液态基准标志物在图像引导放疗中的应用价值

黄昱霖; 杨海芳; 姜斌; 张旺; 张超; 刘建平; 田龙

doi:10.11889/j.1000-3436.2023-0031

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液态基准标志物在图像引导放疗中的应用价值

辐射生物学与医学 | 更新时间：2023-10-27

- 液态基准标志物在图像引导放疗中的应用价值
- Application value of liquid fiducial marker in image-guided radiotherapy
- 辐射研究与辐射工艺学报 2023年41卷第5期页码：50302
- 作者机构：
  
  1.唐山市人民医院唐山 063000
  2.河北北方学院附属第一医院张家口 075000
- 作者简介：
  
  黄昱霖，男，1991年8月出生，现就职于唐山市人民医院，研究方向为放射治疗学
  田龙，硕士，主任研究员，E-mail: 1277473912@qq.com
- 基金信息：
  
  唐山市重点研发计划项目(20211398)
- DOI：10.11889/j.1000-3436.2023-0031
  中图分类号：
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黄昱霖, 杨海芳, 姜斌, 等. 液态基准标志物在图像引导放疗中的应用价值[J]. 辐射研究与辐射工艺学报, 2023,41(5):050302.

HUANG Yulin, YANG Haifang, JIANG Bin, et al. Application value of liquid fiducial marker in image-guided radiotherapy[J]. Journal of Radiation Research and Radiation Processing, 2023,41(5):050302.
黄昱霖, 杨海芳, 姜斌, 等. 液态基准标志物在图像引导放疗中的应用价值[J]. 辐射研究与辐射工艺学报, 2023,41(5):050302. DOI： 10.11889/j.1000-3436.2023-0031.

HUANG Yulin, YANG Haifang, JIANG Bin, et al. Application value of liquid fiducial marker in image-guided radiotherapy[J]. Journal of Radiation Research and Radiation Processing, 2023,41(5):050302. DOI： 10.11889/j.1000-3436.2023-0031.

摘要

评价一种可降解的液态基准标志物（Liquid fiducial marker，LFM）在图像引导放疗中的应用价值。体外实验：以固态基准标志物（Solid fiducial marker，SFM）为参考，评价不同锥形束CT管电压条件下LFM的可视性、伪影和最优注量。体内实验：以SFM为参考，评价LFM在裸鼠体内的稳定性和降解状况。将种植了肿瘤细胞的裸鼠随机分为未注入LFM的单次放疗组（16 Gy/次），注入了LFM的单次（16 Gy/次）、二分次（8 Gy/次）和四分次放疗组（4 Gy/次）。根据照射结果评价LFM对肿瘤生长的影响。相比SFM，LFM的伪影显著较小（均,p,<,0.05），可视性满足临床鉴别要求，当注量为10 μL时成像质量最佳。裸鼠体内LFM质心相对脊髓位移显著大于黄金基准标志物（（0.22±0.03） mm ,vs., （0.17±0.02） mm，,p,<,0.05），但始终小于一个像素尺寸，故稳定性良好。LFM的实际降解率同理论降解率高度相符。LFM对单次放疗组肿瘤生长影响较小，对分次放疗组影响较大。LFM具有一定临床应用和推广价值，未来有望取代SFM。

Abstract

This study was conducted to evaluate the application value of a degradable liquid fiducial marker (LFM) in image-guided radiotherapy. ,In vitro, experiment: using a solid fiducial marker (SFM) as a reference, the visibility, artifact, and optimal injection volume of an LFM under different cone beam CT tube voltage conditions were evaluated. ,In vivo, experiment: using the SFM as a reference, the stability and degradation status of the LFM in nude mice were evaluated. Nude mice implanted with tumor cells were randomly divided into four groups: single fraction radiotherapy group (16 Gy/fraction) without LFM injection, single fraction radiotherapy group (16 Gy/fraction) with LFM injection, 2 fractions radiotherapy group (8 Gy/fraction) with LFM injection, and 4 fractions radiotherapy group (4 Gy/fraction) with LFM injection. The impact of LFM on tumor growth was evaluated based on the irradiation results. Compared with SFM, the LFM artifacts were significantly smaller (all ,p,<,0.05), and the visibility met the clinical differentiation requirements. The best imaging quality was achieved when the injection volume was 10 μL. The displacement of the LFM centroid relative to the spinal cord in the nude mice was significantly greater than that of the gold fiducial marker ((0.22 ± 0.03) mm ,vs., (0.17 ± 0.02) mm,p,<,0.05); however, it was always smaller than a pixel size. The results indicated good stability. The actual degradation rate of the LFM was highly consistent with the theoretical degradation rate. The LFM had a relatively smaller impact on tumor growth in the single fraction radiotherapy group but a greater impact in the fractional radiotherapy groups. LFMs have certain clinical applications and promotional value, and they are expected to replace SFMs in the future.

关键词

液态基准标志物图像引导放疗应用价值

Keywords

Liquid fiducial markerImage guided radiotherapyApplication value

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