铀的几种常见促排剂的研究进展

肖奕铭; 黄德娟; 任强; 耿彥霞; 黄德超; 唐旭银; 周峥

doi:10.11889/j.1000-3436.2017.rrj.35.040102

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铀的几种常见促排剂的研究进展

综述 | 更新时间：2021-12-10

- 铀的几种常见促排剂的研究进展
- Research progress on some uranium mobilization agents
- 辐射研究与辐射工艺学报 2017年35卷第4期
- 作者机构：
  
  1.东华理工大学核资源与环境教育部重点实验室南昌 330013
  2.东华理工大学核科学与工程学院南昌 330013
  3.东华理工大学化学生物与材料学院南昌 330013
- 作者简介：
  
  [ "肖奕铭, 男, 1996年出生, 现为东华理工大学在读本科生, 从事放射化学研究", "XIAO Yiming (male) was born in 1996. Now he is an undergraduate in East China Institute of Technology, majoring in radiation chemistry" ]
  黄德娟, 教授, E-mail:djhuang@ecit.cn HUANG Dejuan, professor, E-mail:djhuang@ecit.cn
- 基金信息：
  
  国家自然科学基金(41361088);江西省教育厅重点科技项目(GJJ13473);江西省科技厅科技支撑项目(20122BBG70084-1);江西省对外科技合作计划项目(20151BDH80041);核资源与环境重点实验室开放基金资助项目(NRE1410);国家级大学生创新创业训练计划项目(201510405015)
- DOI：10.11889/j.1000-3436.2017.rrj.35.040102
  中图分类号：
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肖奕铭, 黄德娟, 任强, 等. 铀的几种常见促排剂的研究进展[J]. 辐射研究与辐射工艺学报, 2017,35(4):040102-7.

Yiming XIAO, Dejuan HUANG, Qiang REN, et al. Research progress on some uranium mobilization agents[J]. Journal of Radiation Research and Radiation Processing, 2017,35(4):040102-7.
肖奕铭, 黄德娟, 任强, 等. 铀的几种常见促排剂的研究进展[J]. 辐射研究与辐射工艺学报, 2017,35(4):040102-7. DOI： 10.11889/j.1000-3436.2017.rrj.35.040102.

Yiming XIAO, Dejuan HUANG, Qiang REN, et al. Research progress on some uranium mobilization agents[J]. Journal of Radiation Research and Radiation Processing, 2017,35(4):040102-7. DOI： 10.11889/j.1000-3436.2017.rrj.35.040102.

摘要

分析了铀对肺、肾、骨骼、生殖器等人体多种重要器官的毒性，综述了二乙基三胺五乙酸、邻苯二酚类、壳聚糖及其相关衍生物等铀促排解毒药物的研究进展。当前研究目标是对促排剂进行改造，增强解毒能力并降低毒副作用。

Abstract

The toxicity of uranium to various vital organs such as the lung, kidney, bone, and genitals was analyzed, and the research progress of uranium mobilization agents such as diethylenetriaminepentaacetic acid, catechol, chitosan, and related derivatives, was summarized. The purpose of this study is to promote the use of chelating agents to enhance their detoxification capacity and reduce the side effects.

关键词

铀促排剂综述

Keywords

UraniumChelating agentsReview

references

P W Durbin , B Kullgren , J Xu , 等 . New agents for in vivo chelation of uranium (Ⅵ): efficacy and toxicity in mice of multidentate catecholate and hydroxypyridinonate ligands . Health Physics , 1997 . 72 (6 ):865 -79 . DOI:10.1097/00004032-199706000-00006http://doi.org/10.1097/00004032-199706000-00006 .

M H Hengenapoli , M Archimbaud , E Ansoborlo , 等 . Efficacy of 3, 4, 3-LIHOPO for reducing the retention of uranium in rat after acute administration . International Journal of Radiation Biology , 1995 . 68 (4 ):389 -393 . DOI:10.1080/09553009514551331http://doi.org/10.1080/09553009514551331 .

刘玉龙 , 李明华 , 孙晓亮 , 等 . 贫铀的毒性及解毒促排药物研究进展 . 解放军药学学报 , 2014 . 30 (5 ):454 -458 . DOI:10.3969/j.issn.1008-9926.2014.05.024.LIUhttp://doi.org/10.3969/j.issn.1008-9926.2014.05.024.LIU .

Yulong LIU , Minghua LI , Xiaoliang SUN , 等 . Toxicity of depleted uranium and advances in drugs for detoxification . Pharmaceutical Journal of Chinese People's Liberation Army , 2014 . 30 (5 ):454 -458 . DOI:10.3969/j.issn.1008-9926.2014.05.024http://doi.org/10.3969/j.issn.1008-9926.2014.05.024 .

