小剂量低剂量率X射线诱发小鼠卵母细胞染色体畸变的研究

王献理; 孙淑清; 王彬; 王明东

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小剂量低剂量率X射线诱发小鼠卵母细胞染色体畸变的研究

更新时间：2024-11-05

- 小剂量低剂量率X射线诱发小鼠卵母细胞染色体畸变的研究
- PRELIMINARY STUDY ON CHROMOSOME DAMAGE INDUCED BY LOW DOSE X-RAYS IN SECONDARY OOCYTES OF MICE
- 辐射研究与辐射工艺学报 1991年9卷第2期页码：79-82
- 作者机构：
  
  白求恩医科大学放射医学研究所，长春
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 纸质出版日期：1991-05，
  
  收稿日期：1989-08-24，
- 稿件说明：
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王献理, 孙淑清, 王彬, 等. 小剂量低剂量率X射线诱发小鼠卵母细胞染色体畸变的研究[J]. 辐射研究与辐射工艺学报, 1991,9(2):79-82.

Wang Xianli, Sun Shuqing, Wang Bin, et al. PRELIMINARY STUDY ON CHROMOSOME DAMAGE INDUCED BY LOW DOSE X-RAYS IN SECONDARY OOCYTES OF MICE. [J]. Journal of Radiation Research and Radiation Processing, 1991,9(2):79-82.
王献理, 孙淑清, 王彬, 等. 小剂量低剂量率X射线诱发小鼠卵母细胞染色体畸变的研究[J]. 辐射研究与辐射工艺学报, 1991,9(2):79-82. DOI：

Wang Xianli, Sun Shuqing, Wang Bin, et al. PRELIMINARY STUDY ON CHROMOSOME DAMAGE INDUCED BY LOW DOSE X-RAYS IN SECONDARY OOCYTES OF MICE. [J]. Journal of Radiation Research and Radiation Processing, 1991,9(2):79-82. DOI：

摘要

采用超数排卵技术，在相对较低剂量（0.25、0.50、0.75和1.00 Gy）X线照射下，观察了全身照射雌性小鼠对次级卵母细胞染色体的损伤。各受照组染色体畸变率均明显高于对照组，并与剂量呈线性相关（Y

总

=0.0091+0.1230 D）。染色体着丝粒分离率同样都高于对照组，在0—0.75 Gy范围内，其发生率与剂量呈线性相关（Y=- 0.0002+0.0442 D）。并进一步估算，在0.75和1.0 Gy组预期其子代易位携带者的再现率为0.22%和0.36%。

Abstract

The chromosome damage caused by relative low doses (0.25

0.50

0.75 and 1.00 Gy) of X-rays was examined in secondary oocytes of mice. The frequency of chromosome aberrations was significantly higher in each X-irradiated group than that in control group with the tendency of increasing linearly with X-rays dose(Y=0.0091+0.1230 D)

The frequency of centromere splits was also markedly higher in each irradiated group than that in contro

l. In the dose range of 0-0.75 Gy

the dose-effect relationship was fitted well to linear equation

eg. Y=- 0.0002+ 0.0442 D. Using the frequency of chromatid aberrations in M

Ⅱ

the risk of balanced translocations in the offspring were predicted to be 0.22% and 0.36% in the 0.75 and 1.00 Gy groups respectively.

关键词

低剂量卵母细胞染色体畸变易位携带者超数排卵

Keywords

Low doseMouse oocyteChromosome aberrationCarrier of the translocation

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