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LIU Xiongxiong1; 2; 3; LI Qiang1; 2

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更新时间：2021-12-01

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- Journal of Radiation Research and Radiation Processing Vol. 31, Issue 6, Pages: 60101-060101(2013)
- 作者机构：
  
  1. 1（中国科学院近代物理研究所）,兰州,730000
  2. 2（中国科学院重离子辐射生物医学重点实验室）,兰州,730000
  3. 3（中国科学院大学）,北京,100049
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LIU Xiongxiong1, 2, 3, et al. [J]. Journal of Radiation Research and Radiation Processing 31(6):60101-060101(2013)
DOI：

LIU Xiongxiong1, 2, 3, et al. [J]. Journal of Radiation Research and Radiation Processing 31(6):60101-060101(2013) DOI：

摘要

氧化应激不但可导致基因遗传变化，还可诱发表观遗传变化。氧化应激引起的遗传变化主要是活性氧（ROS）攻击DNA，造成DNA链断裂、碱基修饰、DNA-DNA交联和DNA-蛋白质交联等多种形式的DNA损伤，这些损伤在肿瘤发生起始阶段发挥重要作用。氧化应激引起的表观遗传变化中，一个重要的机制是DNA 甲基化水平改变，主要表现在高甲基化引起基因转录抑制（如抑癌基因）和低甲基化诱导基因转录激活（如癌基因），DNA甲基化水平变化与肿瘤发生息息相关。本工作介绍了ROS诱导的氧化应激引起的遗传改变和DNA甲基化水平变化在肿瘤发生中的作用，并展望了肿瘤治疗的发展趋势。

Abstract

Oxidative stress can initiate genetic and epigenetic alterations. Oxidative stress-induced genetic changes mainly involve that ROS attacks DNA, inducing various DNA changes like strand breaks, base modi?cations, DNA-DNA and DNA-protein cross linkages which are all strongly implicated in the initiation stage of tumorigenesis. In oxidative stress-induced epigenetic changes, one of the most important mechanisms is the change of DNA methylation levels: hypermethylation-induced transcriptional repression (in the case of tumor suppressor genes) or hypomethylation-induced activation (in the case of oncogenes), which is closely associated with tumorigenesis. In this paper, the current status of knowledge on the role of ROS-induced oxidative stress in altering the genetic and DNA methylation during tumorigenesis was introduced, and the developing tendency of tumor therapy was prospected.Cited

关键词

肿瘤氧化应激遗传表观遗传DNA甲基化

Keywords

TumorOxidative stressGeneticEpigeneticDNA methylation

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