P Galle , R Masse . Uranium, in radionuclide: metabolism and toxicity , :Paris Masson , 1982 . 239 -253. .

B L'Azou , M H Hengenapoli , L Minaro , 等 . Effects of cadmium and uranium on some in vitro renal targets . Cell Biology and Toxicology , 2002 . 18 (5 ):329 -340 . DOI:10.1023/A:1019536115152http://doi.org/10.1023/A:1019536115152 .

Neuman WF. Deposition of uranium in bone[C]// Pharmacology and toxicology of uranium compounds: Part Ⅲ & Ⅳ. New York: McGraw-Hill Book Company, 1953: 1911-1991.

A M Ubios , M B Guglielmotti , T Steimetz , 等 . Uranium inhibits bone formation in physiologic alveolar bone modeling and remodeling . Environmental Research , 1991 . 54 (1 ):17 -23 . DOI:10.1016/S0013-9351(05)80191-4http://doi.org/10.1016/S0013-9351(05)80191-4 .

张晓菲 , 赵长琦 , 刘丽宏 . 贫铀的危害及铀促排剂的研究进展 . 北京师范大学学报(自然科学版) , 2010 . 46 (4 ):517 -521 . http://www.cnki.com.cn/Article/CJFDTOTAL-BSDZ201004024.htmhttp://www.cnki.com.cn/Article/CJFDTOTAL-BSDZ201004024.htm, .

Xiaofei ZHANG , Changqi ZHAO , Lihong LIU . Hazards of depleted uranium advance in uranium chelating agents research . Journal of Beijing Normal University (Natural Science) , 2010 . 46 (4 ):517 -521 . http://www.cnki.com.cn/Article/CJFDTOTAL-BSDZ201004024.htmhttp://www.cnki.com.cn/Article/CJFDTOTAL-BSDZ201004024.htm, .

J L Domingo . Reproductive and developmental toxicity of natural and depleted uranium: a review . Reproductive Toxicology , 2001 . 15 (6 ):603 -609 . DOI:10.1016/S0890-6238(01)00181-2http://doi.org/10.1016/S0890-6238(01)00181-2 .

N Shikazono , M Noguchi , K Fujii , 等 . The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation . Journal of Radiation Research , 2009 . 50 (1 ):27 -36 . DOI:10.1269/jrr.08086http://doi.org/10.1269/jrr.08086 .

A Asaithamby , B Hu , D J Chen . Unrepaired clustered DNA lesions induce chromosome breakage in human cells . Proceedings of the National Academy of Sciences of the United States of America , 2011 . 108 (20 ):8293 -8298 . DOI:10.1073/pnas.1016045108http://doi.org/10.1073/pnas.1016045108 .

吴福丽 , 王建营 , 延玺 , 等 . 铀促排化合物的研究进展 . 化学进展 , 2004 . 16 (3 ):438 -442 . DOI:10.3321/j.issn:1005-281X.2004.03.017.WUhttp://doi.org/10.3321/j.issn:1005-281X.2004.03.017.WU .

li Fu , Jianying WANG , Xi YAN , 等 . Advances in uranium chelating agents . Progress in Chemistry , 2004 . 16 (3 ):438 -442 . DOI:10.3321/j.issn:1005-281X.2004.03.017http://doi.org/10.3321/j.issn:1005-281X.2004.03.017 .

M W Rosentha , A Lindenba . Influence of DTPA therapy on long-term effects of retained monomeric plutonium: comparison with polymeric plutonium . Radiation Research , 1967 . 31 (3 ):506 -521 . DOI:10.2307/3572368http://doi.org/10.2307/3572368 .

A Seidel , V Volf . Removal of internally deposited transuranium elements by Zn-DTPA . Health Physics , 1972 . 22 (6 ):779 -783 . DOI:10.1097/00004032-197206000-00037http://doi.org/10.1097/00004032-197206000-00037 .

G N Taylor , R D Lloyd , J J Boseman , 等 . Removal of plutonium from beagles using Ca-DTPA and Zn-DTPA: effects on initial DTPA injection . Health Physics , 1978 . 35 (2 ):201 -210 . DOI:10.1097/00004032-197808000-00002http://doi.org/10.1097/00004032-197808000-00002 .

邓冰 , 王和义 , 蒋树斌 , 等 . 螯合剂对铀在小鼠体内分布的影响研究 . 原子能科学技术 , 2012 . 46 (8 ):912 -917 . http://www.cnki.com.cn/Article/CJFDTOTAL-YZJS201208004.htmhttp://www.cnki.com.cn/Article/CJFDTOTAL-YZJS201208004.htm, .

