<sup>60</sup>Co γ射线诱发小鼠卵母细胞和骨髓细胞染色体畸变的量效关系比较

杨莉玲; 高锦声; 郑斯英

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⁶⁰Co γ射线诱发小鼠卵母细胞和骨髓细胞染色体畸变的量效关系比较

研究论文 | 更新时间：2023-05-04

- ⁶⁰Co γ射线诱发小鼠卵母细胞和骨髓细胞染色体畸变的量效关系比较
- DOSE-RESPONSE RELATIONSHIP AND ITS COMPARISONS OF ⁶⁰Co γ-RAY INDUCED CHROMOSOME ABERRATIONS IN M Ⅱ OOCYTES AND BONE MARROW CELLS OF MICE
- 辐射研究与辐射工艺学报 1995年13卷第2期页码：109-113
- 作者机构：
  
  1.苏州医学院辐射与医学遗传室，苏州　215007
- 作者简介：
- 基金信息：
  
  核工业部自然科学基金课题
- DOI：
  中图分类号：
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杨莉玲, 高锦声, 郑斯英. ⁶⁰Co γ射线诱发小鼠卵母细胞和骨髓细胞染色体畸变的量效关系比较[J]. 辐射研究与辐射工艺学报, 1995,13(2):109-113.

Yang Liling, Gao Jinsheng, Zheng Siying. DOSE-RESPONSE RELATIONSHIP AND ITS COMPARISONS OF ⁶⁰Co γ-RAY INDUCED CHROMOSOME ABERRATIONS IN M Ⅱ OOCYTES AND BONE MARROW CELLS OF MICE[J]. Journal of Radiation Research and Radiation Processing, 1995,13(2):109-113.
杨莉玲, 高锦声, 郑斯英. ⁶⁰Co γ射线诱发小鼠卵母细胞和骨髓细胞染色体畸变的量效关系比较[J]. 辐射研究与辐射工艺学报, 1995,13(2):109-113. DOI：

Yang Liling, Gao Jinsheng, Zheng Siying. DOSE-RESPONSE RELATIONSHIP AND ITS COMPARISONS OF ⁶⁰Co γ-RAY INDUCED CHROMOSOME ABERRATIONS IN M Ⅱ OOCYTES AND BONE MARROW CELLS OF MICE[J]. Journal of Radiation Research and Radiation Processing, 1995,13(2):109-113. DOI：

摘要

用不同剂量（0～3 Gy）,60,Co γ射线一次全身性照射雌性ICR小鼠，观察MⅡ（第二次减数分裂中期）卵母细胞和骨髓细胞染色体损伤效应，用WHO推荐的4个模式进行剂量效应曲线的拟合，选出最优的拟合模式，并对MⅡ卵母细胞和骨髓细胞的量效关系式进行了比较。结果表明，MⅡ卵母细胞和骨髓细胞均为辐射的敏感指标。骨髓细胞的辐射敏感性高于MⅡ卵母细胞。

Abstract

Chromosome aberrations induced by various ,60,Co γ-ray doses(0~3 Gy) were examined in secondary oocytes and bone marrow cells of ICR mice. The chromosome aberration rates of the two cell lines were both significantly higher in γ-irradiated groups than that in control ones. Using four models recommended by WHO, dose-response calibration curves were established and better matches were selected: they were ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=43004025&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=43004028&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=43004026&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=43004040&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=43004042&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=43004030&type=, for aberrant cell and total chromosome aberration rates(%) of oocytes, respectively. And ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=43004032&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=43004047&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=43004033&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=43004049&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=43004051&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=43004035&type=, for aberrant cell and total chromosome aberration rates(%) of bone marrow cells, respectively. A comparison of radiosensitivity between MⅡ oocytes and bone marrow cells were also made, the results showed that both MⅡ oocytes and bone marrow cells were sensitive, the bone marrow cell radiosensitivity was higher than that of MⅡ oocytes by 2.2 times.

关键词

γ射线染色体畸变量效关系辐射敏感性

Keywords

60Co γ-rayChromosome aberrationDose-reaponse relationshipRadiosensitivity

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60Co γ射线诱发小鼠卵母细胞和骨髓细胞染色体畸变的量效关系比较

DOSE-RESPONSE RELATIONSHIP AND ITS COMPARISONS OF 60Co γ-RAY INDUCED CHROMOSOME ABERRATIONS IN M Ⅱ OOCYTES AND BONE MARROW CELLS OF MICE

DOI：

摘要

Abstract

关键词

Keywords

references

⁶⁰Co γ射线诱发小鼠卵母细胞和骨髓细胞染色体畸变的量效关系比较

DOSE-RESPONSE RELATIONSHIP AND ITS COMPARISONS OF ⁶⁰Co γ-RAY INDUCED CHROMOSOME ABERRATIONS IN M Ⅱ OOCYTES AND BONE MARROW CELLS OF MICE