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LI Lei CHEN Qiu CUI Fengmei TU Yu

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更新时间：2021-12-01

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- Journal of Radiation Research and Radiation Processing Vol. 31, Issue 1, Pages: 1-010101(2013)
- 作者机构：
  
  1. （苏州大学医学部放射医学与防护学院）,苏州,215123
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LI Lei CHEN Qiu CUI Fengmei TU Yu. [J]. Journal of Radiation Research and Radiation Processing 31(1):1-010101(2013)
DOI：

LI Lei CHEN Qiu CUI Fengmei TU Yu. [J]. Journal of Radiation Research and Radiation Processing 31(1):1-010101(2013) DOI：

摘要

miR-34a位于染色体1p36.23区，作用于多种靶基因。miR-34a的异常表达可诱发细胞凋亡、周期阻滞和细胞分化，也可降低肿瘤细胞的转移，被认为是一种肿瘤抑制因子。抑癌基因p53可以激活miR-34a，miR-34a也可反馈调节p53表达。电离辐射诱导的miR-34a异常表达在DNA损伤修复、细胞凋亡、细胞周期调节和细胞辐射敏感性中发挥重要作用。本文综述电离辐射诱导miR-34a的产生及其参与的生物学反应和调控机制。

Abstract

miR-34a resides in the region of chromosome 1p36.23, which regulate a plethora of target genes. Ectopic miR-34a expression can induce apoptosis, cell cycle arrest and differentiation, meanwhile reduce migration of tumour cell which known as tumour inhibiting factor. p53 was shown a capability of activating miR-34a expression and miR-34a was also shown a feedback regulation to p53 gene in reverse. Ectopic expression of miR-34a induced by ionizing radiation plays an important role in DNA damage repair, apoptosis, cell cycle and cellular radiation sensitivity. This article reviews the progress in produce of miR-34a during ionizing radiation and its participation in biological response and relative mechanism in control.Cited

关键词

miR-34a电离辐射细胞凋亡细胞周期调节

Keywords

miR-34aIonizing radiationCell apoptosisCell cycle regulation

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