Bing DENG , Heyi WANG , Shubin JIANG , 等 . Influence of chelating agents on bio-distribution of uranium in mice . Atomic Energy Science and Technology , 2012 . 46 (8 ):912 -917 . http://www.cnki.com.cn/Article/CJFDTOTAL-YZJS201208004.htmhttp://www.cnki.com.cn/Article/CJFDTOTAL-YZJS201208004.htm, .

S Fukuda . Assessment of toxicity on chelating agent DTPA . Japanese Journal of Health Physics , 2010 . 24 201 -210 . DOI:10.5453/jhps.24.201http://doi.org/10.5453/jhps.24.201 .

Lusky L M, Braun H A. Sodium catechol disulphonate protection in experimental uranium nitrate poisoning[C]//Federation proceedings. 9650 Rockville pike, bethesda, MD 20814-3998: Federation of American Societies for Experimental Biology, 1950, 9(1): 297.

M A Basinger , M M Jones . Tiron (sodium 4, 5-dihydroxybenzene-1, 3-disulfonate) as an antidote for acute uranium intoxication in mice . Research Communications in Chemical Pathology and Pharmacology , 1981 . 34 (2 ):351 -358. .

J L Domingo , A delaTorre , M Belles , 等 . Comparative effects of the chelators sodium 4, 5-dihydroxybenzene-1, 3-disulfonate (tiron) and diethylenetriaminepentaacetic acid (DTPA) on acute uranium nephrotoxicity in rats . Toxicology , 1997 . 118 (1 ):49 -59 . DOI:10.1016/S0300-483X(96)03589-5http://doi.org/10.1016/S0300-483X(96)03589-5 .

A Ortega , D J Sánchez , J L Domingo , 等 . Developmental toxicity evaluation of tiron (sodium 4, 5-dihydroxybenzene-1, 3-disulfonate) in mice . Research Communications in Chemical Pathology & Pharmacology , 1991 . 73 (1 ):97 -106. .

罗梅初 , 陈桂宝 . 苯酚类螯合剂对铀中毒的解毒和排铀效果 . 中华放射医学与防护杂志 , 1992 . 12 (5 ):312 -315 . http://www.cnki.com.cn/Article/CJFDTOTAL-YLBS702.087.htmhttp://www.cnki.com.cn/Article/CJFDTOTAL-YLBS702.087.htm, .

Meichu LUO , Guibao CHEN . Effect of phenol-based chelating agents on uranium poisoning and uranium removal . Chinese Journal of Radiological Medicine and Protection (in China) , 1992 . 12 (5 ):312 -315 . http://www.cnki.com.cn/Article/CJFDTOTAL-YLBS702.087.htmhttp://www.cnki.com.cn/Article/CJFDTOTAL-YLBS702.087.htm, .

阮天明 , 罗梅初 , 沈彬源 , 等 . 7603, 8102对妊娠小鼠胚胎毒作用和致畸作用的研究 . 辐射防护 , 1987 . 7 (1 ):62 -65 . http://www.cnki.com.cn/Article/CJFDTOTAL-FSFH198701009.htmhttp://www.cnki.com.cn/Article/CJFDTOTAL-FSFH198701009.htm, .

Tianming RUAN , Meichu LUO , Binyuan SHEN , 等 . Studies of toxic and teratogenetic effects of 7603 and 8102 on gestational . Radiation Protection , 1987 . 7 (1 ):62 -65 . http://www.cnki.com.cn/Article/CJFDTOTAL-FSFH198701009.htmhttp://www.cnki.com.cn/Article/CJFDTOTAL-FSFH198701009.htm, .

李蓉 , 刘晶 , 任泂 , 等 . 黄酮类化合物对急性贫铀中毒的促排解毒作用初探 . 辐射研究与辐射工艺学报 , 2009 . 27 (1 ):20 -24 . DOI:10.3969/j.issn.1000-3436.2009.01.005.LIhttp://doi.org/10.3969/j.issn.1000-3436.2009.01.005.LI .

Rong LI , Jing LIU , Jiong REN , 等 . Study on decorporating and detoxicating acute depleted uranium poison with some flavonoids . Journal of Radiation Research and Radiation Processing , 2009 . 27 (1 ):20 -24 . DOI:10.3969/j.issn.1000-3436.2009.01.005http://doi.org/10.3969/j.issn.1000-3436.2009.01.005 .

