemotherapy[J]. Journal of Radiation Research and Radiation Processing, 2017,35(3):030102-8. DOI： 10.11889/j.1000-3436.2017.rrj.35.030102.

摘要

本文就外泌体的提取、富集、追踪及其在放化疗中的应用进展进行综述。目前外泌体提取与富集的主要方法包括超速离心法，层析法和色谱法等，外泌体可通过荧光素酶标记进行追踪。由于外泌体具有特异的表面标志物及其在体液中广泛存在的特点，使其成为潜在的肿瘤标志物之一。此外，外泌体在肿瘤的辐射敏感性与辐射损伤、肿瘤的靶向治疗和多重耐药等放化疗中的作用也日益受到关注。

Abstract

Here, we summarized the isolation, enrichment, and tracking of exosome, as well as its application in radio-and chemotherapy of cancer. Currently, the main extracting methods of exosome include ultracentrifugation, ultrafiltration, and chromatography. Exosome can be tracked by luciferase labeling. Exosome is characterized by specific surface markers and exists in most body fluids, which makes it a potential cancer marker. Moreover, increasing researches have focused on the vital role of exosomes in radiosensitivity, radiation damage, targeted therapy, and multidrug resistance of cancer cells.

关键词

外泌体放疗化疗肿瘤综述

Keywords

ExosomesRadiotherapyChemotherapyCancerReview

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