局部照射和全身照射诱发小鼠精原细胞染色体畸变的比较

王献理; 王彬; 孙淑清

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局部照射和全身照射诱发小鼠精原细胞染色体畸变的比较

更新时间：2023-04-23

- 局部照射和全身照射诱发小鼠精原细胞染色体畸变的比较
- COMPRISON OF LOCAL TESTIS IRRADIATION-WITH WHOLE BODY IRRADIATION-INDUCED TRANSLOCATION IN SPERMATOGONIA OF MICE
- 辐射研究与辐射工艺学报 1990年8卷第3期页码：141-144
- 作者机构：
  
  1.白求恩医科大学放射医学研究所，长春
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王献理, 王彬, 孙淑清. 局部照射和全身照射诱发小鼠精原细胞染色体畸变的比较[J]. 辐射研究与辐射工艺学报, 1990,8(3):141-144.

Wang Xianli, Wang Bin, Sun Shuqing. COMPRISON OF LOCAL TESTIS IRRADIATION-WITH WHOLE BODY IRRADIATION-INDUCED TRANSLOCATION IN SPERMATOGONIA OF MICE[J]. Journal of Radiation Research and Radiation Processing, 1990,8(3):141-144.
王献理, 王彬, 孙淑清. 局部照射和全身照射诱发小鼠精原细胞染色体畸变的比较[J]. 辐射研究与辐射工艺学报, 1990,8(3):141-144. DOI：

Wang Xianli, Wang Bin, Sun Shuqing. COMPRISON OF LOCAL TESTIS IRRADIATION-WITH WHOLE BODY IRRADIATION-INDUCED TRANSLOCATION IN SPERMATOGONIA OF MICE[J]. Journal of Radiation Research and Radiation Processing, 1990,8(3):141-144. DOI：

摘要

本文对X线照射小鼠睾丸组织和全身均匀照射诱发精原细胞染色体易位率进行了比较。两种不同照射方式所诱发的易位率都随剂量增加而增高，其剂量效应关系均符合y=a+bD关系式。全身照射明显高于局部受照，从而提示用全身均匀照射的遗传风险来估价睾丸组织受照的遗传效应是不适宜的，它过高的估价了遗传危险度。因此对常见的生殖器官局部受照的遗传危害，应该用局部照射的资料来评估，更接近实际。

Abstract

It was compared for the translocation rate in spermatogonia of mice irradiated in local testis with that irradiated in whole body. The rate in irradiated groups increased linearly with doses. The coefficient of two equations for dose-effect is significant difference, it is higher in whole-body irradiated group than that in local testis irradiated group. The estimate for genetic risk resulted from the whole -body irradiated experiments is not suitable, if so, it will be higher. Andso the evaluating the genetic risk for reproduction system irradiated should be basic on the data of local radiation in the testis.

关键词

精原细胞遗传危险生殖细胞染色体畸变

Keywords

SpermatogoniaGenetic riskGerm cells Chromosome aberration

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¹²⁵I诱发小鼠生殖细胞染色体畸变效应观察