U Justesen , E Arrigoni , B R Larsen , 等 . Degradation of flavonoid glycosides and aglycones during in vitro fermentation with human faecal flora . LWT-Food Science and Technology , 2000 . 33 (6 ):424 -430 . DOI:10.1006/fstl.2000.0681http://doi.org/10.1006/fstl.2000.0681 .

Q Zhang , B Jin , Z Shi , 等 . Novel enterobactin analogues as potential therapeutic chelating agents: Synthesis, thermodynamic and antioxidant studies . Scientific Reports , 2016 . 6 34024 DOI:10.1038/srep34024http://doi.org/10.1038/srep34024 .

张晓菲 , 刘河 , 刘丽宏 , 等 . 基于壳聚糖及其衍生物结构的体内铀促排剂的研究 . 北京师范大学学报(自然科学版) , 2008 . 44 (3 ):276 -280 . DOI:10.3321/j.issn:0476-0301.2008.03.014.ZHANGhttp://doi.org/10.3321/j.issn:0476-0301.2008.03.014.ZHANG .

Xiaofei ZHANG , He LIU , Lihong LIU , 等 . Uranium chelating agent based on modified chitosan resins . Journal of Beijing Normal University (Natural Science) , 2008 . 44 (3 ):276 -280 . DOI:10.3321/j.issn:0476-0301.2008.03.014http://doi.org/10.3321/j.issn:0476-0301.2008.03.014 .

张晓菲. 基于印迹壳低聚糖结构的铀促排剂的研究[D]. 北京: 北京师范大学, 2012.

ZHANG Xiaofei. Studies on uranium chelating agent from imprinted chitooligosaccharides based on their structure[D]. Beijing: Beijing Normal University, 2012.

胡丹飞 , 毕梦 , 袁海浪 , 等 . 新型促排剂WSC-DTPA纳米粒对内污染铀的促排和防护作用 . 辐射研究与辐射工艺学报 , 2013 . 31 (4 ):13 -18 . DOI:10.11889/j.1000-3436.2013.rrj.31.040202.HUhttp://doi.org/10.11889/j.1000-3436.2013.rrj.31.040202.HU http://www.j.sinap.ac.cn/fushe/CN/abstract/abstract54.shtmlhttp://www.j.sinap.ac.cn/fushe/CN/abstract/abstract54.shtml, .

Danfei HU , Meng BI , Hailang YUAN , 等 . Decorporation and radiation protection effects of WSC-DTPA nanopaticles on internal uranium exposure . Journal of Radiation Research and Radiation Processing , 2013 . 31 (4 ):13 -18 . DOI:10.11889/j.1000-3436.2013.rrj.31.040202http://doi.org/10.11889/j.1000-3436.2013.rrj.31.040202 http://www.j.sinap.ac.cn/fushe/CN/abstract/abstract54.shtmlhttp://www.j.sinap.ac.cn/fushe/CN/abstract/abstract54.shtml, .

何佳恒 , 刘国平 , 张华明 , 等 . 富勒烯大环多胺衍生物的合成及对铀的促排 . 核技术 , 2013 . 36 (12 ):25 -33 . DOI:10.11889/j.0253-3219.2013.hjs.36.120301.HEhttp://doi.org/10.11889/j.0253-3219.2013.hjs.36.120301.HE .

Jiaheng HE , Guoping LIU , Huaming ZHANG , 等 . Synthesis of a fullerene macrocyclic derivative and its effect on excretion promotion of uranium . Nuclear Techniques , 2013 . 36 (12 ):25 -33 . DOI:10.11889/j.0253-3219.2013.hjs.36.120301http://doi.org/10.11889/j.0253-3219.2013.hjs.36.120301 .

陈琪萍 , 何佳恒 , 王关全 , 等 . 富勒烯单大环多胺衍生物对辐射引起小鼠急性肝损伤的保护作用研究 . 核技术 , 2014 . 37 (8 ):17 -22 . DOI:10.11889/j.0253-3219.2014.hjs.37.080301.CHENhttp://doi.org/10.11889/j.0253-3219.2014.hjs.37.080301.CHEN .

Qiping CHEN , Jiaheng HE , Guanquan WANG , 等 . Protective effect of fullerene derivatives against X-ray-induced mitochondria damage in rat liver . Nuclear Techniques , 2014 . 37 (8 ):17 -22 . DOI:10.11889/j.0253-3219.2014.hjs.37.080301http://doi.org/10.11889/j.0253-3219.2014.hjs.37.080301 .

