电离辐射对人皮肤成纤维细胞中超氧阴离子自由基浓度和超氧化物歧化酶与组织蛋白酶D活力的影响

乐敏; 刘莉; 王荷英; 何介薇

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电离辐射对人皮肤成纤维细胞中超氧阴离子自由基浓度和超氧化物歧化酶与组织蛋白酶D活力的影响

简报 | 更新时间：2023-04-23

- 电离辐射对人皮肤成纤维细胞中超氧阴离子自由基浓度和超氧化物歧化酶与组织蛋白酶D活力的影响
- RADIATION EFFECTS ON THE CONCENTRATION OF SOD AND CATHEPSIN D ACTIVITIES IN CULTURED SKIN FIBROBLASTS
- 辐射研究与辐射工艺学报 1995年13卷第4期页码：243-245
- 作者机构：
  
  1.上海医科大学放射医学研究所，上海　200032
- 作者简介：
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乐敏, 刘莉, 王荷英, 等. 电离辐射对人皮肤成纤维细胞中超氧阴离子自由基浓度和超氧化物歧化酶与组织蛋白酶D活力的影响[J]. 辐射研究与辐射工艺学报, 1995,13(4):243-245.

Le Min, Liu Li, Wang Heying, et al. RADIATION EFFECTS ON THE CONCENTRATION OF SOD AND CATHEPSIN D ACTIVITIES IN CULTURED SKIN FIBROBLASTS[J]. Journal of Radiation Research and Radiation Processing, 1995,13(4):243-245.
乐敏, 刘莉, 王荷英, 等. 电离辐射对人皮肤成纤维细胞中超氧阴离子自由基浓度和超氧化物歧化酶与组织蛋白酶D活力的影响[J]. 辐射研究与辐射工艺学报, 1995,13(4):243-245. DOI：

Le Min, Liu Li, Wang Heying, et al. RADIATION EFFECTS ON THE CONCENTRATION OF SOD AND CATHEPSIN D ACTIVITIES IN CULTURED SKIN FIBROBLASTS[J]. Journal of Radiation Research and Radiation Processing, 1995,13(4):243-245. DOI：

摘要

60,Co γ射线10～40 Gy照射正常人皮肤成纤维细胞，1h后，细胞释放超氧阴离子自由基（,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650922&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650939&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650932&type=,）量显著增高，其增高与照射剂量呈正相关。细胞超氧化物歧化酶（SOD）活力明显下降，且与照射剂量呈负相关。组织蛋白酶D活力显著增高，其增高与照射剂量呈正相关。在辐照0～40 Gy范围内，细胞释放,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650934&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650942&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650935&type=,量与细胞SOD活力呈负相关，而细胞释放,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650943&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650945&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650944&type=,量与细胞组织蛋白酶D活力呈正相关。

Abstract

Human skin fibroblasts were irradiated with ,60,Co γ-ray 10 Gy~40 Gy. After one hour, the concentration of ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650946&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650948&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650947&type=, increased significantly, the activity of SOD in cultured fibroblasts decreased markedly, and the activity of cathepsin D increased significantly. These changes related with the dose, when the radiation dose with the range of 0~40 Gy, the concentration of ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650949&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650937&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42650936&type=, related with the activity of SOD and cathepsin D in cultured skin fibroblasts.

关键词

辐射效应细胞自由基SOD组织蛋白酶D

Keywords

Radiation effectCellFree radicalSODCathepsin D

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