一氧化氮清除剂Fe（DETC）2对小鼠的辐射防护作用
Radioprotective effects of a nitric oxide scavenger, Fe (DETC)2, on mice
- 辐射研究与辐射工艺学报 2017年35卷第4期
- 作者机构：
1.中国医学科学院 北京协和医学院 放射医学研究所 天津 300192
- 作者简介：
[ "李园园, 女, 1992年11月出生, 2015年毕业于烟台大学, 现为中国医学科学院放射医学研究所药物化学专业硕士研究生, E-mail:yuanyuanli0929@163.com", "LI Yuanyuan (female) was born in November 1992, and graduated from Yantai University in 2015. Now she is a master candidate in the Institute of Radiation Medicine, Chinese Academy of Medical Sciences, majoring in pharmaceutical chemistry.E-mail:yuanyuanli0929@163.com" ]
徐文清, 研究员, E-mail:xuwenqing@irm-cams.ac.cn XU Wenqing, professor, E-mail:xuwenqing@irm-cams.ac.cn
- 基金信息：国家自然科学基金项目(81273005);天津市应用基础与前沿技术研究重点项目(14JCZDJC36400)
DOI：10.11889/j.1000-3436.2017.rrj.35.040203
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李园园, 张宇睿, 徐文清. 一氧化氮清除剂Fe（DETC）2对小鼠的辐射防护作用[J]. 辐射研究与辐射工艺学报, 2017,35(4):040203-5.
Yuanyuan LI, Yurui ZHANG, Wenqing XU. Radioprotective effects of a nitric oxide scavenger, Fe (DETC)2, on mice[J]. Journal of Radiation Research and Radiation Processing, 2017,35(4):040203-5.
李园园, 张宇睿, 徐文清. 一氧化氮清除剂Fe（DETC）2对小鼠的辐射防护作用[J]. 辐射研究与辐射工艺学报, 2017,35(4):040203-5. DOI： 10.11889/j.1000-3436.2017.rrj.35.040203.
Yuanyuan LI, Yurui ZHANG, Wenqing XU. Radioprotective effects of a nitric oxide scavenger, Fe (DETC)2, on mice[J]. Journal of Radiation Research and Radiation Processing, 2017,35(4):040203-5. DOI： 10.11889/j.1000-3436.2017.rrj.35.040203.
摘要
采用小鼠30 d存活率实验和外周血白细胞、骨髓DNA含量、脾克隆形成单位及各脏器指数指标考察NO特异性清除剂二乙基二硫代氨基甲酸亚铁（Fe（DETC）,2,）对辐射损伤小鼠的保护作用。结果显示，与单纯照射组相比，给予不同剂量Fe（DETC）,2,后，照射给药组小鼠30 d存活率、外周血白细胞数、骨髓DNA含量、脾克隆形成单位及各脏器指数均有不同程度的提高，特别是二乙基二硫代氨基甲酸钠（DETC）以300 mg/kg的剂量腹腔注射，可使存活率提高约43%，白细胞数、骨髓DNA含量和脾克隆形成单位与单纯照射组相比具有统计学意义（,p,<, 0.01）。结果提示，一氧化氮清除剂Fe（DETC）,2,对辐射损伤小鼠具有一定的保护作用。
Abstract
A 30-day survival rate experiment was carried out, and the assays of peripheral blood leukocytes, bone marrow DNA content, colony forming units of the spleen (CFU-S), and organ index parameters were analyzed to evaluate the protective effect of a nitric oxide-specific scavenger, Fe,2+,-diethyldithiocarbamate complex (Fe(DETC),2,), on radiation-injured mice. The results showed that compared with the irradiation group, the 30 d survival rate, peripheral blood leukocytes, bone marrow DNA content, CFU-S, and organ index were significantly different from those in the mice treated with different doses. In particular, DETC was administered intraperitoneally at a dose of 300 mg/kg, which increased the survival rate by about 43%, and changes in the number of white blood cells, bone marrow DNA content, and CFU-S were statistically significant (,p,<, 0.01). It is suggested that Fe(DETC),2, a nitric oxide scavenger, has a protective effect on radiation-injured mice.
关键词
NO清除剂Fe（DETC）2辐射防护
Keywords
Nitric oxide scavengerFe(DETC)2Radiation protection
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