辐射对小鼠组织中脂质过氧化物和蛋白质的影响及单宁酸与鲨烯的抗脂质过氧化作用

王崇道; 劳勤华; 强亦忠; 沈维明

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辐射对小鼠组织中脂质过氧化物和蛋白质的影响及单宁酸与鲨烯的抗脂质过氧化作用

更新时间：2023-04-23

- 辐射对小鼠组织中脂质过氧化物和蛋白质的影响及单宁酸与鲨烯的抗脂质过氧化作用
- EFFECTS OF RADIATION ON LIPID PEROXIDES AND PROTEINS IN RATS AND ANTI-LPO EFFECTS OF TANNIC ACID AND SQUALENE
- 辐射研究与辐射工艺学报 1993年11卷第1期页码：49-52
- 作者机构：
  
  1.苏州医学院，苏州　215007
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王崇道, 劳勤华, 强亦忠, 等. 辐射对小鼠组织中脂质过氧化物和蛋白质的影响及单宁酸与鲨烯的抗脂质过氧化作用[J]. 辐射研究与辐射工艺学报, 1993,11(1):49-52.

Wang Chongdao, Lao Qinhua, Qiang Yizhong, et al. EFFECTS OF RADIATION ON LIPID PEROXIDES AND PROTEINS IN RATS AND ANTI-LPO EFFECTS OF TANNIC ACID AND SQUALENE[J]. Journal of Radiation Research and Radiation Processing, 1993,11(1):49-52.
王崇道, 劳勤华, 强亦忠, 等. 辐射对小鼠组织中脂质过氧化物和蛋白质的影响及单宁酸与鲨烯的抗脂质过氧化作用[J]. 辐射研究与辐射工艺学报, 1993,11(1):49-52. DOI：

Wang Chongdao, Lao Qinhua, Qiang Yizhong, et al. EFFECTS OF RADIATION ON LIPID PEROXIDES AND PROTEINS IN RATS AND ANTI-LPO EFFECTS OF TANNIC ACID AND SQUALENE[J]. Journal of Radiation Research and Radiation Processing, 1993,11(1):49-52. DOI：

摘要

采用改良的TBA比色法测定组织中的脂质过氧化物（LPO）。结果表明：（1）Th（NO,3,）,4,内照射后第15d时，小鼠肝、脾、肾和骨髓中的LPO含量明显升高，而组织中的蛋白质却明显降低，两者呈负相关；（2）γ线整体照射（2—4 Gy）后72 h，小鼠肝、脾和肾中的LPO含量随着剂量的增加而升高。辐射剂量与LPO含量之间呈现显著线性关系；（3）单宁酸与鲨烯有抗脂质过氧化作用。

Abstract

Lipid peroxides (LPO) in the tissues of mice was determenined by the modified spectrophotometry with TBA. The results showed: 1) LPO contents in liver, spleen, kidney and bone marrow of mice dramatically increased and their proteins markedly reduced at the 15 th day after internal radiation. There exists negative relationship between them. 2) A gradual increase of LPO contents in liver, spleen and kidney of mice at the 72 th hour was followed by an increase of whole-body gamma radiation at a dose from 2 to 4 Gy. A linear relationship between the dose and LPO contents was observed in the dose range of 0—4 Gy. 3) Tannic acid and squalene had certain anti-LPO effects.

关键词

γ辐射脂质过氧化物小鼠单宁酸鲨烯比色法

Keywords

γ-RadiationLipid peroxidesMouseTannic acidSqualeneSpectrophotometry

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