
1.中国辐射防护研究院 太原 030006
郭月凤,女,1962年12出生,1983年毕业于北京大学生物系,生理专业,现任中国辐射防护研究院副研究员,从事辐射生物效应及放射医学研究
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郭月凤, 王明明. 不同孕期雌性大鼠受137Cs γ射线照射后仔鼠脑发育的变化[J]. 辐射研究与辐射工艺学报, 2004,22(4):234-236.
GUO Yuefeng, WANG Mingming. changes in brain development of rat fetus exposed to 137Cs γ rays in different pregnant periods of the female rats[J]. Journal of Radiation Research and Radiation Processing, 2004,22(4):234-236.
郭月凤, 王明明. 不同孕期雌性大鼠受137Cs γ射线照射后仔鼠脑发育的变化[J]. 辐射研究与辐射工艺学报, 2004,22(4):234-236. DOI:
GUO Yuefeng, WANG Mingming. changes in brain development of rat fetus exposed to 137Cs γ rays in different pregnant periods of the female rats[J]. Journal of Radiation Research and Radiation Processing, 2004,22(4):234-236. DOI:
用,137,Cs γ射线对孕期分别为第11天和第16天的雌性大鼠进行一次性全身照射,吸收剂量分别为0.2、0.4、0.9、2.0Gy,观察胚胎发育不同时期受,137,Cs γ射线照射后仔鼠条件饮水反应和大脑海马锥体细胞计数的变化。结果表明,不同孕期的孕鼠受,137,Cs γ射线照射均可导致仔鼠大脑海马锥体细胞计数和条件饮水反应达标率显著减少,两者的剂量效应关系均可表示为,Y,=a−blog,10,D,(,Y,为效应,,D,为剂量);仔鼠的条件饮水反应达标率与其大脑锥体细胞计数显著相关,且孕期第11天受照射仔鼠的条件饮水反应达标率低于孕期第16天受照射的仔鼠。
Pregnant rats in 11d and 16d of their pregnancy were given one−off whole body exposure by ,137,Cs γ rays to 0.2, 0.4, 0.9 and 2.0Gy, respectively. Changes were observed in conditioned drinking response and cerebrum hippocampi cone cell number of the baby rats exposed to the γ rays in different periods of their embryo development. As a result, that pregnant rats exposed to ,137,Cs γ rays in different pregnant periods may induce significant decrease in cerebrum hippocampi cone cell number and achieving rate of conditioned drinking response of the babies. The dose−response relationship can be described by ,Y, = a−b log,10,D,. The achieving rate of conditioned drinking response were significantly correlated to cerebrum hippocampi cone cell number in the babies, and the achieving rate of conditioned drinking response of the babies exposed at pregnant 11d was lower than others exposed at pregnant 16d.
孕期脑发育剂量效应关系
Pregnant periodsBrain developmentDose−response relationship
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