陈文 , 宋宏涛 , 魏洪源 , 等 . 意外吸入核素的促排现状概述 . 辐射研究与辐射工艺学报 , 2012 . 30 (1 ):8 -13 . DOI:10.11889/j.1000-3436.2012.rrj.30.120102.CHENhttp://doi.org/10.11889/j.1000-3436.2012.rrj.30.120102.CHEN http://www.j.sinap.ac.cn/fushe/CN/abstract/abstract197.shtmlhttp://www.j.sinap.ac.cn/fushe/CN/abstract/abstract197.shtml, .

Wen CHEN , Hongtao SONG , Hongyuan WEI , 等 . Summarization on the current status of nuclide decorporating inhaled in accident . Journal of Radiation Research and Radiation Processing , 2012 . 30 (1 ):8 -13 . DOI:10.11889/j.1000-3436.2012.rrj.30.120102http://doi.org/10.11889/j.1000-3436.2012.rrj.30.120102 http://www.j.sinap.ac.cn/fushe/CN/abstract/abstract197.shtmlhttp://www.j.sinap.ac.cn/fushe/CN/abstract/abstract197.shtml, .

A M Ubios , E M Braun , R L Cabrini . Lethality due to uranium poisoning is prevented by ethane-1-hydroxy-1, 1-biphosphonate(EHBP) . Health Physics , 1994 . 66 (5 ):540 -544 . DOI:10.1097/00004032-199405000-00005http://doi.org/10.1097/00004032-199405000-00005 .

A B Martinez , P M Mandalunis , C B Bozal , 等 . Renal function in mice poisoned with oral uranium and treated with ethane-1-hydroxy-1, 1-bisphosphonate (EHBP) . Health Physics , 2003 . 85 (3 ):343 -347 . DOI:10.1097/00004032-200309000-00010http://doi.org/10.1097/00004032-200309000-00010 .

A M Ubios , E M Braun , R L Cabrini . Effect of biphosphonates on abnormal mandibular growth of rats intoxicated with uranium . Health Physics , 1998 . 75 (6 ):610 -613 . DOI:10.1097/00004032-199812000-00004http://doi.org/10.1097/00004032-199812000-00004 .

陈洁 , 杨铭鼎 . 无氰电镀络合剂羟基乙叉二膦酸二钠盐的毒性研究 . 复旦学报(医学版) , 1983 . 10 (6 ):447 -452 . http://www.cnki.com.cn/Article/CJFDTOTAL-SHYK198306008.htmhttp://www.cnki.com.cn/Article/CJFDTOTAL-SHYK198306008.htm, .

Jie CHEN , Mingding YANG . Toxicity assessment of the non-cyanide electroplating complexing agent: 1-hydroxy-ethylidene-1, 1-disodium phosphonate (HEDP) . Fudan University Journal of Medical Sciences , 1983 . 10 (6 ):447 -452 . http://www.cnki.com.cn/Article/CJFDTOTAL-SHYK198306008.htmhttp://www.cnki.com.cn/Article/CJFDTOTAL-SHYK198306008.htm, .

冯国昌 , 刘萍 , 禚金花 , 等 . DHPO生殖毒性的毒理学评价 . 中国公共卫生 , 2006 . 22 (10 ):1209 -1210 . DOI:10.11847/zgggws2006-22-10-33.FENGhttp://doi.org/10.11847/zgggws2006-22-10-33.FENG .

Guochang FENG , Ping LIU , Jinhua ZHUO , 等 . Primary study about reproductive toxicology of DHPO in mice . Chinese Journal of Public Health , 2006 . 22 (10 ):1209 -1210 . DOI:10.11847/zgggws2006-22-10-33http://doi.org/10.11847/zgggws2006-22-10-33 .

B Jin , R Zheng , R Peng , 等 . Synthesis of new bis (3-hydroxy-4-pyridinone) ligands as chelating agents for uranyl complexation . Molecules , 2016 . 21 (3 ):299 DOI:10.3390/molecules21030299http://doi.org/10.3390/molecules21030299 .

F Lahrouch , A C Chamayou , G Creff , 等 . A combined spectroscopic/molecular dynamic study for investigating a methyl-carboxylated PEI as a potential uranium decorporation agent . Inorganic Chemistry , 2017 . 56 (3 ):1300 -1308 . DOI:10.1021/acs.inorgchem.6b02408http://doi.org/10.1021/acs.inorgchem.6b02408 .

N Oku , N Yamaguchi , N Yamaguchi , 等 . The fusogenic effect of synthetic polycations on negatively charged lipid bilayers . Journal of Biochemistry , 1986 . 100 (4 ):935 -944 . DOI:10.1093/oxfordjournals.jbchem.a121806http://doi.org/10.1093/oxfordjournals.jbchem.a121806 .

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