<sup>60</sup>Co-γ线低剂量率照射狗染色体畸变的观察

朱炳钗; 张鸿源; 陈改臣; 韩国馨; 何南章; 贾福星; 王宗伍; 吕家本; 王兰金

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⁶⁰Co-γ线低剂量率照射狗染色体畸变的观察

研究论文及科研成果报告 | 更新时间：2023-04-26

- ⁶⁰Co-γ线低剂量率照射狗染色体畸变的观察
- STUDIES ON CHROMOSOME ABERRATIONS IN DOGS IRRADIATED WITH LOW DOSE RATE OF ⁶⁰Co γ-RAYS
- 辐射研究与辐射工艺学报 1986年4卷第2期页码：37-41
- 作者机构：
  
  1.海军医学研究所
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朱炳钗, 张鸿源, 陈改臣, 等. ⁶⁰Co-γ线低剂量率照射狗染色体畸变的观察[J]. 辐射研究与辐射工艺学报, 1986,4(2):37-41.

Zhu Bing chai, Zhang Hongyuan, Chen Gaichen, et al. STUDIES ON CHROMOSOME ABERRATIONS IN DOGS IRRADIATED WITH LOW DOSE RATE OF ⁶⁰Co γ-RAYS[J]. Journal of Radiation Research and Radiation Processing, 1986,4(2):37-41.
朱炳钗, 张鸿源, 陈改臣, 等. ⁶⁰Co-γ线低剂量率照射狗染色体畸变的观察[J]. 辐射研究与辐射工艺学报, 1986,4(2):37-41. DOI：

Zhu Bing chai, Zhang Hongyuan, Chen Gaichen, et al. STUDIES ON CHROMOSOME ABERRATIONS IN DOGS IRRADIATED WITH LOW DOSE RATE OF ⁶⁰Co γ-RAYS[J]. Journal of Radiation Research and Radiation Processing, 1986,4(2):37-41. DOI：

摘要

本研究用0.427 rad/d和0.178 rad/d两种剂量率,60,Co-γ线连续照射狗三年，其累积剂量分别为315.2 rad和131.4 rad。在照射期间及停照后三年内对实验狗的外周血淋巴细胞染色体畸变进行了观察。结果表明，染色体畸变主要为一次击中畸变，其中无着丝点断片畸变率与累积剂量呈线性相关，在一定剂量范围内，可考虑作为慢性辐射损伤的灵敏指标。停照后三个月时，无着丝点断片畸变率已接近对照组水平。自停照后六个月开始，照射组动物的畸变率都在自发畸变率范围变动。本实验揭示建立低剂量率长期照射的剂量-效应曲线的可能性值得进一步探讨。

Abstract

Dogs were continualy exposed to ,60,Co r-rays at dose rates of 0.427 and 0.178 rad/day respectively for 3 years. The accumulated doses were 315.2 rad and 131.4 rad respectively. During the period of radiation and 3 years after, chromosome aberrations in peripheral blood lymphocytes have been observed. The results showed that the chromosome aberrations were mainly one hit-aberration, and the acentric fragmentt increased linearly with accumulated dose. According to the results, the acentric fragments can be used as a sensitive index for chronic radiation injury. Following three and six months after exposure the frequencies of acentric fragment decreased near to and within the control level respectively.

关键词

低剂量率染色体畸变无着丝点断片剂量-效应曲线

Keywords

Low dose rateChromosome aberrationAcentric fragmentDose-response curve

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摘要

Abstract

关键词

Keywords

references

⁶⁰Co-γ线低剂量率照射狗染色体畸变的观察

STUDIES ON CHROMOSOME ABERRATIONS IN DOGS IRRADIATED WITH LOW DOSE RATE OF ⁶⁰Co γ-RAYS