YU Long, AN Xiao. Screening on the high yield validamycin producing strain by implantationwith N+ and Ti+ ion sources[J]. Journal of Radiation Research and Radiation Processing, 2007,25(6):371-374.
YU Long, AN Xiao. Screening on the high yield validamycin producing strain by implantationwith N+ and Ti+ ion sources[J]. Journal of Radiation Research and Radiation Processing, 2007,25(6):371-374.DOI:
In order to compared the mutagenic effects of the validamycin producing the strain (,Streptomyces hygroscupicus, var. ,Jingganggensis, Yen.) was implanted with two kinds of ion sources. The results showed that when two kinds of ion sources implanted into the strain by turns, more positive mutants and higher yield would be acquired. Using this method, a high-yielding strain B1-3 was obtained, which produce the titer of validamycin A of 21514, and was 54.4% higher than that of the original strain.