用气相色谱法对一次性输液器中残留环氧乙烷辐解效应的研究

王明锁; 滕维芳; 刘克良; 冯纪辛; 苏燎原; 徐利英; 尤桂兴

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用气相色谱法对一次性输液器中残留环氧乙烷辐解效应的研究

更新时间：2023-04-23

- 用气相色谱法对一次性输液器中残留环氧乙烷辐解效应的研究
- STUDY OF RADIOLYTIC EFFECT ON RESIDUAL ETHYLENE OXIDE IN PERFUSION DEVICES FOR SINGLE USE USING GAS CHROMATOGRAPHY
- 辐射研究与辐射工艺学报 1993年11卷第1期页码：31-35
- 作者机构：
  
  1.苏州医学院，苏州　215007
  2.苏州大学，苏州　215006
  3.常熟市康福高分子医疗器械厂，江苏常熟　215006
- 作者简介：
- 基金信息：
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王明锁, 滕维芳, 刘克良, 等. 用气相色谱法对一次性输液器中残留环氧乙烷辐解效应的研究[J]. 辐射研究与辐射工艺学报, 1993,11(1):31-35.

Wang Mingsuo, Teng Weifang, Liu Keliang, et al. STUDY OF RADIOLYTIC EFFECT ON RESIDUAL ETHYLENE OXIDE IN PERFUSION DEVICES FOR SINGLE USE USING GAS CHROMATOGRAPHY[J]. Journal of Radiation Research and Radiation Processing, 1993,11(1):31-35.
王明锁, 滕维芳, 刘克良, 等. 用气相色谱法对一次性输液器中残留环氧乙烷辐解效应的研究[J]. 辐射研究与辐射工艺学报, 1993,11(1):31-35. DOI：

Wang Mingsuo, Teng Weifang, Liu Keliang, et al. STUDY OF RADIOLYTIC EFFECT ON RESIDUAL ETHYLENE OXIDE IN PERFUSION DEVICES FOR SINGLE USE USING GAS CHROMATOGRAPHY[J]. Journal of Radiation Research and Radiation Processing, 1993,11(1):31-35. DOI：

摘要

应用气相色谱法研究了一次性使用输液器中残留环氧乙烷（RETO）经,60,Co γ射线辐照所致的消去反应的效果。实验结果表明：（1）经环氧乙烷灭菌后的医疗用品所吸附的RETO在4 kGy辐照下发生辐解，其相对清除率（RELP）超过90%。（2）辐解效应的最佳条件为：剂量4 kGy，剂量率8 Gy/min，辐照温度20℃。（3）经辐照贮放2周后的医疗用品，其RETO含量可控制在2.0 ppm以下。

Abstract

The efficiency of the ,60,Co γ-rays irradiation induced elimination reaction of residual ethylene oxide (RETO) in the perfusion devices for single use conducted with RETO gas chromatography has been studied. The observations show: 1. the spliting reaction of RETO absorbed by the infusion sets after ethylene oxide(ETO) sterilization occured accompanied with 4kGy irradiation, therefore the relative elimination percentage (RELP) calculatted from RETO is over 90%. 2. the optimum radiation conditions are as following: irradiation dose 4 kGy, dose rate 8 Gy/min, irradiation temprature 20℃. 3. the RETO content within medical infusion sets at 2 weeks storing time after radiation was probably controlled under 2.0 ppm. 4. the radiation chemistry mechanism of the RETO elimination reaction is discussed in relation to the primary and secondary actions of elimination reaction.

关键词

气相色谱法输液器环氧乙烷辐解效应化学灭菌

Keywords

Gas chromatographyPerfusion devicesEthylene oxideRadiolytic effectChemical sterilization

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