纳米粒子型硼携带剂用于硼中子俘获治疗的研究进展

史豪杰; 李凤林; 樊彩云; 徐千龙

doi:10.11889/j.1000-3436.2025-0102

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纳米粒子型硼携带剂用于硼中子俘获治疗的研究进展

更新时间：2026-05-06

- 纳米粒子型硼携带剂用于硼中子俘获治疗的研究进展
- Progress in nanotechnology-based boron agents for BNCT
- 辐射研究与辐射工艺学报 2026年页码：1-14
- 作者机构：
  
  中国原子能科学研究院北京 102413
- 作者简介：
  
  史豪杰，男，2001年3月出生，2023年6月于东北林业大学获学士学位，现为中国原子能科学研究院在读硕士研究生，分析化学、放射性药物研究， E-mail： 863593574@qq.com
  李凤林，研究员，硕士研究生导师，E-mail： 99789770@qq.com
- 基金信息：
  
  中国原子能科学研究院产业基金项目(PG040270925876)
- DOI：10.11889/j.1000-3436.2025-0102
  中图分类号： R9
- 收稿：2025-10-24，
  
  修回：2026-01-09，
  
  录用：2026-01-09，
  
  网络首发：2026-05-06，
- 稿件说明：
移动端阅览
引用该文：史豪杰, 李凤林, 樊彩云, 等. 纳米粒子型硼携带剂用于硼中子俘获治疗的研究进展[J]. 辐射研究与辐射工艺学报, XXXX, XX(XX): XXXXXX.

SHI Haojie, LI Fenglin, FAN Caiyun, et al. Progress in nanotechnology-based boron agents for BNCT[J]. Journal of Radiation Research and Radiation Processing, XXXX, XX(XX): XXXXXX.
引用该文：史豪杰, 李凤林, 樊彩云, 等. 纳米粒子型硼携带剂用于硼中子俘获治疗的研究进展[J]. 辐射研究与辐射工艺学报, XXXX, XX(XX): XXXXXX. DOI： 10.11889/j.1000-3436.2025-0102. CSTR： 32195.14.j.JRRRP.1000-3436.2025-0102.

SHI Haojie, LI Fenglin, FAN Caiyun, et al. Progress in nanotechnology-based boron agents for BNCT[J]. Journal of Radiation Research and Radiation Processing, XXXX, XX(XX): XXXXXX. DOI： 10.11889/j.1000-3436.2025-0102. CSTR： 32195.14.j.JRRRP.1000-3436.2025-0102.

摘要

硼中子俘获治疗（Boron neutron capture therapy，BNCT）是一种基于二元靶向的肿瘤治疗方式，含硼药物在肿瘤特异性富集后，经热中子局部照射，通过

B（n，α）⁷Li核反应从而实现肿瘤的精准放疗。第二代硼携带剂硼苯丙氨酸（Boronophenylalanine，BPA）、巯基十二硼烷二钠盐（Sodium borocaptate，BSH）在肿瘤治疗中展现出良好的治疗效果，但也存在肿瘤靶向性不足、体内代谢快或溶解性差等问题，为应对以上挑战，基于纳米技术的纳米粒子型硼携带剂已成为能否增强BNCT治疗效果的关键之一。本文系统回顾了纳米粒子型硼携带剂的研究进展，同时对于目前纳米粒子型硼携带剂存在的不足进行分析并提出建议，以期为纳米粒子型硼携带剂在基础和临床研究应用中的发展提供一定帮助。

Abstract

Boron neutron capture therapy (BNCT) is a two-step targeted radiotherapy technique. It involves the selective delivery of boron agents to tumor tissues

followed by thermal neutron irradiation. The subsequent

B(n

α)⁷Li nuclear reaction results in selective destruction of tumor

cells. The second-generation boron agents

boronophenylalanine (BPA) and sodium borocaptate (BSH)

have demonstrated promising results in tumor treatment. However

they still face several challenges

such as insufficient tumor targeting

rapid metabolism or poor solubility. In order to meet the above challenges

nanotechnology-based boron agents have become a key strategy to enhance the therapeutic effect of BNCT. In this article

we systematically review the research progress of nanotechnology-based boron agents

and at the same time

critically analyze the shortcomings of current nanocarriers and propose potential solutions

with the aim of facilitating the translation of nanotechnology-based boron agents into both basic research and clinical applications.

关键词

Keywords

references

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